Results 251 to 260 of about 938,109 (291)

Efficient Production of Shinorine and Mycosporine-Glycine-Alanine in <i>Yarrowia lipolytica</i> Using Natural and Engineered Nonribosomal Peptide Synthetases. [PDF]

J Agric Food Chem
Lee D, Jin H, Kim S, Kim S, Park E, Yoo D, Hahn JS.   +6 more
europepmc   +1 more source

Podocyte RIPK3 Deletion Improves Diabetic Kidney Disease by Attenuating NF‐κB p65 Driven Inflammation

Advanced Science, EarlyView.
Prevention and treatment of diabetic kidney disease (DKD) have become a major global public health challenge. This study shed new light on the underlying pathogenic mechanisms of podocyte injury in DKD and highlights the therapeutic potential of mitigating podocyte injury through inhibition of the RIPK3/NF‐κB p65‐mediated inflammatory response as a ...
Lu'an Li, Jiaying Li, Ruizhao Li, Xingchen Zhao, Yuanhan Chen, Yating Cai, Yan Yang, Weiteng Wang, Siqi Zheng, Li Zhang, Xinling Liang   +10 more
wiley   +1 more source

Serine Octamer Clusters Direct the Chirality of Peptides Formed in Water Microdroplets. [PDF]

J Phys Chem A
Shira BA, Cooks RG.
europepmc   +1 more source

Targeted Intervention Strategies for Maternal–Offspring Transmission of Christensenellaceae in Pigs via a Deep Learning Model

Advanced Science, EarlyView.
This study deciphers maternal‐driven microbial transmission in pigs using a deep learning model (maternal–offspring microbial transmission model), identifying Christensenellaceae R‐7 group as a key transmitted taxon. Filtered galacto‐oligosaccharides‐targeted Christensenellaceae R‐7 group alters offspring microbial functions via maternal ...
Haibo Shen, Xiaokang Ma, Longlin Zhang, Hao Li, Jichang Zheng, Shengru Wu, Ke Zuo, Yulong Yin, Jing Wang, Bie Tan   +9 more
wiley   +1 more source

Editorial to the Special Issue "Glycine-(and D-Serine)-Related Neurotransmission: Promising Therapeutic Targets with Still Unsolved Problems". [PDF]

Biomedicines
Raiteri L.
europepmc   +1 more source

A Multi‐Property Optimizing Generative Adversarial Network for de novo Antimicrobial Peptide Design

Advanced Science, EarlyView.
A Multi‐Property Optimizing Generative Adversarial Network (MPOGAN) is proposed to iteratively learn the relationship between peptides and multiple properties using a dynamically dataset. As the quality of the dataset improves, MPOGAN's ability to design antimicrobial peptides (AMPs) with multiple desired properties is enhanced.
Jiaming Liu, Tao Cui, Tao Wang, Lishan Lin, Xi Zeng, Dazhi Lu, Shaoqing Jiao, Jun Wang, Xiaoyan Li, Shuyuan Xiao, Dongna Xie, Xuecheng Wang, Yongtian Wang, Xuequn Shang, Yinbo Niu, Zhongyu Wei, Jiajie Peng   +16 more
wiley   +1 more source

De Novo Serine Synthesis Is a Metabolic Vulnerability That Can Be Exploited to Overcome Sunitinib Resistance in Advanced Renal Cell Carcinoma. [PDF]

Cancer Res
Teisseire M, Sahu U, Parola J, Tsai MC, Vial V, Durivault J, Grépin R, Cormerais Y, Molina C, Gouraud A, Pagès G, Ben-Sahra I, Giuliano S.   +12 more
europepmc   +1 more source

Lipid Droplet‐Organized MDM2‐Mediated P53 Degradation: A Metabolic Switch Governing Diet‐Driven Tumor Progression

Advanced Science, EarlyView.
Tumor‐associated TP53 inactivation correlates with lipid droplet (LD) accumulation. High‐fat diets drive Cyb5r3‐Myh9‐mediated p53 enrichment on LD surfaces, accelerating its degradation while upregulating LD‐promoting factor CD36 expression to establish a feed‐forward loop. LD suppression or dietary intervention restores p53 and inhibits tumorigenesis,
Haiyang Liu, Lin Jing, Yixin Li, Jinxing Zhou, Xiaohui Cui, Sen Li, Shijie Yang, Fangming Kan, Junfeng Du, Wentao Zhong, Sheng Yu, Ning Wang, Xing Jia, Junhui Li, Pan Nie, Zhenzhong Chen, Ying Han, Lingxi Jiang, Xiyun Yan, Hongxia Duan, Baiyong Shen   +20 more
wiley   +1 more source