FOXC1-mediated serine metabolism reprogramming enhances colorectal cancer growth and 5-FU resistance under serine restriction [PDF]
Cell Communication and SignalingColorectal cancer (CRC) is the most common gastrointestinal malignancy, and 5-Fluorouracil (5-FU) is the principal chemotherapeutic drug used for its treatment. However, 5-FU resistance remains a significant challenge.
Zhukai Chen +17 more
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The Intersection of Serine Metabolism and Cellular Dysfunction in Retinal Degeneration [PDF]
Cells, 2020 In the past, the importance of serine to pathologic or physiologic anomalies was inadequately addressed. Omics research has significantly advanced in the last two decades, and metabolomic data of various tissues has finally brought serine metabolism to ...
Tirthankar Sinha +3 more
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p63 orchestrates serine and one carbon metabolism enzymes expression in head and neck cancer [PDF]
Biology Direct, 2023 Background Head and neck squamous cell carcinoma (HNSCC) is characterized by high proliferation and limited differentiation. The altered expression of the p53 family members, and specifically of p63, represents a pivotal event in the pathogenesis of ...
Angela Cappello +9 more
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Classical swine fever virus inhibits serine metabolism-mediated antiviral immunity by deacetylating modified PHGDH [PDF]
mBioClassical swine fever virus (CSFV), an obligate intracellular pathogen, hijacks cellular metabolism to evade immune surveillance and facilitate its replication. The precise mechanisms by which CSFV modulates immune metabolism remain largely unknown.
Xiaowen Li +20 more
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Lactylation‐Driven IGF2BP3‐Mediated Serine Metabolism Reprogramming and RNA m6A—Modification Promotes Lenvatinib Resistance in HCC [PDF]
Advanced ScienceAcquired resistance remains a bottleneck for molecular‐targeted therapy in advanced hepatocellular carcinoma (HCC). Metabolic adaptation and epigenetic remodeling are recognized as hallmarks of cancer that may contribute to acquired resistance.
Yuanxiang Lu +10 more
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Serine Metabolism Tunes Immune Responses To Promote Oreochromis niloticus Survival upon Edwardsiella tarda Infection [PDF]
mSystems, 2021 Overactive immune response is a critical factor triggering host death upon bacterial infection. However, the mechanism behind the regulation of excessive immune responses is still largely unknown, and the corresponding control and preventive measures are
Dai-Xiao Yang +7 more
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An archaeal ADP-dependent serine kinase involved in cysteine biosynthesis and serine metabolism [PDF]
Nature Communications, 2016 Archaea metabolism has unique adaptations to hostile environments. Here Makino et al. describe an unusual ADP-dependent kinase that phosphorylates free serine to O-phosphoserine and participates in an additional cysteine biosynthetic pathway in the ...
Yuki Makino +6 more
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Serine Metabolism Supports Macrophage IL-1β Production. [PDF]
Cell Metab, 2019 Serine is a substrate for nucleotide, NADPH, and glutathione (GSH) synthesis. Previous studies in cancer cells and lymphocytes have shown that serine-dependent one-carbon units are necessary for nucleotide production to support proliferation. Presently, it is unknown whether serine metabolism impacts the function of non-proliferative cells, such as ...
Rodriguez AE +10 more
europepmc +4 more sources
Serine metabolism in aging and age-related diseases. [PDF]
GeroscienceNon-essential amino acids are often overlooked in biomedical research; however, they are crucial components of organismal metabolism. One such metabolite that is integral to physiological function is serine. Serine acts as a pivotal link connecting glycolysis with one-carbon and lipid metabolism, as well as with pyruvate and glutathione syntheses ...
Shan S, Hoffman JM.
europepmc +3 more sources
The breast cancer oncogene IKKε coordinates mitochondrial function and serine metabolism. [PDF]
EMBO Rep, 2020 Xu R +15 more
europepmc +2 more sources