Results 1 to 10 of about 644,358 (168)

Serine and glycine metabolism-related gene expression signature stratifies immune profiles of brain gliomas, and predicts prognosis and responses to immunotherapy

Frontiers in Pharmacology, 2022
Glioma is one of the most lethal cancers and causes more than 200,000 deaths every year. Immunotherapy was an inspiring therapy for multiple cancers but failed in glioma treatment.
Siliang Chen, Shuxin Zhang, Shuxin Zhang, Wentao Feng, Junhong Li, Yunbo Yuan, Wenhao Li, Zhihao Wang, Yuan Yang, Yanhui Liu   +9 more
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Metabolism and Regulatory Functions of O-Acetylserine, S-Adenosylmethionine, Homocysteine, and Serine in Plant Development and Environmental Responses

Frontiers in Plant Science, 2021
The metabolism of an organism is closely related to both its internal and external environments. Metabolites can act as signal molecules that regulate the functions of genes and proteins, reflecting the status of these environments. This review discusses
Mutsumi Watanabe, Yukako Chiba, Masami Yokota Hirai, Masami Yokota Hirai   +3 more
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Insights Into the Known 13C Depletion of Methane—Contribution of the Kinetic Isotope Effects on the Serine Hydroxymethyltransferase Reaction

Frontiers in Chemistry, 2022
We determined the kinetic isotope effect on the serine hydroxymethyltransferase reaction (SHMT), which provides important C1 metabolites that are essential for the biosynthesis of DNA bases, O-methyl groups of lignin and methane. An isotope effect on the
Gerd Gleixner
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Amino Acid Profile and Biological Properties of Silk Cocoon as Affected by Water and Enzyme Extraction

Molecules, 2021
We compared the efficacy for protein extraction of water versus enzymatic extraction. The amino-acid composition, inhibitory activity against enzymes α-amylase and α-glucosidase, and anti-glycation activities of silk protein extract (SPE) were determined.
Chuleeporn Bungthong, Colin Wrigley, Thanathat Sonteera, Sirithon Siriamornpun   +3 more
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Simultaneous suppression of PKM2 and PHGDH elicits synergistic anti-cancer effect in NSCLC

Frontiers in Pharmacology, 2023
Metabolic reprogramming is a hallmark of human cancer. Cancer cells exhibit enhanced glycolysis, which allows glycolytic intermediates to be diverted into several other biosynthetic pathways, such as serine synthesis.
Kaixuan Wang, Hao Lu, Xinmiao Wang, Qingxia Liu, Jinxia Hu, Yao Liu, Yao Liu, Meihua Jin, Dexin Kong   +8 more
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#BlackCharactersMatter: If I’m Trying to Teach for Social Justice, Why Do All the Black Men and Boys on my Syllabus Die?

Radical Teacher, 2020
In this essay combining first-person narrative and scholarly literature, a classroom teacher examines the ways in which, despite having a self-professed goal of teaching for social justice, her syllabus centers, upholds, and normalize default whiteness ...
Andrea Serine Avery
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Mapping the Substrate-Binding Sites in the Phosphatidylserine Synthase in Candida albicans

Frontiers in Cellular and Infection Microbiology, 2021
The fungal phosphatidylserine (PS) synthase, a membrane protein encoded by the CHO1 gene, is a potential drug target for pathogenic fungi, such as Candida albicans. However, both substrate-binding sites of C.
Yue Zhou, Chelsi D. Cassilly, Todd B. Reynolds   +2 more
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2,3-Diaminopropanols Obtained from d-Serine as Intermediates in the Synthesis of Protected 2,3-l-Diaminopropanoic Acid (l-Dap) Methyl Esters

Molecules, 2020
A synthetic strategy for the preparation of two orthogonally protected methyl esters of the non-proteinogenic amino acid 2,3-l-diaminopropanoic acid (l-Dap) was developed. In these structures, the base-labile protecting group 9-fluorenylmethyloxycarbonyl
Andrea Temperini, Donatella Aiello, Fabio Mazzotti, Constantinos M. Athanassopoulos, Pierantonio De Luca, Carlo Siciliano   +5 more
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Effects of insufficient serine on health and selenoprotein expression in rats and their offspring

Frontiers in Nutrition, 2022
ObjectiveTo observe the impact of insufficient exogenous and/or endogenous serine on selenoprotein expression and health of pregnant rats and their offspring.MethodExperiment 1 was conducted in male rats, in which the dose-dependent effects of serine on ...
Yiqun Liu, Jianrong Wang, Qin Wang, Feng Han, Lili Shi, Chao Han, Zhenwu Huang, Zhenwu Huang, Liang Xu   +8 more
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Mutation of Tyrosine Sites in the Human Alpha-Synuclein Gene Induces Neurotoxicity in Transgenic Mice with Soluble Alpha-Synuclein Oligomer Formation

Cells, 2022
Overexpression of α-synuclein with tyrosine mutated to phenylalanine at position 125 leads to a severe phenotype with motor impairment and neuropathology in Drosophila.
Louise Berkhoudt Lassen, Maj Schneider Thomsen, Elisa Basso, Ernst-Martin Füchtbauer, Annette Füchtbauer, Tiago Fleming Outeiro, Poul Henning Jensen, Torben Moos   +7 more
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