Results 31 to 40 of about 226,366 (284)

Functional analysis of a missense mutation in the serine protease inhibitor SPINT2 associated with congenital sodium diarrhea. [PDF]

PLoS ONE, 2014
Membrane-bound serine proteases play important roles in different biological processes. Their regulation by endogenous inhibitors is poorly understood.
Nicolas Faller, Ivan Gautschi, Laurent Schild   +2 more
doaj   +1 more source

Serine protease CrKP43 interacts with MAPK and regulates fungal development and mycoparasitism in Clonostachys chloroleuca

Microbiology Spectrum, 2023
Serine proteases are a group of important hydrolytic enzymes that play vital roles in various cellular processes in fungi. In this study, the S8 serine protease-encoding gene CrKP43 was identified in the highly efficient Clonostachys chloroleuca 67–1 ...
Binna Lv, Xue Zhao, Yan Guo, Shidong Li, Manhong Sun   +4 more
doaj   +1 more source

tPA promotes ADAMTS-4-induced CSPG degradation, thereby enhancing neuroplasticity following spinal cord injury

Neurobiology of Disease, 2014
Although tissue plasminogen activator (tPA) is known to promote neuronal remodeling in the CNS, no mechanism of how this plastic function takes place has been reported so far.
Sighild Lemarchant, Mathilde Pruvost, Marie Hébert, Maxime Gauberti, Yannick Hommet, Aurélien Briens, Eric Maubert, Yatma Gueye, François Féron, Didier Petite, Marcel Mersel, Jean-Claude do Rego, Hubert Vaudry, Jari Koistinaho, Carine Ali, Véronique Agin, Evelyne Emery, Denis Vivien   +17 more
doaj   +1 more source

Activity-Based Probes to Utilize the Proteolytic Activity of Cathepsin G in Biological Samples

Frontiers in Chemistry, 2021
Neutrophils, migrating to the site of infection, are able to release serine proteases after being activated. These serine proteases comprise cathepsin G (CatG), neutrophil elastase protease 3 (PR3), and neutrophil serine protease 4 (NSP4). A disadvantage
Timo Burster, Fabian Gärtner, Uwe Knippschild, Anuar Zhanapiya   +3 more
doaj   +1 more source

A comprehensive nomenclature for serine proteases with homology to tissue kallikreins [PDF]

, 2006
The human kallikrein locus on chromosome 19q13.3-13.4 contains kallikrein 1 - the tissue kallikrein - and 14 related serine proteases. Recent investigations into their function and evolution have indicated that the present nomenclature for these proteins
Scorilas, Andreas, Malm, Johan,, Talieri, M, Courty, Yves, Ulf-Håkan Stenman, Lundwall, Åke,, Yousef, George M, Georgia Sotiropoulou, Lois J. Maltais, Talieri, Maroulio, Olsson, A Yvonne, Yousef, George, Talieri, M., Malm, Johan, Carsten Stephan, Stephan, Carsten, Blaber, M., Liija, H., Malm, J., Fritz, Hans, Petraki, C, Scorilas, A, Diamandis, EP, Blaber, Michael, Clements, Judith A, Lundwall, A., Lilja, Hans, Andreas Scorilas, Scorilas, A., Olsson, A. Yvonne, Hans Fritz, Judith A. Clements, Clements, JA, Fritz, H., Lundwall, Åke, Constantina Petraki, Maltais, Lois J, Sotiropoulou, Georgia, Clements, J A, Clements, Judith, Lilja, H, Lund University., Blaber, M, Olsson, AY, Vimla Band, A. Yvonne Olsson, Lundwall, A, Band, Vimla, Maroulio Talieri, Stephan, C., Sotiropoulou, G, Lilja, Hans,, Yousef, G M, Petraki, Constantina, Courty, Y, Fritz, H, Sotiropoulou, G., Courty, Y., Eleftherios P. Diamandis, Maltais, LJ, Åke Lundwall, Michael Blaber, Yousef, GM, Diamandis, Eleftherios P, Hans Lilja, Stenman, Ulf-Hakan, Diamandis, E P, Maltais, L J, Stephan, C, Petraki, C., George M. Yousef, Stenman, UH, Malm, J, Band, V, Yves Courty, Olsson, A Y, Band, V., Maltais, Lois, Diamandis, Eleftherios, Johan Malm   +79 more
core   +1 more source

Induction of IDO1 and Kynurenine by Serine Proteases Subtilisin, Prostate Specific Antigen, CD26 and HtrA: A New Form of Immunosuppression?

Frontiers in Immunology, 2022
Several serine proteases have been linked to autoimmune disorders and tumour initiation although the mechanisms are not fully understood. Activation of the kynurenine pathway enzyme indoleamine-2,3-dioxygenase (IDO1) modulates cellular activity in the ...
Felix I. L. Clanchy, Felix I. L. Clanchy, Yi-Shu Huang, Joy Ogbechi, L. Gail Darlington, Richard O. Williams, Trevor W. Stone   +6 more
doaj   +1 more source

Malarial proteases and host cell egress: an 'emerging' cascade. [PDF]

, 2008
Malaria is a scourge of large swathes of the globe, stressing the need for a continuing effort to better understand the biology of its aetiological agent. Like all pathogens of the phylum Apicomplexa, the malaria parasite spends part of its life inside a
Blackman, Michael J
core   +1 more source

Purification and characterization of novel fibrinolytic proteases as potential antithrombotic agents from earthworm Perionyx excavatus [PDF]

, 2011
Six protease fractions, namely FI, FII, FIII-1, FIII-2, FIII-3 and FIV, were isolated from Perionyx excavatus earthworm biomass by acetone precipitation, followed by serial chromatography using anion exchange, hydrophobic interaction and size exclusion ...
Giang Duong, Tien Duy Ta, phan, T.T.B., Tram Phan, Tram Thi Bich Phan, Dung Nguyen, Broek, L.A.M., van den, Dung Thi Xuan Nguyen, Giang Thi Huong Duong, Tien Ta, van den Broek, L.A.M., Ta, T.D., Lambertus AM Van Den Broek, Nguyen, D.T.X.   +13 more
core   +1 more source

SPINK6 inhibits human airway serine proteases and restricts influenza virus activation

EMBO Molecular Medicine, 2021
SPINK6 was identified in human skin as a cellular inhibitor of serine proteases of the KLK family. Airway serine proteases are required to cleave hemagglutinin (HA) of influenza A viruses (IAVs) to initiate an infection in the human airway.
Dong Wang, Cun Li, Man Chun Chiu, Yifei Yu, Xiaojuan Liu, Xiaoyu Zhao, Jingjing Huang, Zhongshan Cheng, Shuofeng Yuan, Vincent Poon, Jian‐Piao Cai, Hin Chu, Jasper Fuk‐Woo Chan, Kelvin Kai‐Wang To, Kwok Yung Yuen, Jie Zhou   +15 more
doaj   +1 more source

Airway proteolytic control of pneumococcal competence.

PLoS Pathogens, 2023
Streptococcus pneumoniae is an opportunistic pathogen that colonizes the upper respiratory tract asymptomatically and, upon invasion, can lead to severe diseases including otitis media, sinusitis, meningitis, bacteremia, and pneumonia.
Haley Echlin, Amy Iverson, Ugo Sardo, Jason W Rosch   +3 more
doaj   +1 more source