Results 101 to 110 of about 6,315 (155)

The mycobacteriophage Bxb1 integrase as a catalyst for DNA inversion in Saccharomyces cerevisiae [PDF]

, 2016
Synthetic biology aims to develop methods of genetic regulation not seen in nature to manipulate biological systems, allowing them to achieve incredibly complex feats of biotechnology.
Timmermans, Marshall
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N-terminal half of transportin SR2 interacts with HIV integrase

, 2017
The karyopherin transportin SR2 (TRN-SR2, TNPO3) is responsible for shuttling specific cargoes such as serine/arginine-rich splicing factors from the cytoplasm to the nucleus.
Stéphanie De Houwer, De Wit, Flore, Flore De Wit, Breemans, Jolien, Strelkov, Sergei, Debyser, Zeger, Tsirkone, Vicky, Frauke Christ, De Houwer, Stéphanie, Vicky G. Tsirkone, Zeger Debyser, Blokken, Jolien, Christ, Frauke, Jolien Blokken, Sergei V. Strelkov, Jolien Breemans   +15 more
core   +1 more source

The mutational analysis of C31 integrase

, 2007
The integrase protein from the bacteriophage ~C31 is a member of the large serine recombinase family. Purified ~C31 integrase has been shown to only catalyse site-specific recombination between the DNA sites attB and attP in vitro.
Rowley, Paul Andrew
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The role of single occupancy effects on integrase dynamics in a cell-free system [PDF]

, 2016
Phage integrase-based circuits are an alternative approach to relying on transcriptional and translational repression for biomolecular circuits. Previous research has shown that circuits based on integrases can perform a variety of functions, including ...
Hayes, Clarmyra A., Artavanis, Georgios, Hsiao, Victoria, Murray, Richard M.   +3 more
core  

Serine Integrase Structure and Function

The FASEB Journal, 2011
Gregory D Van Duyne, Karen Rutherford, Kushol Gupta   +2 more
openaire   +1 more source

Recognition ofrecombination sites by C31 integrase

, 2007
Streptomyces phage ~C3l produces a site-specific integrase by whiCh it is able to integrate its DNA into the host chromosome. ~C3l integrase belongs to the serine recombinase family and utilizes small (less than 50 base pair) substrates for recombination.
Gupta, Milind Kumar
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Repressing Integrase attachment site operation with CRISPR-Cas9 in E. coli [PDF]

, 2017
Serine integrases are bacteriophage proteins responsible for integrating the phage genome into that of the host. Synthetic biologists have co-opted these proteins into useful tools for permanent DNA logic, utilizing their specific DNA recombination ...
Shur, Andrey, Murray, Richard M.
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A hybrid lentivirus-transposon vector for safer gene therapy

, 2010
Gene therapy vectors based on the HIV-1 lentivirus are an attractive option for clinical applications because they enter a broad range of target cells efficiently and deliver stable gene expression through integration into host chromosomes.
Vink, C.A.
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Engineering and characterisation of hybrid Large Serine Recombinases as tools for probing determinants of DNA sequence specificity

Phage-derived serine integrases are members of the large serine recombinase (LSRs) family of sitespecific recombinases that mediate highly precise DNA recombination.
Lawson-Williams, M
core   +1 more source

Structural basis of second-generation HIV integrase inhibitor action and viral resistance

, 2020
Although second-generation HIV integrase strand-transfer inhibitors (INSTIs) are prescribed throughout the world, the mechanistic basis for the superiority of these drugs is poorly understood. We used single-particle cryo-electron microscopy to visualize
Abhay Kotecha (395425), Dénes Berta (9299171), Allison Ballandras-Colas (466946), Peter Cherepanov (369), Andrea Nans (5176226), Wen Li (143214), Nicola J Cook (8128392), Edina Rosta (1306173), Alan N Engelman (8128407), Magd Badaoui (5877179)   +9 more
core