Results 41 to 50 of about 358,313 (362)
Mast cells limit extracellular levels of IL-13 via a serglycin proteoglycan-serine protease axis [PDF]
, 2012 Mast cell (MC) granules contain large amounts of proteases of the chymase, tryptase and carboxypeptidase A (MC-CPA) type that are stored in complex with serglycin, a proteoglycan with heparin side chains.
Feyerabend, TB +8 more
core +1 more source
SjAPI, the first functionally characterized Ascaris-type protease inhibitor from animal venoms. [PDF]
PLoS ONE, 2013 Serine protease inhibitors act as modulators of serine proteases, playing important roles in protecting animal toxin peptides from degradation. However, all known serine protease inhibitors discovered thus far from animal venom belong to the Kunitz-type ...
Zongyun Chen +7 more
doaj +1 more source
Structure of the Human Cytomegalovirus Protease Catalytic Domain Reveals a Novel Serine Protease Fold and Catalytic Triad [PDF]
, 1996 Proteolytic processing of capsid assembly protein precursors by herpesvirus proteases is essential for virion maturation. A 2.5 Å crystal structure of the human cytomegalovirus protease catalytic domain has been determined by X-ray diffraction.
Almassy, Robert J. +9 more
core +1 more source
SmSP2: A serine protease secreted by the blood fluke pathogen Schistosoma mansoni with anti-hemostatic properties. [PDF]
, 2018 BackgroundSerine proteases are important virulence factors for many pathogens. Recently, we discovered a group of trypsin-like serine proteases with domain organization unique to flatworm parasites and containing a thrombospondin type 1 repeat (TSR-1 ...
Caffrey, Conor R +13 more
core +2 more sources
Reelin Is a Serine Protease of the Extracellular Matrix [PDF]
Journal of Biological Chemistry, 2002 Reelin is an extracellular matrix protein that plays a pivotal role in development of the central nervous system. Reelin is also expressed in the adult brain, notably in the cerebral cortex, where it might play a role in synaptic plasticity. The mechanism of action of reelin at the molecular level has been the subject of several hypotheses.
Maria Giulia Farace +7 more
openaire +8 more sources
Journal of Integrative Agriculture, 2023 The serine proteases of Mycobacteria tuberculosis (Mtb) are important contributors to the process of bacterial invasion and its pathogenesis. In the present study, we systematically characterized the role of the Rv1043c protein in Mycobacterium infection
Yang-yang TANG +6 more
doaj
Carica papaya Leaf Extract Inhibits SARS-CoV-2 Main Proteases but not Human TMPRSS2: An In-vitro and In-silico Study [PDF]
arXiv, 2022 Carica papaya (CP) leaf is long known for its traditional pharmacological effects against dengue virus and malaria. Therefore, CP could also be a potential solution for the treatment of other infectious diseases, such as coronavirus. In this study, we evaluate the potential effect of the ethanolic CP leaf extract in inhibiting the enzymatic activity of
arxiv
Four small puzzles that Rosetta doesn't solve [PDF]
Das R (2011) Four Small Puzzles That Rosetta Doesn't Solve. PLoS
ONE 6(5): e20044, 2011 A complete macromolecule modeling package must be able to solve the simplest structure prediction problems. Despite recent successes in high resolution structure modeling and design, the Rosetta software suite fares poorly on deceptively small protein and RNA puzzles, some as small as four residues.
arxiv +1 more source
Serine proteases, serine protease inhibitors, and protease-activated receptors: Roles in synaptic function and behavior [PDF]
Brain Research, 2011 Serine proteases, serine protease inhibitors, and protease-activated receptors have been intensively investigated in the periphery and their roles in a wide range of processes-coagulation, inflammation, and digestion, for example-have been well characterized (see Coughlin, 2000; Macfarlane et al., 2001; Molinari et al., 2003; Wang et al., 2008; Di Cera,
Antoine G. Almonte, J. David Sweatt
openaire +3 more sources
Molecules, 2011 A ‘Heat treatment aqueous two phase system’ was employed for the first time to purify serine protease from kesinai (Streblus asper) leaves. In this study, introduction of heat treatment procedure in serine protease purification was investigated.
Shuhaimi Mustafa +2 more
doaj +1 more source