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Staphylococcal SplA and SplB serine proteases target ubiquitin(-like) specific proteases [PDF]
AMB ExpressStaphylococcus aureus is a Gram-positive opportunistic pathogen that has colonized nearly 30% of the human population and can cause life-threatening infections. S. aureus exports a variety of virulence factors, such as a novel set of extracellular serine
Felix L. Glinka +13 more
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The Versatility of Serine Proteases from Brazilian Bothrops Venom: Their Roles in Snakebites and Drug Discovery [PDF]
BiomoleculesSerine proteases are multifunctional and versatile venom components found in viper snakes, including the Bothrops species, a widely distributed genus notorious for causing the highest number of snakebites across Latin America. These enzymes, representing
Marcela Romanazzi +12 more
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Exploring the Diversity and Function of Serine Proteases in Toxicofera Reptile Venoms: A Comprehensive Overview [PDF]
ToxinsToxicofera reptile venoms are composed of several toxins, including serine proteases. These proteases are glycosylated enzymes that affect the prey’s hemostatic system. Their actions extend across the coagulation cascade, the kallikrein–kinin system, and
Julia F. D. Vidal +7 more
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Airborne indoor allergen serine proteases and their contribution to sensitisation and activation of innate immunity in allergic airway disease [PDF]
European Respiratory ReviewCommon airborne allergens (pollen, animal dander and those from fungi and insects) are the main triggers of type I allergic disorder in the respiratory system and are associated with allergic rhinitis, allergic asthma, as well as immunoglobulin E (IgE ...
Xuan Ouyang +3 more
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Design, synthesis, and evaluation of Bothrops venom serine protease peptidic inhibitors [PDF]
Journal of Venomous Animals and Toxins including Tropical Diseases, 2021 Background: In Central and South America, snakebite envenomation is mainly caused by Bothrops spp. snakes, whose venoms feature significant biochemical richness, including serine proteases.
Gloria Maria da Silva +8 more
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REVIEW OF SERINE PROTEASE INHIBITORS: DEVELOPMENT AND APPLICATIONS [PDF]
Bulletin of Pharmaceutical Sciences. Assiut University, 2023 A class of enzymes known as proteases is responsible for catalyzing the breakdown of covalent peptide bonds. Proteases account for almost 2% of the genes in humans, infectious organisms, and other forms of life.
Mai Ramadan
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Frontiers in Cellular and Infection Microbiology, 2021 The pathobiont Streptococcus pneumoniae causes life-threatening diseases, including pneumonia, sepsis, meningitis, or non-invasive infections such as otitis media.
Murtadha Q. Ali +4 more
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Regulation of Neutrophil Serine Proteases by Intracellular Serpins [PDF]
, 2015 Neutrophil granules contain serine proteases that are central components of the antimicrobial weapons of the innate immune system. Neutrophil proteases also contribute to the amplification and resolution of inflammatory responses through defined ...
Benarafa, Charaf
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Peptidyl Activity-Based Probes for Imaging Serine Proteases
Frontiers in Chemistry, 2021 Proteases catalyze the hydrolysis of peptide bonds. Products of this breakdown mediate signaling in an enormous number of biological processes. Serine proteases constitute the most numerous group of proteases, accounting for 40%, and they are prevalent ...
Paulina Kasperkiewicz
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European Journal of Entomology, 2023 Rhyzopertha dominica is a pest that uses trypsin-like serine protease enzymes to hydrolyse the proteins in the cereal grains on which it feeds. The present study reveals for the first time that that there are both glycosylated and non-glycosylated serine
Fernanda S. ZAVALA-IBARRA +9 more
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