Results 81 to 90 of about 265,113 (235)

A guide to the types, structures, and multifaceted functions of matrix metalloproteinases in cancer

The FEBS Journal, EarlyView.
Matrix metalloproteinases (MMPs) orchestrate cancer progression and metastasis through proteolytic and non‐proteolytic actions. By remodeling the tumor microenvironment, enhancing growth factor availability, and modulating cell behavior, MMPs promote proliferation, migration or invasion, and epithelial‐to‐mesenchymal transition. Alongside extracellular
Zoi Piperigkou, Sylvia Mangani, Spyros Kremmydas, Nikolaos E. Koletsis, Nikos K. Karamanos   +4 more
wiley   +1 more source

Immunoproteomic analysis of the excretory-secretory products of Trichinella pseudospiralis adult worms and newborn larvae

Parasites & Vectors, 2017
Background The nematode Trichinella pseudospiralis is an intracellular parasite of mammalian skeletal muscle cells and exists in a non-encapsulated form. Previous studies demonstrated that T. pseudospiralis could induce a lower host inflammatory response.
Yang Wang, Xue Bai, Haichao Zhu, Xuelin Wang, Haining Shi, Bin Tang, Pascal Boireau, Xuepeng Cai, Xuenong Luo, Mingyuan Liu, Xiaolei Liu   +10 more
doaj   +1 more source

Motor Nucleus of the Trigeminal Nerve [PDF]

, 2008
This report contains a summary of expression patterns for genes that are enriched in the motor nucleus of the trigeminal nerve (V) of the pons. All data is derived from the Allen Brain Atlas (ABA) in situ hybridization mouse project. The structure's
Allen Institute for Brain Science, Angela L. Guillozet-Bongaarts, Lydia L. Ng, Nicholas A. Kostakis   +3 more
core   +2 more sources

Interactions between small leucine‐rich proteoglycans and proteases: implications for tissue homeostasis and pathology

The FEBS Journal, EarlyView.
Small leucine‐rich proteoglycans (SLRPs) are key modulators of extracellular matrix structure and signaling. Their proteolytic processing by MMPs (Matrix Metalloproteinases), ADAMTS (disintegrin and metalloprotease with thrombospondin motifs), and serine proteases generates bioactive fragments that regulate collagen remodeling, inflammation, and ...
Maria Konstantaraki, Lydia‐Nefeli Thrapsanioti, Aikaterini Berdiaki, Ioanna Spyridaki, Dragana Nikitovic   +4 more
wiley   +1 more source

Effect of microencapsulated organic acids-essential oils blend and protease on performance and gut health of broilers under nutritional challenges

Journal of Animal Science and Technology
This study examined the effects of microencapsulated organic acids and essential oils (EOA) combined with a protease (PRO) supplement on the growth performance and gut health of broilers subjected to nutritional challenges through a diet high in wheat ...
Pattaveekan Preesong, Preeda Lertwatcharasarakul, Koonphol Pongmanee, Akaradet Seemacharoensri, Glenmer Bathan Tactacan, Chanporn Chaosap, Yuwares Ruangpanit   +6 more
doaj   +1 more source

In vivo multiplex quantitative analysis of 3 forms of alpha melanocyte stimulating hormone in pituitary of prolyl endopeptidase deficient mice

Molecular Brain, 2009
Background In vitro reactions are useful to identify putative enzyme substrates, but in vivo validation is required to identify actual enzyme substrates that have biological meaning. To investigate in vivo effects of prolyl endopeptidase (PREP), a serine
Perroud Bertrand, Alvarado Rudy J, Espinal Glenda M, Morado Alex R, Phinney Brett S, Warden Craig H   +5 more
doaj   +1 more source

An update on the landscape of collagen bioactive fragments

The FEBS Journal, EarlyView.
The remodeling of the extracellular matrix releases collagen bioactive fragments, which exert molecular functions and regulate numerous biological processes via several signaling pathways. Here, we summarize the latest findings describing the roles of major bioactive fragments from collagens I, IV, VI, and XVIII in various physiological and ...
Sylvie Ricard‐Blum, Julie Fradette
wiley   +1 more source

A self-compartmentalizing hexamer serine protease from Pyrococcus Horikoshii: Substrate selection achieved through multimerization [PDF]

, 2013
Oligopeptidases impose a size limitation on their substrates, the mechanism of which has long been in debate. Here we present the structure of a hexameric serine protease, an oligopeptidase from Pyrococcus horikoshii (PhAAP), revealing a complex, self ...
Aertgeerts, Afonine, Anna Kiss-Szemán, Balázs Hornung, Biswal, Bjelkmar, Bosch, Cha, Chen, Chiti, Clark, Collaborative Computational Project, Number 4, Cowtan, Dobson, Duysen, Dóra K. Menyhárd, Eldrup, Emsley, Engel, Engel, Erlandsson, Franken, Fuxreiter, Fülöp, Goettig, Gábor Náray-Szabó, Harmat, Hess, Hiramatsu, Hofmann, Ilona Szamosi, Joshua-Tor, Juhász, Kabsch, Kim, Kim, Kiss, Kiss, Klarissza Domokos, Krisztina Rádi, Li, László Polgár, Mackerell, Maurer-Stroh, McLuskey, Medrano, Monincová, Monsellier, Murshudov, Naylor, Palmieri, Pathak, Polgár, Prokop, Richards, Richardson, Rould, Scaloni, Schmidt, Shan, Shan, Sheldrick, Soldi, Stefani, Szeltner, Szeltner, Szeltner, Thoms, Vagin, Vaguine, Veronika Harmat, Zhang, Zoltán Szeltner, Éva Tichy-Rács   +73 more
core   +1 more source

Proteolysis at the extracellular matrix interface: Molecular architects and regulators in health and disease

The FEBS Journal, EarlyView.
The extracellular matrix (ECM) is a dynamic scaffold that orchestrates tissue architecture and cellular communication. A critical but underexplored interplay between proteases and cluster of differentiation molecules (CD) governs ECM turnover and directs cell fate.
David Jurnečka, Matija Hrovatin, Bor Bokalj, Boris Turk   +3 more
wiley   +1 more source

Molecular basis of resistance to organophosphate insecticides in the New World screw-worm fly

Parasites & Vectors, 2020
Background The emergence of insecticide resistance is a fast-paced example of the evolutionary process of natural selection. In this study, we investigated the molecular basis of resistance in the myiasis-causing fly Cochliomyia hominivorax (Diptera ...
Sophie Tandonnet, Gisele Antoniazzi Cardoso, Pedro Mariano-Martins, Raquel Dietsche Monfardini, Vanessa A. S. Cunha, Renato Assis de Carvalho, Tatiana Teixeira Torres   +6 more
doaj   +1 more source