Results 11 to 20 of about 372,460 (343)

Ionization behavior of the histidine residue in the catalytic triad of serine proteases [PDF]

, 1973
α-Lytic protease is a homologue of the mammalian serine proteases such as trypsin, chymotrypsin, and elastase, and its single histidine residue belongs to the Asp-His-Ser catalytic triad. This single histidine residue has been selectively enriched in the
Hunkapiller, Michael W., Richards, John H., Smallcombe, Stephen H., Whitaker, Don R.   +3 more
core   +2 more sources

The Effect of Serine Protease Inhibitors on Visceral Pain in Different Rodent Models With an Intestinal Insult

Frontiers in Pharmacology, 2022
Background: Serine proteases are believed to play a key role in the origin of abdominal pain in IBD and IBS. We previously demonstrated a reduction of visceral pain in a post-inflammatory IBS rat model after a single intraperitoneal or intracolonic ...
Hannah Ceuleers, Hannah Ceuleers, Hannah Ceuleers, Nikita Hanning, Nikita Hanning, Michelle De bruyn, Michelle De bruyn, Joris G De Man, Joris G De Man, Heiko U De Schepper, Heiko U De Schepper, Heiko U De Schepper, Qian Li, Liansheng Liu, Steven Abrams, Steven Abrams, Annemieke Smet, Annemieke Smet, Jurgen Joossens, Koen Augustyns, Koen Augustyns, Ingrid De Meester, Ingrid De Meester, Pankaj J Pasricha, Benedicte Y De Winter, Benedicte Y De Winter, Benedicte Y De Winter   +26 more
doaj   +1 more source

Identification and characterization of fusolisin, the Fusobacterium nucleatum autotransporter serine protease. [PDF]

PLoS ONE, 2014
Fusobacterium nucleatum is an oral anaerobe associated with periodontal disease, adverse pregnancy outcomes and colorectal carcinoma. A serine endopeptidase of 61-65 kDa capable of damaging host tissue and of inactivating immune effectors was detected ...
Lior Doron, Shunit Coppenhagen-Glazer, Yara Ibrahim, Amir Eini, Ronit Naor, Graciela Rosen, Gilad Bachrach   +6 more
doaj   +1 more source

New insights into the evolution of subtilisin-like serine protease genes in Pezizomycotina

BMC Evolutionary Biology, 2010
Background Subtilisin-like serine proteases play an important role in pathogenic fungi during the penetration and colonization of their hosts. In this study, we perform an evolutionary analysis of the subtilisin-like serine protease genes of subphylum ...
Zhang Ying, Liang Lianming, Yu Zefen, Tian Baoyu, Dong Linqian, Yang Jinkui, Yu Li, Li Juan, Wang Xu, Zhang Keqin   +9 more
doaj   +1 more source

Interdependence of kallikrein-related peptidases in proteolytic networks [PDF]

, 2010
Human kallikrein-related peptidases (KLKs) are 15 homologous serine proteases involved in several (patho)physiological processes, including cancer. Secreted as precursors, they are activated upon proteolytic release of a short propeptide. We searched for
Debela, Emami, Freije, Frenette, Gomis, Hollenberg, Itoh, Jung, Lopez, Ohler, Pampalakis, Ramsay, Ries, Rittenhouse, Ryu, Shaw, Sperl, Takayama, Takayama, Tye, Yoon, Yoon   +21 more
core   +1 more source

Serine proteases [PDF]

IUBMB Life, 2009
AbstractOver one third of all known proteolytic enzymes are serine proteases. Among these, the trypsins underwent the most predominant genetic expansion yielding the enzymes responsible for digestion, blood coagulation, fibrinolysis, development, fertilization, apoptosis, and immunity.
openaire   +4 more sources

Preliminary investigations on the serine and aspartic protease inhibitors from Nothopegia beddomei

Ceylon Journal of Science, 2019
Aqueous stem bark extract of Nothopegia beddomei was assayed for serine and aspartic protease inhibitors by using trypsin and pepsin as the target enzymes, respectively. Crude bark extract was dialyzed and subjected to inhibition assays.
M.G.K.P. Dayarathne, Sanath Rajapakse
doaj   +1 more source

Protean proteases: At the cutting edge of lung diseases [PDF]

, 2017
Proteases were traditionally viewed as mere protein-degrading enzymes with a very restricted spectrum of substrates. A major expansion in protease research has uncovered a variety of novel substrates, and it is now evident that proteases are critical ...
Borensztajn, Keren S., Cataldo, Didier, Heath, Nicole, Janciauskiene, Sabina, Lalmanach, Gilles, Ludwig, Andreas, Mall, Marcus A., Meiners, Silke, Overall, Christopher M., Schultz, Carsten, Taggart, Clifford, Turk, Boris   +11 more
core   +3 more sources

Protease inhibitors targeting coronavirus and filovirus entry. [PDF]

, 2015
In order to gain entry into cells, diverse viruses, including Ebola virus, SARS-coronavirus and the emerging MERS-coronavirus, depend on activation of their envelope glycoproteins by host cell proteases.
Agudelo, Juliet, Barnard, Dale, Carrion, Ricardo, Lu, Kai, McKerrow, James H, Nunneley, Jerritt W, Pöhlmann, Stefan, Renslo, Adam R, Simmons, Graham, Vedantham, Punitha, Zhou, Yanchen   +10 more
core   +1 more source

The mitochondrial protease HtrA2 restricts the NLRP3 and AIM2 inflammasomes. [PDF]

, 2018
Activation of the inflammasome pathway is crucial for effective intracellular host defense. The mitochondrial network plays an important role in inflammasome regulation but the mechanisms linking mitochondrial homeostasis to attenuation of inflammasome ...
Alnemri, Emad S., Champagne, Claudia, Doiron, Karine, Douglas, Todd, Leiva-Torres, Gabriel André, Mayes, Lindsey, Rodrigue-Gervais, Ian Gaël, Saleh, Maya, Vanié, Paulin, Vidal, Silvia M.   +9 more
core   +3 more sources