Results 171 to 180 of about 95,130 (254)

Entamoeba histolytica-induced NETs are highly cytotoxic on hepatic and colonic cells due to serine proteases and myeloperoxidase activities. [PDF]

Front Immunol
Jorge-Rosas F, Díaz-Godínez C, García-Aguirre S, Martínez-Calvillo S, Carrero JC.   +4 more
europepmc   +1 more source

Human Leukocyte Elastase Triggered Nanoparticles for Targeted Antimicrobial Delivery and Oral Microbial Modulation

Advanced NanoBiomed Research, EarlyView.
This study explores enzyme‐responsive nanoparticles for targeted antimicrobial release in inflamed oral environments. Nanoparticles formed by complexing peptides and chlorhexidine respond to human leukocyte elastase and release chlorhexidine selectively. P7 (ECAAPVCE)‐based formulations show optimal properties and stability, with antimicrobial activity
Mohammed A. Hadis, Ignacio Insua, Farah N. S. Raja, Álvaro Vila, William M. Palin, Michael R. Milward, Paul R. Cooper, Sarah A. Kuehne, Owen Addison, Paco Fernandez‐Trillo   +9 more
wiley   +1 more source

Isosteric Engineering of Enzymes: Overcoming Activity–Stability Trade‐Offs by Site‐Selective CH → N Substitutions

Angewandte Chemie, EarlyView.
Coupling biosynthetic noncanonical amino acid production with genetic code expansion enables site‐specific incorporation of azatryptophans into PET‐degrading enzymes (PETases). By isosteric single‐atom editing of a conserved tryptophan, AzaPETases break the activity–stability trade‐off, delivering higher catalytic efficiency at elevated temperature and
Elwy H. Abdelkader, Haocheng Qianzhu, Gottfried Otting, Thomas Huber   +3 more
wiley   +2 more sources

The early communication stages between serine proteases and enterovirus capsids in the race for viral disintegration. [PDF]

Commun Biol
Corre MH, Rey B, David SC, Torii S, Chiappe D, Kohn T.   +5 more
europepmc   +1 more source

Neutrophil-derived serine proteases induce FOXA2-mediated autophagy dysfunction and exacerbate colitis-associated carcinogenesis via protease activated receptor 2. [PDF]

Autophagy
Yuan J, Ma J, Zhang F, Wang T, Jian X, Wang B, Li W, Zhang X, Cao Y, Yang H, Ma Y, Wang H.   +11 more
europepmc   +1 more source

Serine Protease HTRA1 [PDF]

, 2020
openaire   +1 more source

New advances in understanding inhibition of myeloperoxidase and neutrophil serine proteases by two families of staphylococcal innate immune evasion proteins. [PDF]

Arch Biochem Biophys
Herdendorf TJ, Mishra N, Fatehi S, Gido CD, Prakash O, Geisbrecht BV.   +5 more
europepmc   +1 more source

The early communication stages between serine proteases and enterovirus capsids in the race for viral disintegration

, 2023
Corre M, Rey B, David SC, Torii S, Chiappe D, Kohn T.   +5 more
europepmc   +1 more source

Peptidthioester und Peptidtriazolderivate durch Duale Modifikation von Peptidthiosulfonaten auf dem Harz

Angewandte Chemie, EarlyView.
Es wird eine Strategie zur dualen Modifikation von Peptiden auf der Festphase vorgestellt, die die S‐Alkinylierung von Peptidthiosulfonaten und eine regioselektive, iridiumkatalysierte Azid‐Thioalkin‐Zykloaddition umfasst. Dieses Verfahren ermöglicht zuverlässig den Zugang zu Peptiden mit komplexen, nicht‐kanonischen Modifikationen und ist mit ...
Marius Werner, Agnes Bergmann, Chenxi Liu, Mira Behnam, Christian Klein, Franziska Thomas   +5 more
wiley   +1 more source

Structural Catalytic Core in Subtilisin-like Proteins and Its Comparison to Trypsin-like Serine Proteases and Alpha/Beta-Hydrolases. [PDF]

Int J Mol Sci
Denesyuk AI, Denessiouk K, Johnson MS, Uversky VN.   +3 more
europepmc   +1 more source