Results 21 to 30 of about 245,013 (288)

Targeting HOTAIRM1 ameliorates glioblastoma by disrupting mitochondrial oxidative phosphorylation and serine metabolism. [PDF]

iScience, 2022
Han W, Wang S, Qi Y, Wu F, Tian N, Qiang B, Peng X.   +6 more
europepmc   +2 more sources

ZEB1 Fuels Serine Metabolism to Promote HCC Metastasis. [PDF]

Cell Mol Gastroenterol Hepatol, 2023
Chan FF, Wong CM.
europepmc   +3 more sources

ZNF526 drives tumor growth by enhancing SHMT1-dependent serine metabolism and antioxidant capability in TNBC. [PDF]

Mol Cancer
Qin W, Shao L, Li Q, Zhang D, Jia X, Dong C.   +5 more
europepmc   +2 more sources

l-Serine links metabolism with neurotransmission [PDF]

Progress in Neurobiology, 2021
Brain energy metabolism is often considered as a succession of biochemical steps that metabolize the fuel (glucose and oxygen) for the unique purpose of providing sufficient ATP to maintain the huge information processing power of the brain. However, a significant fraction (10-15 %) of glucose is shunted away from the ATP-producing pathway (oxidative ...
Maugard, Marianne, Vigneron, Pierre-Antoine, Bolaños, Juan, Bonvento, Gilles   +3 more
openaire   +3 more sources

TAMI-38. CYSTEINE-PROMOTING COMPOUNDS INDUCE MITOCHONDRIAL TOXICITY IN GLIOBLASTOMA THROUGH ALTERED PYRUVATE AND SERINE METABOLISM [PDF]

Neuro Oncol, 2020
Noch E, Palma L, Yim I, Binder B, Benedetti E, Krumsiek J, Elemento O, Cantley L.   +7 more
europepmc   +3 more sources

Targeting Asparagine and Serine Metabolism in Germinal Centre-Derived B Cells Non-Hodgkin Lymphomas (B-NHL). [PDF]

Cells, 2021
Eraslan Z, Papatzikas G, Cazier JB, Khanim FL, Günther UL.   +4 more
europepmc   +3 more sources

Glutathione Restricts Serine Metabolism to Preserve Regulatory T Cell Function. [PDF]

Cell Metab, 2020
Kurniawan H, Franchina DG, Guerra L, Bonetti L, -Baguet LS, Grusdat M, Schlicker L, Hunewald O, Dostert C, Merz MP, Binsfeld C, Duncan GS, Farinelle S, Nonnenmacher Y, Haight J, Das Gupta D, Ewen A, Taskesen R, Halder R, Chen Y, Jäger C, Ollert M, Wilmes P, Vasiliou V, Harris IS, Knobbe-Thomsen CB, Turner JD, Mak TW, Lohoff M, Meiser J, Hiller K, Brenner D.   +31 more
europepmc   +3 more sources

Linking Serine/Glycine Metabolism to Radiotherapy Resistance [PDF]

Cancers, 2021
The activation of de novo serine/glycine biosynthesis in a subset of tumors has been described as a major contributor to tumor pathogenesis, poor outcome, and treatment resistance. Amplifications and mutations of de novo serine/glycine biosynthesis enzymes can trigger pathway activation; however, a large group of cancers displays serine/glycine pathway
Sanchez-Castillo, Anais, Vooijs, Marc, Kampen, Kim R.   +2 more
openaire   +4 more sources

Serine-associated one-carbon metabolic reprogramming: a new anti-cancer therapeutic strategy

Frontiers in Oncology, 2023
Tumour metabolism is a major focus of cancer research, and metabolic reprogramming is an important feature of malignant tumours. Serine is an important non-essential amino acid, which is a main resource of one-carbon units in tumours.
Jing Zhang, Jian Bai, Chen Gong, Jianhua Wang, Yi Cheng, Jing Zhao, Huihua Xiong   +6 more
doaj   +1 more source

Serine metabolism in human pregnancy [PDF]

American Journal of Physiology-Endocrinology and Metabolism, 2003
Serine plays an important role in intermediary metabolism as a source of one carbon pool for nucleotide biosynthesis, as a precursor for glycine and glucose, and as a contributor to cysteine biosynthesis. A unique serine-glycine cycling between the liver and the placenta has been demonstrated in the sheep fetus. We hypothesized that, because of serine'
Satish C, Kalhan, Lourdes L, Gruca, Prabhu S, Parimi, Alicia, O'Brien, Leroy, Dierker, Ed, Burkett   +5 more
openaire   +2 more sources