Results 181 to 190 of about 103,544 (298)

Targeting neutrophil serine proteases in bronchiectasis. [PDF]

Eur Respir J
Chalmers JD, Mall MA, Chotirmall SH, O'Donnell AE, Flume PA, Hasegawa N, Ringshausen FC, Watz H, Xu JF, Shteinberg M, McShane PJ.   +10 more
europepmc   +1 more source

The Activity of Metalloproteases and Serine Proteases in Various Organs after Leiurus macroctenus Envenomation. [PDF]

J Toxicol, 2023
Gunas V, Maievskyi O, Raksha N, Vovk T, Savchuk O, Shchypanskyi S, Gunas I.   +6 more
europepmc   +1 more source

Astrocytic FDX1 Contributes to Copper Dyshomeostasis‐associated Synaptic Dysfunction in Depression and Is Modulated by Exercise

Advanced Science, EarlyView.
Chronic stress disrupts copper homeostasis and promotes copper accumulation in the prelimbic cortex, leading to astrocytic FDX1 upregulation. Elevated astrocytic FDX1 impairs calcium signaling, induces structural atrophy, and disrupts synaptic function, contributing to depressive‐like behaviors. Physical exercise reverses these alterations by restoring
Lina Gao, Rongji Hui, Zhibo Tang, Tao Feng, Zhihang Hu, Xiaoqing Zhang, Ping Jiang, Hui Zhao, Kwok‐Fai So, Tianyuan Luo, Yanzhou Chang, Lan Yan   +11 more
wiley   +1 more source

TDP‐43 Aggregation: The Healthy‐Toxic Balance of the Prion‐Like Domain

Advanced Science, EarlyView.
TDP‐43 function relies on a delicate balance between reversible phase‐separated states and irreversible aggregation. Under physiological conditions, TDP‐43 forms dynamic droplets and oligomers that support normal cellular functions. In pathological contexts, this balance shifts toward aberrant aggregation, leading to toxic species.
Luca Zangrando, Emanuele Buratti, Francesca Paron   +2 more
wiley   +1 more source

Comparative immunodiagnostic evaluation of recombinant serine proteases from <i>Trichinella spiralis</i> and <i>Trichinella nativa</i> for early detection of trichinellosis. [PDF]

Vet World
Zhumalin A, Gajimuradova A, Bulashev A, Akibekov O, Syzdykova A, Gubaidullin N, Tosini F, Zhagipar F, Aydin A, Askarova N.   +9 more
europepmc   +1 more source

Serum mannan-binding lectin-associated serine proteases in early pregnancy for gestational diabetes in Chinese pregnant women. [PDF]

Front Endocrinol (Lausanne), 2023
Gao M, Li J, Zhang R, Li N, Li W, Zhang S, Wang P, Wang H, Fang Z, Yu Z, Hu G, Leng J, Yang X.   +12 more
europepmc   +1 more source

T2T Genome Assembly and Multi‐Omics Data Reveal Terrestrial Adaptation and Mucus Biosynthesis in Tropical Leatherleaf Slug (Laevicaulis alte)

Advanced Science, EarlyView.
A gap‐free genome assembly and multi‐omics comparison of the terrestrial slug Laevichaulis alte with an aquatic relative reveal that expansion of the VEGF family orchestrates mucus production, lipid metabolism, and immune defense—highlighting key molecular innovations for conquering life on land.
Gang Wang, Shaofang He, Zhongkai Wang, Aobo Pang, Xiaoli Sun, Rongchen Liu, Fang Wang, Sisi Chen, Zhijuan Bian, Dongcheng Wei, Liuhan Wu, Siyao Zhao, Qiuting Ji, Yiqi Sun, Niying Sun, Yushinta Fujaya, Boping Tang, Kianann Tan, Daizhen Zhang, Lianfu Chen   +19 more
wiley   +1 more source

Conserved structural topologies in RNase A-like and trypsin-like serine proteases: a sequence-based folding analysis. [PDF]

BMC Mol Cell Biol
Kabir KMA, Takahashi T, Kikuchi T.
europepmc   +1 more source

Correction: Simultaneous inhibition of two neutrophil serine proteases by the S. aureus innate immune evasion protein EapH2. [PDF]

J Biol Chem, 2023
Mishra N, Herdendorf TJ, Prakash O, Geisbrecht BV.   +3 more
europepmc   +1 more source

NAD+ Metabolism Licenses Zygotic Genome Activation via PARP7‐Mediated ADP‐Ribosylation of UHRF1 in Mouse Early Embryos

Advanced Science, EarlyView.
This study uncovers a metabolic‐epigenetic axis licensing zygotic genome activation (ZGA) in mouse embryos. A developmental decline in NAD+ levels activates PARP7, which mono‐ADP‐ribosylates and stabilizes UHRF1. This modification promotes the establishment of permissive histone acetylation marks, thereby facilitating timely ZGA.
Guangyi Cao, Ziqi Zhang, Anqi Chen, Yanbo Liu, Yuling Lin, Lina Yu, Ruixin Shi, Aolei Guo, Yan Mao, Ganggui Lou, Chaojun Li, Luhong Wen, Guijun Yan, Haixiang Sun   +13 more
wiley   +1 more source