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Serine Repeat Antigen（SERA5）Is Predominantly Expressed among the SERA Multigene Family of Plasmodium falciparum, and the Acquired Antibody Titers Correlate with Serum Inhibition of the Parasite Growth

Serine Repeat Antigen（SERA5）Is Predominantly Expressed among the SERA Multigene Family of Plasmodium falciparum, and the Acquired Antibody Titers Correlate with Serum Inhibition of the Parasite Growth
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Plasmodium falciparum serine repeat antigen 5 (SE36) as a malaria vaccine candidate

Vaccine, 2011
A devastating disease spread by mosquitoes with high-efficiency, malaria imposes an enormous burden for which no licensed vaccine currently exists. Although the genome complexity of the parasite has made vaccine development tenuous, an effective malaria vaccine would be a valuable tool for control, elimination and eventual eradication.
Nirianne Marie Palacpac, Nobuko Arisue, Takahiro Tougan   +2 more
exaly   +3 more sources

Serine repeat antigen peptides which bind specifically to red blood cells

Parasitology International, 2000
It has been reported that serine repeat antigen (SERA) binds directly to human erythrocyte membranes, inside-out vesicles and intact mouse erythrocytes. Similarly, mAbs specific against SERA are effective in blocking red blood cell (RBC) invasion by P. falciparum merozoites.
Mauricio Urquiza, Magnolia Vanegas, Manuel Elkin Me Patarroyo Murillo   +2 more
exaly   +3 more sources

Plasmodium falciparum serine-repeat antigen (SERA) forms a homodimer through disulfide bond

Parasitology International, 2005
Plasmodium falciparum serine-repeat antigen (SERA) is one potential blood-stage vaccine candidate and is expressed as a protomer that is subsequently processed into four fragments (P47, P50, P6, and P17). Although recent evidence shows that P50 exhibits chymotrypsin-like protease activity, the function of SERA is still largely unknown.
Toshihiro Horii
exaly   +3 more sources

Identification and cloning of a locus of serine repeat antigen (sera)-related genes from Plasmodium vivax

Molecular and Biochemical Parasitology, 1996
Polymerase chain reaction (PCR) primers based on the cysteine proteinase-like active site regions of the Plasmodium falciparum serine repeat antigen (SERA) were used to identify related sequences within the genome of P. vivax. Molecular cloning and sequence analysis of approximately 25 kb of P. vivax genomic DNA revealed a cluster of five repeated SERA-
M C, Kiefer, K A, Crawford, L J, Boley, K E, Landsberg, H L, Gibson, D C, Kaslow, P J, Barr   +6 more
exaly   +3 more sources

Characterization of proteases involved in the processing of Plasmodium falciparum serine repeat antigen (SERA)

Molecular and Biochemical Parasitology, 2002
The Plasmodium falciparum serine repeat antigen (SERA), a malaria vaccine candidate, is processed into several fragments (P73, P47, P56, P50, and P18) at the late schizont stage prior to schizont rupture in the erythrocytic cycle of the parasite. We have established an in vitro cell-free system using a baculovirus-expressed recombinant SERA (bvSERA ...
Hiroyuki Matsuoka, Toshihiro Horii
exaly   +3 more sources

Complement-mediated killing of Plasmodium falciparum erythrocytic schizont with antibodies to the recombinant serine repeat antigen (SERA)

Vaccine, 1998
Mouse antiserum against the recombinant N-terminal domain (SE47') of serine repeat antigen (SERA) of Plasmodium falciparum inhibited the in vitro proliferation of the parasite. We purified the immunoglobulin G from mice immunized with SE47' and with Freund's or aluminum hydroxide gel, or without adjuvants. Antiserum prepared with aluminum hydroxide gel
Toshihiro Horii
exaly   +3 more sources

Differential localization of processed fragments of Plasmodium falciparum serine repeat antigen and further processing of its N-terminal 47 kDa fragment

Parasitology International, 2002
The serine repeat antigen (SERA) of Plasmodium falciparum is a blood stage malaria vaccine candidate. It has been shown that 120 kDa SERA was proteolytically processed into N-terminal 47 kDa fragment (P47), central 56 kDa fragment (P56) that was further converted to 50 kDa (P50), and C-terminal 18 kDa fragment (P18).
David J Bzik, Toshihiro Horii, Barbara A Fox   +2 more
exaly   +3 more sources

Sequence diversity in the amino-terminal region of the malaria-vaccine candidate serine repeat antigen in natural Plasmodium falciparum populations

Parasitology International, 2003
The amino-terminal region of the serine repeat antigen (SERA) of Plasmodium falciparum is a major malaria-vaccine candidate. Variation in this molecule is essentially dimorphic and alleles may be grouped into the types FCR3, K1 and Honduras1. The Honduras1-type is thought to be the product of homologous recombination between FCR3 and K1 alleles.
Marcelo U Ferreira, Toshihiro Horii
exaly   +3 more sources

DNA immunization with Plasmodium falciparum serine repeat antigen: regulation of humoral immune response by coinoculation of cytokine expression plasmid

Parasitology International, 1999
We immunized mice with plasmid expressing the 47-kDa amino-terminal domain of the Plasmodium falciparum serine repeat antigen (SERA) using gene gun and investigated humoral immune response to SERA antigen. Significant SERA-specific IgG was observed in BALB/c mice after immunization three times with SERA expression plasmid.
Toshihiro Horii, Yoko Nakano, Yoichi Maekawa   +2 more
exaly   +3 more sources