Reelin Is a Serine Protease of the Extracellular Matrix [PDF]
Journal of Biological Chemistry, 2002 Reelin is an extracellular matrix protein that plays a pivotal role in development of the central nervous system. Reelin is also expressed in the adult brain, notably in the cerebral cortex, where it might play a role in synaptic plasticity. The mechanism of action of reelin at the molecular level has been the subject of several hypotheses.
Maria Giulia Farace +7 more
openaire +8 more sources
Cross genome comparisons of serine proteases in Arabidopsis and rice
BMC Genomics, 2006 Background Serine proteases are one of the largest groups of proteolytic enzymes found across all kingdoms of life and are associated with several essential physiological pathways.
Sowdhamini R, Tripathi Lokesh P
doaj +1 more source
Frontiers in Immunology, 2022 Phenoloxidase (PO)–catalyzed melanization is a vital immune response in insects for defense against pathogen infection. This process is mediated by clip domain serine proteases and regulated by members of the serpin superfamily. We here revealed that the
Jiayue Ji +6 more
doaj +1 more source
A new subfamily of fungal subtilases: structural and functional analysis of a Pleurotus ostreatus member [PDF]
, 2005 Pleurotus ostreatus produces several extracellular proteases which are believed to be involved in the regulation of the ligninolytic activities of this fungus. Recently, purification and characterization of the most abundant P.
FARACO, VINCENZA +5 more
core +2 more sources
The Role of Serine Proteases and Antiproteases in the Cystic Fibrosis Lung
Mediators of Inflammation, 2015 Cystic fibrosis (CF) lung disease is an inherited condition with an incidence rate of approximately 1 in 2500 new born babies. CF is characterized as chronic infection of the lung which leads to inflammation of the airway.
M. Twigg +5 more
semanticscholar +1 more source
Serpin functions in host-pathogen interactions [PDF]
PeerJ, 2018 Serpins are a broadly distributed superfamily of protease inhibitors that are present in all kingdoms of life. The acronym, serpin, is derived from their function as potent serine proteases inhibitors.
Jialing Bao +5 more
doaj +2 more sources
Removal of luminal content protects the small intestine during hemorrhagic shock but is not sufficient to prevent lung injury. [PDF]
, 2013 The small intestine plays a key role in the pathogenesis of multiple organ failure following circulatory shock. Current results show that reduced perfusion of the small intestine compromises the mucosal epithelial barrier, and the intestinal contents ...
Altshuler, Angelina E +5 more
core +2 more sources
Pollens destroy respiratory epithelial cell anchors and drive alphaherpesvirus infection [PDF]
, 2019 Pollens are well-known triggers of respiratory allergies and asthma. The pollen burden in today's ambient air is constantly increasing due to rising climate change and air pollution.
Gevaert, Kris +6 more
core +3 more sources
Host and bacterial proteases influence biofilm formation and virulence in a murine model of enterococcal catheter-associated urinary tract infection [PDF]
, 2017 Urinary tract infections: targeting enzymes might help Identifying bacterial and host enzymes that support biofilm formation may help prevent urinary tract infections caused by catheters.
Caparon, Michael G +5 more
core +3 more sources
Potential Therapeutic Targeting of Coronavirus Spike Glycoprotein Priming
Molecules, 2020 Processing of certain viral proteins and bacterial toxins by host serine proteases is a frequent and critical step in virulence. The coronavirus spike glycoprotein contains three (S1, S2, and S2′) cleavage sites that are processed by human host proteases.
Elisa Barile +5 more
doaj +1 more source