Results 261 to 270 of about 103,544 (298)
Some of the next articles are maybe not open access.
Novel Serine Protease Inhibitors
Pharmaceutical Patent Analyst, 2012The pursuit of serine protease inhibitors as anticoagulants and anti-hepatitis C virus drugs continues to be an active area of research. Compounds such as P1-P3 macrocyclic peptides and linear peptides have been registered as potent hepatitis C virus protease inhibitors and compounds such as phenylglycinamide derivatives, substituted biaryls ...
Anilkumar R, Kore +1 more
openaire +2 more sources
Serine protease inhibitors (serpins)
Trends in Cardiovascular Medicine, 1991Inhibition of serine proteases by serpins (serpin: serine protease inhibitor) is a key mechanism for the control of proteolysis in thrombosis, shock, and inflammation. The various members of the serpin gene superfamily (α(1)-antitrypsin, ovalbumin, C1-inhibitor, antithrombin III, α(2)-antiplasmin, type-1 plasminogen-activator inhibitor, and so forth ...
M, Schapira, P A, Patston
openaire +2 more sources
The modular serine proteases of the complement cascade
Current Opinion in Structural Biology, 2012Modular serine proteases are central to the complement cascade of the mammalian humoral immune system. These proteases form protein complexes through multi-domain interactions to achieve their proteolytic activity. We review the structural insights into complement initiation by auto-activation of the hetero-tetrameric proteases of the large danger ...
FORNERIS, FEDERICO, Jin Wu, Piet Gros
openaire +5 more sources
Coumarin and Isocoumarin as Serine Protease Inhibitors
Current Pharmaceutical Design, 2004Serine proteases are attractive targets for the design of enzyme inhibitors since they are involved in the etiology of several diseases. Within the class of serine proteases, HLE is one of the most destructive enzymes in the body. It is implicated in the promotion or exacerbation of a number of diseases including pancreatitis, acute respiratory ...
Pochet, L. +2 more
openaire +2 more sources
Neutral serine proteases of neutrophils
Immunological Reviews, 2016SummaryNeutrophil serine proteases (NSPs) exercise tissue‐degrading and microbial‐killing effects. The spectrum of NSP‐mediated functions grows continuously, not least because of methodological progress. Sensitive and specific FRET substrates were developed to study the proteolytic activity of each NSP member. Advanced biochemical methods are beginning
openaire +2 more sources
Serine Protease Mechanism and Specificity
ChemInform, 2002AbstractFor Abstract see ChemInform Abstract in Full Text.
openaire +2 more sources
Serine proteases and serine protease inhibitors in breast cancer cell pathophysiology
2010Hemostasis and fibrinolysis are mediated by serine proteases and regulated by serine protease inhibitors, or serpins. There is a growing body of evidence that a few of these serine proteases and serpins have direct effects on cancer pathophysiology.
openaire +1 more source