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Functions and evolution of FAM111 serine proteases [PDF]
Frontiers in Molecular Biosciences, 2022 Proteolysis plays fundamental and regulatory roles in diverse cellular processes. The serine protease FAM111A (FAM111 trypsin-like peptidase A) emerged recently as a protease involved in two seemingly distinct processes: DNA replication and antiviral ...
Allison L. Welter +2 more
doaj +4 more sources
Functional analysis of a missense mutation in the serine protease inhibitor SPINT2 associated with congenital sodium diarrhea. [PDF]
PLoS ONE, 2014 Membrane-bound serine proteases play important roles in different biological processes. Their regulation by endogenous inhibitors is poorly understood.
Nicolas Faller +2 more
doaj +10 more sources
Ionization Behavior of the Histidine Residue in the Catalytic Triad of Serine Proteases [PDF]
, 1973 α-Lytic protease is a homologue of the mammalian serine proteases such as trypsin, chymotrypsin, and elastase, and its single histidine residue belongs to the Asp-His-Ser catalytic triad. This single histidine residue has been selectively enriched in the
Michael W. Hunkapiller +3 more
openalex +3 more sources
Serine Proteases of Parasitic Helminths
The Korean Journal of Parasitology, 2015 Serine proteases form one of the most important families of enzymes and perform significant functions in a broad range of biological processes, such as intra- and extracellular protein metabolism, digestion, blood coagulation, regulation of development ...
Yong Yang +6 more
semanticscholar +4 more sources
Novel inhibitors and activity-based probes targeting serine proteases [PDF]
Frontiers in Chemistry, 2022 Serine proteases play varied and manifold roles in important biological, physiological, and pathological processes. These include viral, bacterial, and parasitic infection, allergic sensitization, tumor invasion, and metastasis. The use of activity-based
Timothy E. G. Ferguson +3 more
doaj +2 more sources
eLife, 2021 Coronavirus entry is mediated by the spike protein that binds the receptor and mediates fusion after cleavage by host proteases. The proteases that mediate entry differ between cell lines, and it is currently unclear which proteases are relevant in vivo.
Anna Z Mykytyn +7 more
doaj +2 more sources
Natural serine proteases and their applications in combating amyloid formation [PDF]
ADMET and DMPKBackground and purpose: Amyloidosis is a group of diseases including diabetes type II and neurological disorders, such as Alzheimer’s disease, Parkinson’s disease, prion disease, etc., where a common trait is observed; accumulation of misfolded protein ...
Sanjay Metkar +3 more
doaj +2 more sources
Sequence and phylogenetic analysis of viper venom serine proteases [PDF]
Bioinformation, 2012 Snakebites are a major neglected tropical disease responsible for as many as 95000 deaths every year worldwide. Viper venom serine proteases disrupt haemostasis of prey and victims by affecting various stages of the blood coagulation system.
Gibbins, Jonathon M. +3 more
core +2 more sources
Staphylococcal SplA and SplB serine proteases target ubiquitin(-like) specific proteases [PDF]
AMB ExpressStaphylococcus aureus is a Gram-positive opportunistic pathogen that has colonized nearly 30% of the human population and can cause life-threatening infections. S. aureus exports a variety of virulence factors, such as a novel set of extracellular serine
Felix L. Glinka +13 more
doaj +2 more sources
Serine proteases and metalloproteases are highly increased in irritable bowel syndrome Tunisian patients [PDF]
Scientific Reports, 2023 Serine proteases are involved in many biological processes and are associated with irritable bowel syndrome (IBS) pathology. An increase in serine protease activity has been widely reported in IBS patients.
Souha Soussou +10 more
doaj +2 more sources