Results 31 to 40 of about 103,544 (298)

Airway proteolytic control of pneumococcal competence.

PLoS Pathogens, 2023
Streptococcus pneumoniae is an opportunistic pathogen that colonizes the upper respiratory tract asymptomatically and, upon invasion, can lead to severe diseases including otitis media, sinusitis, meningitis, bacteremia, and pneumonia.
Haley Echlin, Amy Iverson, Ugo Sardo, Jason W Rosch   +3 more
doaj   +1 more source

Seprase: An overview of an important matrix serine protease [PDF]

, 2008
Seprase or Fibroblast Activation Protein (FAP) is an integral membrane serine peptidase, which has been shown to have gelatinase activity. Seprase has a dual function in tumour progression.
O\u27Brien, Pamela, O'Brien, Pamela, O'Connor, Brendan, O\u27Connor, Brendan   +3 more
core   +1 more source

New insights into the evolution of subtilisin-like serine protease genes in Pezizomycotina

BMC Evolutionary Biology, 2010
Background Subtilisin-like serine proteases play an important role in pathogenic fungi during the penetration and colonization of their hosts. In this study, we perform an evolutionary analysis of the subtilisin-like serine protease genes of subphylum ...
Zhang Ying, Liang Lianming, Yu Zefen, Tian Baoyu, Dong Linqian, Yang Jinkui, Yu Li, Li Juan, Wang Xu, Zhang Keqin   +9 more
doaj   +1 more source

Independent Subtilases Expansions in Fungi Associated with Animals [PDF]

, 2011
Many socially important fungi encode an elevated number of subtilisin-like serine proteases, which have been shown to be involved in fungal mutualisms with grasses and in parasitism of insects, nematodes, plants, other fungi, and mammalian skin.
P. Szczesny, Muszewska, Anna, Taylor, John W., J. W. Taylor, Grynberg, Marcin, A. Muszewska, Szczesny, Pawel, M. Grynberg   +7 more
core   +1 more source

T-SP1: a novel serine protease-like protein predominantly expressed in testis [PDF]

, 2008
Here, we describe a novel member in the group of membrane-anchored chymotrypsin (S1)-like serine proteases, namely testis serine protease 1 (T-SP1), as it is principally expressed in testis tissue.
Nerlich, Andreas, Profanter, Birgit, Geissler, Claudia, Neth, Peter, Sommerhoff, Christian P., Naegler, Dorit K., Jochum, Marianne   +6 more
core   +1 more source

SARS-CoV-2 entry into human airway organoids is serine protease-mediated and facilitated by the multibasic cleavage site

eLife, 2021
Coronavirus entry is mediated by the spike protein that binds the receptor and mediates fusion after cleavage by host proteases. The proteases that mediate entry differ between cell lines, and it is currently unclear which proteases are relevant in vivo.
Anna Z Mykytyn, Tim I Breugem, Samra Riesebosch, Debby Schipper, Petra B van den Doel, Robbert J Rottier, Mart M Lamers, Bart L Haagmans   +7 more
doaj   +1 more source

Interdependence of kallikrein-related peptidases in proteolytic networks [PDF]

, 2010
Human kallikrein-related peptidases (KLKs) are 15 homologous serine proteases involved in several (patho)physiological processes, including cancer. Secreted as precursors, they are activated upon proteolytic release of a short propeptide. We searched for
Burkhart, Julia M., Schwarz, Amelie, Christian Ries, Utzschneider, Daniel, Karolina Plaza, Debela, M., Amelie Schwarz, Plaza, Karolina, Beaufort, Nathalie, Creutzburg, Sabine, Ries, C., Schmitt, M., Burkhart, J. M., Beaufort, N., Plaza, K., Ries, Christian, Schwarz, A., Sabine Creutzburg, Mekdes Debela, Creutzburg, S., Schmitt, Manfred, Utzschneider, D., Julia M. Burkhart, Magdolen, Viktor, Debela, Mekdes, Viktor Magdolen, Nathalie Beaufort, Magdolen, V.   +27 more
core   +1 more source

The epidermolytic toxins are serine proteases [PDF]

FEBS Letters, 1990
Certain strains of Staphylococcus aureus usually belonging to phage group II produce epidermolytic toxins (ETA and ETB) which cause intraepidermal splitting in mice, neonates and occasionally adults. Amino acid sequences of ETA and ETB have been reported but the mechanism of epidermolysis remains unknown.
Dancer, Stephanie J., Garratt, Richard, Saldanha, Jose, Jhoti, Harren, Evans, Robert   +4 more
openaire   +2 more sources

Engineering novel complement activity into a pulmonary surfactant protein [PDF]

, 2010
Complement neutralizes invading pathogens, stimulates inflammatory and adaptive immune responses, and targets non- or altered-self structures for clearance.
Toth, Julia, Wilhelm J. Schwaeble, Christopher Furze, Russell Wallis, Keeble, A. H., Julia Toth, Keeble, Anthony H., Girija, Umakhanth Venkatraman, Wallis, Russell, Mitchell, D. A., Daniel A. Mitchell, Toth, J., Schwaeble, W. J., Schwaeble, Wilhelm J., Anthony H. Keeble, Furze, C., Umakhanth Venkatraman Girija, Furze, Christopher M., Mitchell, Daniel A., Wallis, R., Venkatraman Girija, U.   +20 more
core   +1 more source

Serine Proteases of Malaria Parasite Plasmodium falciparum: Potential as Antimalarial Drug Targets

Interdisciplinary Perspectives on Infectious Diseases, 2014
Malaria is a major global parasitic disease and a cause of enormous mortality and morbidity. Widespread drug resistance against currently available antimalarials warrants the identification of novel drug targets and development of new drugs.
Asrar Alam
doaj   +1 more source