Results 51 to 60 of about 2,455,429 (307)
Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway
Molecular Oncology, EarlyView.Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed +10 more
wiley +1 more source
发电技术, 2021 The power and efficiency of thermoelectric generation are not only affected by the performance of thermoelectric generator and the temperature difference between the hot and cold ends, but also by other factors under certain conditions.
Yuanyuan SHI +6 more
doaj +1 more source
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Electronic Properties of DNA-Based Schottky Barrier Diodes in Response to Alpha Particles
Sensors, 2015 Detection of nuclear radiation such as alpha particles has become an important field of research in recent history due to nuclear threats and accidents.
Hassan Maktuff Jaber Al-Ta'ii +2 more
doaj +1 more source
Resistance of a compartmented surface-effect ship [PDF]
, 2010 A series of carefully controlled experiments on the resistance of a model of a compartmented surface-effect ship has been conducted in a towing tank. Configurations of the model included cases encompassing one subcushion and two subcushions, as well as ...
Beveridge, Philip +3 more
core
Molecular Oncology, EarlyView.We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto +8 more
wiley +1 more source
Kinetic-energy absorber employs frictional force between mating cylinders [PDF]
, 1964 A kinetic energy absorbing device uses a series of coaxial, mating cylindrical surfaces. These surfaces have high frictional resistance to relative motion when axial impact forces are applied.
Conrad, E. W.
core +1 more source
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Position-Dependent Performance in 5 nm Vertically Stacked Lateral Si Nanowires Transistors [PDF]
, 2017 In this work, we investigated the performance of vertically stacked lateral nanowires transistors (NWTs) considering the effects of series resistance. Also, we consider the vertical positions of the lateral nanowires in the stack and diameter variation ...
Adamu-Lema, F. +3 more
core
RF Transport Electromagnetic Properties of CVD Graphene from DC to 110 MHz [PDF]
, 2015 We report measurement of the radio-frequency (RF) transport electromagnetic properties of chemical vapour deposition (CVD) graphene over the DC to 110 MHz frequency range at room temperature.
Awan, Shakil Ahmed +4 more
core +3 more sources