Results 171 to 180 of about 64,650 (212)

USP7 deubiquitinase stabilizes FAN1 to support DNA crosslink repair and suppress CAG repeat expansion. [PDF]

Nat Commun
Collotta G, Gatti M, Ungureanu IM, van Ackeren V, Rannou E, Vivalda F, Gomez Vieito D, Fishwick KM, von Aesch C, Porro A, Ungerleider K, Heidari A, Guérois R, Harding RJ, Bischof S, Balmus G, Sartori AA.   +16 more
europepmc   +1 more source

Efficacy of Hepatic Artery Infusion Chemotherapy Combined With Regorafenib and Sintilimab Versus Regorafenib Alone in MSS/pMMR Colorectal Cancer Liver Metastases After Second‐Line Treatment Failure

Cancer Medicine, Volume 15, Issue 5, May 2026.
ABSTRACT Background Microsatellite stable/proficient mismatch repair (MSS/pMMR) colorectal cancer liver metastases (CRCLM) have limited treatment options after failure of second‐line systemic therapies. Hepatic artery infusion chemotherapy (HAIC) combined with targeted therapy and immunotherapy may offer improved outcomes.
Ran You, Qingyu Xu, Lixing Wang, Bin Leng, Chendong Wang, Zeyu Yu, Ya Lu, Lingfeng Diao, Yi Lu, Guowen Yin   +9 more
wiley   +1 more source

Lymphotropic Virotherapy Induces DC and High Endothelial Venule Inflammation, Promoting the Antitumor Efficacy of Intratumor Virus Administration. [PDF]

Cancer Immunol Res
Ludwig AL, McKay ZP, Carter GP, Katz MA, Howell G, Jain V, Arvai S, Dittmer DP, Bigner DD, Ashley DM, Shoaf ML, Desjardins A, Gregory SG, Brown MC, Gromeier M.   +14 more
europepmc   +1 more source

Novel Insights Into the Association Between Parkinson's Disease and Constipation: Role of SHMT2 as a Promising Biomarker

CNS Neuroscience &Therapeutics, Volume 32, Issue 5, May 2026.
This study integrated bioinformatics analysis, cellular models, and PD/constipation mouse models to identify SHMT2 as a key shared biomarker linking Parkinson's disease and constipation. SHMT2 upregulation was validated in dopaminergic neurons and the enteric nervous system, highlighting its potential role in gut–brain axis dysfunction.
Jiehua Su, Kaixun Huang, Xiuna Jing, Xiaohuan Liu, Cheng Wen, Rulin Geng, Zhuoying Lai, Zhijia Ruan, Yiqiang Zhan, Danyu Lin, Enxiang Tao   +10 more
wiley   +1 more source

Chromatin regulators <i>TOP2A</i> and <i>PPARGC1A</i> stratify prostate cancer risk and reveal <i>TOP2A</i>-driven progression via PI3K/AKT pathway. [PDF]

Chin J Cancer Res
Wang Z, Wang J, Chen S, Wu R, Tuo Z, Ye L, Yoo KH, Li D, Jin X, Xiong W, Feng D.   +10 more
europepmc   +1 more source

STK25 inhibits cancer‐associated fibroblast activation to overcome cetuximab resistance in colorectal cancer

Clinical and Translational Medicine, Volume 16, Issue 5, May 2026.
• STK25 deficiency enhanced CAF‐mediated CRC growth via the NF‐κB/AREG/EGFR axis. • STK25 overexpression or AREG antibody overcame CAF‐mediated cetuximab resistance. • CRC patients with high STK25 and low CAFs marker levels might benefit from cetuximab treatment.
Yifan Hou, Jiangbo Chen, Hao Hao, Tongkun Song, Lin Song, Pu Xing, Kai Weng, Yumeng Ran, Xinying Yang, Xiaowen Qiao, Jie Chen, Ruibin Yao, Hong Yang, Lei Chen, Jiabo Di, Kai Xu, Xiangqian Su, Beihai Jiang   +17 more
wiley   +1 more source

Serine protease-driven entry and S2 ' cleavage flexibility of feline coronavirus during feline enterocyte infections. [PDF]

PLoS Pathog
Chen B, Vanden Buijs L, Vanderheijden N, Desmarets L, Van Cleemput J, Nauwynck HJ.   +5 more
europepmc   +1 more source

Adapted Live SARS‐CoV‐2 Vaccine Elicits Rapid Mucosal Immunity, Protects From Disease, and Reduces Shedding of XBB.1.5

European Journal of Immunology, Volume 56, Issue 5, May 2026.
An attenuated live vaccine (OTS‐300) expressing the XBB.1.5 Spike provided rapid and complete protection against homologous challenge in the hamster model, accompanied by fast systemic and mucosal antibody responses and markedly reduced transmission compared with XBB.1.5 mRNA vaccination.
Jana Kochmann, Tobias Britzke, Nico Joël Halwe, Lorenz Ulrich, Angele Breithaupt, G. Tuba Barut, Nadine Ebert, Bettina Salome Trüeb, Volker Thiel, Anca Dorhoi, Martin Beer, Donata Hoffmann, Björn Corleis, Jacob Schön   +13 more
wiley   +1 more source

Fluid biomarkers for neurodegenerative diseases: a comprehensive update. [PDF]

Alzheimers Res Ther
Valletta M, Briel N, Yuksekel I, Barboure M, Coward A, De Houwer JFH, Fawad A, González-Mayoral A, Iaccarino G, Martínez-Dubarbie F, Moukaled S, Andreasson U, Gobom J, Brinkmalm A, Tijms B, Zetterberg H, Blennow K, Suárez-Calvet M, Schöll M, Paterson RW, Montoliu-Gaya L, Sogorb-Esteve A.   +21 more
europepmc   +1 more source

NEK7 phosphorylation of cortactin modulates the migratory capacity of cells expressing EML4-ALK V3. [PDF]

Sci Rep
Richardson EL, Knebel A, Straatman KR, Gourlay R, Lamont D, Hardy T, Turnbull RE, Robinson SW, O'Regan L, Bayliss R, Fry AM.   +10 more
europepmc   +1 more source