Results 91 to 100 of about 701 (107)

Antiviral factors and their counteraction by HIV-1: many uncovered and more to be discovered. [PDF]

J Mol Cell Biol
Kmiec D, Kirchhoff F.
europepmc   +1 more source

Identification of novel biomarkers for hypertension and ventricular remodeling based on transcriptomics and machine learning. [PDF]

iScience
Li Z, Zhang B, Chao L, Tian X, Chen W, Liu C, Tian H.   +6 more
europepmc   +1 more source

Host Cell Virus Interactions: Molecular Mechanisms, Immune Modulation, Viral Pathogenesis, and Emerging Therapeutic Targets. [PDF]

Viruses
Alanazi A, Ibrahim MN, El Azab EF, Elithy MA.   +3 more
europepmc   +1 more source

Impact of natural HIV-1 Nef alleles and polymorphisms on SERINC3/5 downregulation [PDF]

, 2019
Jin, Steven
core  

Reduced SARS-CoV-2 infection levels and pathotype specific altered antiviral transcriptional response in IBD intestinal organoids

Jelusic B, Boerno S, Schimmel P, Wurm P, Przysiecki N, Watschinger C, Wolfgruber S, Hardt M, Anthofer M, Ehmann S, Klages S, Zatloukal K, Timmermann B, Moschen A, Gorkiewicz G.   +14 more
europepmc   +1 more source

SERINC3 and SERINC5 restrict HIV-1 infectivity and are counteracted by Nef

Nature, 2015
HIV-1 Nef and the unrelated mouse leukaemia virus glycosylated Gag (glycoGag) strongly enhance the infectivity of HIV-1 virions produced in certain cell types in a clathrin-dependent manner. Here we show that Nef and glycoGag prevent the incorporation of
Yoshiko Usami, Heinrich Göttlinger
exaly   +3 more sources

The antiviral activity of rodent and lagomorph SERINC3 and SERINC5 is counteracted by known viral antagonists

Journal of General Virology, 2019
A first step towards the development of a human immunodeficiency virus (HIV) animal model has been the identification and surmounting of species-specific barriers encountered by HIV along its replication cycle in cells from small animals.
Oliver T Keppler, Veit Hornung, Pedro Esteves   +2 more
exaly   +2 more sources

The Evolutionary Histories of Antiretroviral Proteins SERINC3 and SERINC5 Do Not Support an Evolutionary Arms Race in Primates [PDF]

Journal of Virology, 2016
Molecular evolutionary arms races between viruses and their hosts are important drivers of adaptation. These Red Queen dynamics have been frequently observed in primate retroviruses and their antagonists, host restriction factor genes, such as APOBEC3F/G,
Ben Murrell, Thomas Vollbrecht, Joel Wertheim   +2 more
exaly   +2 more sources

SERINC5 Potently Restricts Retrovirus Infection In Vivo

MBio, 2020
This study examined for the first time the in vivo function of the serine incorporator (SERINC) proteins during retrovirus infection. SERINC3 and SERINC5 (SERINC3/5) restrict a number of retroviruses, including human immunodeficiency virus 1 (HIV-1) and ...
Supawadee Umthong, Spyridon Stavrou, Uddhav Timilsina   +2 more
exaly   +2 more sources

Phosphoserine acidic cluster motifs bind distinct basic regions on the μ subunits of clathrin adaptor protein complexes [PDF]

Journal of Biological Chemistry, 2018
Protein trafficking in the endosomal system involves the recognition of specific signals within the cytoplasmic domains (CDs) of transmembrane proteins by clathrin adaptors.
Richard Wyatt, Yong Xiong, Xiaofei Jia   +2 more
exaly   +2 more sources