Results 11 to 20 of about 226,366 (284)
Novel inhibitors and activity-based probes targeting serine proteases [PDF]
Frontiers in Chemistry, 2022 Serine proteases play varied and manifold roles in important biological, physiological, and pathological processes. These include viral, bacterial, and parasitic infection, allergic sensitization, tumor invasion, and metastasis. The use of activity-based
Timothy E. G. Ferguson +3 more
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Natural serine proteases and their applications in combating amyloid formation [PDF]
ADMET and DMPKBackground and purpose: Amyloidosis is a group of diseases including diabetes type II and neurological disorders, such as Alzheimer’s disease, Parkinson’s disease, prion disease, etc., where a common trait is observed; accumulation of misfolded protein ...
Sanjay Metkar +3 more
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IUBMB Life, 2009 AbstractOver one third of all known proteolytic enzymes are serine proteases. Among these, the trypsins underwent the most predominant genetic expansion yielding the enzymes responsible for digestion, blood coagulation, fibrinolysis, development, fertilization, apoptosis, and immunity.
Enrico Di Cera
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Extracellular Pneumococcal Serine Proteases Affect Nasopharyngeal Colonization [PDF]
Frontiers in Cellular and Infection Microbiology, 2021 Streptococcus pneumoniae has evolved versatile strategies to colonize the nasopharynx of humans. Colonization is facilitated by direct interactions with host cell receptors or via binding to components of the extracellular matrix.
Murtadha Q. Ali +7 more
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A Double-Edged Sword: Extracellular Serine Proteases as Facilitators of Infection and Mediators of Immunity [PDF]
MoleculesSerine proteases are a class of enzymes that orchestrate an immune response. These proteases can be hijacked by viruses to facilitate entry and spread, while simultaneously supporting the innate immune system in neutralizing pathogens.
Alua Shagirova +4 more
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Serine Proteases in Rodent Hippocampus [PDF]
Journal of Biological Chemistry, 1998 Brain serine proteases are implicated in developmental processes, synaptic plasticity, and in disorders including Alzheimer's disease. The spectrum of the major enzymes expressed in brain has not been established previously. We now present a systematic study of the serine proteases expressed in adult rat and mouse hippocampus.
Davies, Ben J. +4 more
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Genome-wide survey of prokaryotic serine proteases: Analysis of distribution and domain architectures of five serine protease families in prokaryotes [PDF]
BMC Genomics, 2008 Background Serine proteases are one of the most abundant groups of proteolytic enzymes found in all the kingdoms of life. While studies have established significant roles for many prokaryotic serine proteases in several physiological processes, such as ...
Tripathi Lokesh P, Sowdhamini R
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Serine proteases, their inhibitors and allergy [PDF]
Allergy: European Journal of Allergy and Clinical Immunology, 2006 This paper reviews four serine protease inhibitors and three protease gene defects that are associated with allergic conditions, suggesting an important role for these genes and their products in the development of allergy. Serine protease inhibitors may have a therapeutic potential in the treatment of allergy.
Smith, P K, Harper, J I
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Cross genome comparisons of serine proteases in Arabidopsis and rice [PDF]
BMC Genomics, 2006 Background Serine proteases are one of the largest groups of proteolytic enzymes found across all kingdoms of life and are associated with several essential physiological pathways.
Sowdhamini R, Tripathi Lokesh P
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Serine proteases and metalloproteases are highly increased in irritable bowel syndrome Tunisian patients [PDF]
Scientific Reports, 2023 Serine proteases are involved in many biological processes and are associated with irritable bowel syndrome (IBS) pathology. An increase in serine protease activity has been widely reported in IBS patients.
Souha Soussou +10 more
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