Results 1 to 10 of about 183,910 (327)

Novel inhibitors and activity-based probes targeting serine proteases [PDF]

Frontiers in Chemistry, 2022
Serine proteases play varied and manifold roles in important biological, physiological, and pathological processes. These include viral, bacterial, and parasitic infection, allergic sensitization, tumor invasion, and metastasis. The use of activity-based
Timothy E. G. Ferguson, James A. Reihill, S. Lorraine Martin, Brian Walker   +3 more
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Natural serine proteases and their applications in combating amyloid formation [PDF]

ADMET and DMPK
Background and purpose: Amyloidosis is a group of diseases including diabetes type II and neurological disorders, such as Alzheimer’s disease, Parkinson’s disease, prion disease, etc., where a common trait is observed; accumulation of misfolded protein ...
Sanjay Metkar, Saranya Udayakumar, Agnishwar Girigoswami, Koyeli Girigoswami   +3 more
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Staphylococcal SplA and SplB serine proteases target ubiquitin(-like) specific proteases [PDF]

AMB Express
Staphylococcus aureus is a Gram-positive opportunistic pathogen that has colonized nearly 30% of the human population and can cause life-threatening infections. S. aureus exports a variety of virulence factors, such as a novel set of extracellular serine
Felix L. Glinka, Ole Schmöker, Abhishek K. Singh, Leif Steil, Christian Hentschker, Uwe Völker, Dominique Böttcher, Michael Lammers, Clemens Cammann, Ulrike Seifert, Elke Krüger, Michael Naumann, Barbara M. Bröker, Uwe T. Bornscheuer   +13 more
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Serine proteases and metalloproteases are highly increased in irritable bowel syndrome Tunisian patients [PDF]

Scientific Reports, 2023
Serine proteases are involved in many biological processes and are associated with irritable bowel syndrome (IBS) pathology. An increase in serine protease activity has been widely reported in IBS patients.
Souha Soussou, Amin Jablaoui, Vincent Mariaule, Aicha Kriaa, Houda Boudaya, Magdalena Wysocka, Ali Amouri, Ali Gargouri, Adam Lesner, Emmanuelle Maguin, Moez Rhimi   +10 more
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The Versatility of Serine Proteases from Brazilian Bothrops Venom: Their Roles in Snakebites and Drug Discovery [PDF]

Biomolecules
Serine proteases are multifunctional and versatile venom components found in viper snakes, including the Bothrops species, a widely distributed genus notorious for causing the highest number of snakebites across Latin America. These enzymes, representing
Marcela Romanazzi, Eloise T. M. Filardi, Geovanna M. M. Pires, Marcos F. Cerveja, Guilherme Melo-dos-Santos, Isadora S. Oliveira, Isabela G. Ferreira, Felipe A. Cerni, Norival Alves Santos-Filho, Wuelton M. Monteiro, José R. Almeida, Sakthivel Vaiyapuri, Manuela B. Pucca   +12 more
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Exploring the Diversity and Function of Serine Proteases in Toxicofera Reptile Venoms: A Comprehensive Overview [PDF]

Toxins
Toxicofera reptile venoms are composed of several toxins, including serine proteases. These proteases are glycosylated enzymes that affect the prey’s hemostatic system. Their actions extend across the coagulation cascade, the kallikrein–kinin system, and
Julia F. D. Vidal, Matheus F. Schwartz, Aisel V. Garay, Napoleão F. Valadares, Renata V. Bueno, Ana Carolina L. Monteiro, Sônia Maria de Freitas, João Alexandre R. G. Barbosa   +7 more
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Airborne indoor allergen serine proteases and their contribution to sensitisation and activation of innate immunity in allergic airway disease [PDF]

European Respiratory Review
Common airborne allergens (pollen, animal dander and those from fungi and insects) are the main triggers of type I allergic disorder in the respiratory system and are associated with allergic rhinitis, allergic asthma, as well as immunoglobulin E (IgE ...
Xuan Ouyang, James A. Reihill, Lisa E.J. Douglas, S. Lorraine Martin   +3 more
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Design, synthesis, and evaluation of Bothrops venom serine protease peptidic inhibitors [PDF]

Journal of Venomous Animals and Toxins including Tropical Diseases, 2021
Background: In Central and South America, snakebite envenomation is mainly caused by Bothrops spp. snakes, whose venoms feature significant biochemical richness, including serine proteases.
Gloria Maria da Silva, Daniel Henrique Berto de Souza, Karoline B. Waitman, Matteo Celano Ebram, Melissa R. Fessel, Iuliu Cezar Zainescu, Fernanda C. Portaro, Montse Heras, Sonia A. de Andrade   +8 more
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Pneumococcal Extracellular Serine Proteases: Molecular Analysis and Impact on Colonization and Disease

Frontiers in Cellular and Infection Microbiology, 2021
The pathobiont Streptococcus pneumoniae causes life-threatening diseases, including pneumonia, sepsis, meningitis, or non-invasive infections such as otitis media.
Murtadha Q. Ali, Thomas P. Kohler, Lukas Schulig, Gerhard Burchhardt, Sven Hammerschmidt   +4 more
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Peptidyl Activity-Based Probes for Imaging Serine Proteases

Frontiers in Chemistry, 2021
Proteases catalyze the hydrolysis of peptide bonds. Products of this breakdown mediate signaling in an enormous number of biological processes. Serine proteases constitute the most numerous group of proteases, accounting for 40%, and they are prevalent ...
Paulina Kasperkiewicz
doaj   +1 more source