Results 1 to 10 of about 753,315 (199)

An atlas of substrate specificities for the human serine/threonine kinome

Nature, 2023
Protein phosphorylation is one of the most widespread post-translational modifications in biology^ 1 , 2 . With advances in mass-spectrometry-based phosphoproteomics, 90,000 sites of serine and threonine phosphorylation have so far been identified, and ...
Jared L. Johnson, Tomer M. Yaron, Emily M Huntsman, A. Kerelsky, Junho Song, Amit Regev, Ting Lin, Katarina M Liberatore, Daniel M. Cizin, Benjamin M. Cohen, N. Vasan, Yilun Ma, Konstantin Krismer, Jaylissa Torres Robles, Bert van de Kooij, Anne E. van Vlimmeren, Nicole Andrée-Busch, N. Käufer, M. Dorovkov, A. Ryazanov, Y. Takagi, Edward R. Kastenhuber, M. Goncalves, B. Hopkins, O. Elemento, D. Taatjes, A. Maucuer, A. Yamashita, A. Degterev, Mohamed Uduman, Jingyi Lu, Sean D. Landry, Bin Zhang, Ian Cossentino, R. Linding, J. Blenis, P. Hornbeck, B. Turk, M. Yaffe, L. Cantley   +39 more
semanticscholar   +1 more source

Insulin-regulated serine and lipid metabolism drive peripheral neuropathy

Nature, 2023
Serine deficiency can increase small fibre neuropathy in wild-type mice and serine replacement in diabetic mice alleviates diabetic neuropathy, directly linking amino acid metabolism to peripheral nerve disorders.
Michal K. Handzlik, Jivani M. Gengatharan, Katie Frizzi, G. McGregor, C. Martino, Gibraan Rahman, Antonio González, Ana M. Moreno, Courtney R. Green, L. Guernsey, Terry Lin, Patrick Tseng, Yoichiro Ideguchi, Regis Fallon, A. Chaix, Satchidananda Panda, P. Mali, M. Wallace, R. Knight, M. Gantner, N. Calcutt, Christian M. Metallo   +21 more
semanticscholar   +1 more source

Serine Metabolism in Health and Disease and as a Conditionally Essential Amino Acid

Nutrients, 2022
L-serine plays an essential role in a broad range of cellular functions including protein synthesis, neurotransmission, and folate and methionine cycles and synthesis of sphingolipids, phospholipids, and sulphur containing amino acids.
M. Holeček
semanticscholar   +1 more source

Phosphatidylethanolamine homeostasis under conditions of impaired CDP-ethanolamine pathway or phosphatidylserine decarboxylation

Frontiers in Nutrition, 2023
Phosphatidylethanolamine is the major inner-membrane lipid in the plasma and mitochondrial membranes. It is synthesized in the endoplasmic reticulum from ethanolamine and diacylglycerol (DAG) by the CDP-ethanolamine pathway and from phosphatidylserine by
Michaela St Germain, Roya Iraji, Marica Bakovic   +2 more
doaj   +1 more source

Effects of D-Serine and MK-801 on Neuropathic Pain and Functional Recovery in a Rat Model of Spinal Cord Injury [PDF]

Neurospine, 2022
Objective Neuropathic pain is a common secondary complication of spinal cord injury (SCI). N-methyl-D-aspartate (NMDA) receptor activation is critical for hypersensitivity in neuropathic pain.
Dongwoo Yu, Seul Ah Mun, Sang Woo Kim, Dae-Chul Cho, Chi Heon Kim, Inbo Han, Subum Lee, Sang-Woo Lee, Kyoung-Tae Kim   +8 more
doaj   +1 more source

Serine synthesis pathway inhibition cooperates with dietary serine and glycine limitation for cancer therapy

Nature Communications, 2021
Many tumour cells show dependence on exogenous serine and dietary serine and glycine starvation can inhibit the growth of these cancers and extend survival in mice.
Mylène Tajan, Marc Hennequart, E. Cheung, F. Zani, A. Hock, Nathalie M. Legrave, O. Maddocks, R. Ridgway, D. Athineos, A. Suárez‐Bonnet, R. Ludwig, Laura Novellasdemunt, Nikolaos Angelis, Vivian S. W. Li, G. Vlachogiannis, N. Valeri, N. Mainolfi, Vipin Suri, Adam J. Friedman, M. Manfredi, K. Blyth, O. Sansom, K. Vousden   +22 more
semanticscholar   +1 more source

#BlackCharactersMatter: If I’m Trying to Teach for Social Justice, Why Do All the Black Men and Boys on my Syllabus Die?

Radical Teacher, 2020
In this essay combining first-person narrative and scholarly literature, a classroom teacher examines the ways in which, despite having a self-professed goal of teaching for social justice, her syllabus centers, upholds, and normalize default whiteness ...
Andrea Serine Avery
doaj   +1 more source

Erwinia asparaginase (crisantaspase) increases plasma levels of serine and glycine

Frontiers in Oncology, 2022
The impact of asparaginases on plasma asparagine and glutamine is well established. However, the effect of asparaginases, particularly those derived from Erwinia chrysanthemi (also called crisantaspase), on circulating levels of other amino acids is ...
Dominique Bollino, Dominique Bollino, J. Preston Claiborne, J. Preston Claiborne, Kanwal Hameed, Xinrong Ma, Kayla M. Tighe, Brandon Carter-Cooper, Rena G. Lapidus, Rena G. Lapidus, Erin T. Strovel, Ashkan Emadi, Ashkan Emadi, Ashkan Emadi   +13 more
doaj   +1 more source

SHMT2 regulates serine metabolism to promote the progression and immunosuppression of papillary renal cell carcinoma

Frontiers in Oncology, 2022
Recent research has demonstrated the diverse relationship between tumour metabolism and the tumour microenvironment (TME), for example, abnormal serine metabolism.
Weiyu Kong, Weiyu Kong, Zhongyuan Wang, Nuoran Chen, Yiwen Mei, Yang Li, Yulin Yue   +6 more
doaj   +1 more source

The effect of a methyl group on structure and function: Serine vs. threonine glycosylation and phosphorylation

Frontiers in Molecular Biosciences, 2023
A variety of glycan structures cover the surface of all cells and are involved in myriad biological processes, including but not limited to, cell adhesion and communication, protein quality control, signal transduction and metabolism, while also being ...
Joseph J. Barchi, Caitlin N. Strain
doaj   +1 more source