Results 81 to 90 of about 103,544 (298)
Signaling pathways induced by serine proteases to increase intestinal epithelial barrier function. [PDF]
PLoS ONE, 2017 Changes in barrier function of the gastrointestinal tract are thought to contribute to the inflammatory bowel diseases Crohn's disease and ulcerative colitis.
Kelcie A Lahey +6 more
doaj +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Virtual Screening of Transmembrane Serine Protease Inhibitors
Bio-Protocol, 2017 The human family of type II transmembrane serine proteases includes 17 members. The defining features of these proteases are an N-terminal transmembrane domain and a C-terminal serine protease of the chymotrypsin (S1) fold, separated from each other by a
Antti Poso +2 more
doaj +1 more source
TMPRSS4, a type II transmembrane serine protease, as a potential therapeutic target in cancer
Experimental and Molecular Medicine, 2023 Proteases are involved in almost all biological processes, implying their importance for both health and pathological conditions. Dysregulation of proteases is a key event in cancer.
Semi Kim
doaj +1 more source
Midgut proteases from larval spodoptera littoralis (lepidoptera: noctutoae) [PDF]
, 1992 The presence and properties of proteases present in larval midgut extracts from Spodoptera littoralis was investigated. Trypsin and chymotrypsin activities were found mainly in the midgut lumen while leucine aminopeptidase and dipeptidyl aminopeptidase ...
Lee, Michael James, Lee, M.J
core
HtrA serine proteases as potential therapeutic targets in cancer
, 2009 The human HtrA family of serine proteases consists of four members: HtrA1, HtrA2, HtrA3 and HtrA4. Although prokaryotic HtrA proteins are well characterized in their dual roles as chaperones and proteases that degrade misfolded proteins in the periplasm,
CHIEN J +3 more
core +1 more source
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
PLoS PathogensCoronaviruses not only hijack host cells to serve as viral factories but also exploit host proteolytic systems to activate their spike (S) protein, the key glycoprotein mediating receptor binding and membrane fusion.
Bixia Chen +5 more
doaj +1 more source
Serine proteases in bone disease
, 2009 Serine proteases are active in many physiological and pathological processes within bone tissue. Although essential to adequate maintenance of bone and cartilage, their inappropriate expression can lead to exacerbation of tissue destruction and ...
Timson, David J. +3 more
core +1 more source