Results 11 to 20 of about 64,650 (212)

Safety and immunogenicity of BK-SE36/CpG malaria vaccine in healthy Burkinabe adults and children: a phase 1b randomised, controlled, double-blinded, age de-escalation trial

Frontiers in Immunology, 2023
BackgroundBK-SE36/CpG is a recombinant blood-stage malaria vaccine candidate based on the N-terminal Plasmodium falciparum serine repeat antigen5 (SE36), adsorbed to aluminium hydroxide gel and reconstituted, prior to administration, with synthetic ...
Alphonse Ouédraogo, Edith Christiane Bougouma, Nirianne Marie Q. Palacpac, Sophie Houard, Issa Nebie, Jean Sawadogo, Gloria D. Berges, Issiaka Soulama, Amidou Diarra, Denise Hien, Amidou Z. Ouedraogo, Amadou T. Konaté, Seni Kouanda, Akira Myoui, Sachiko Ezoe, Sachiko Ezoe, Ken J. Ishii, Ken J. Ishii, Ken J. Ishii, Takanobu Sato, Flavia D’Alessio, Odile Leroy, Alfred B. Tiono, Simon Cousens, Toshihiro Horii, Sodiomon B. Sirima   +25 more
doaj   +1 more source

Plasmodial serine repeat antigen homologues with properties of schizont cysteine proteases [PDF]

Molecular and Biochemical Parasitology, 1998
Proteases appear to be required for critical events in the erythrocytic life cycle of malaria parasites, including the rupture of erythrocytes by mature schizonts and the subsequent invasion of erythrocytes by daughter merozoites [1,2]. This conclusion is supported by studies showing that parasite rupture and invasion of erythrocytes are inhibited by ...
D O, Gor, A C, Li, M F, Wiser, P J, Rosenthal   +3 more
openaire   +2 more sources

Plasmodium falciparum infection coinciding with the malaria vaccine candidate BK-SE36 administration interferes with the immune responses in Burkinabe children

Frontiers in Immunology, 2023
BackgroundA vaccine targeting the erythrocyte stages of Plasmodium falciparum could play a role in preventing clinical disease. BK-SE36 is a promising malaria vaccine candidate that has shown a good safety profile and immunological responses during field
Alfred B. Tiono, Alfred B. Tiono, Nirianne Marie Q. Palacpac, Edith Christiane Bougouma, Issa Nebie, Alphonse Ouédraogo, Sophie Houard, Nobuko Arisue, Flavia D’Alessio, Toshihiro Horii, Sodiomon B. Sirima   +10 more
doaj   +1 more source

Protective epitopes of the Plasmodium falciparum SERA5 malaria vaccine reside in intrinsically unstructured N-terminal repetitive sequences. [PDF]

PLoS ONE, 2014
The malaria vaccine candidate antigen, SE36, is based on the N-terminal 47 kDa domain of Plasmodium falciparum serine repeat antigen 5 (SERA5). In epidemiological studies, we have previously shown the inhibitory effects of SE36 specific antibodies on in ...
Masanori Yagi, Gilles Bang, Takahiro Tougan, Nirianne M Q Palacpac, Nobuko Arisue, Taiki Aoshi, Yoshitsugu Matsumoto, Ken J Ishii, Thomas G Egwang, Pierre Druilhe, Toshihiro Horii   +10 more
doaj   +1 more source

Safety and immunogenicity of BK-SE36 in a blinded, randomized, controlled, age de-escalating phase Ib clinical trial in Burkinabe children

Frontiers in Immunology, 2022
BackgroundA blood-stage vaccine targeting the erythrocytic-stages of the malaria parasite Plasmodium falciparum could play a role to protect against clinical disease. Antibodies against the P.
Edith Christiane Bougouma, Edith Christiane Bougouma, Nirianne Marie Q. Palacpac, Alfred B. Tiono, Alfred B. Tiono, Issa Nebie, Issa Nebie, Alphonse Ouédraogo, Alphonse Ouédraogo, Sophie Houard, Masanori Yagi, Sam Aboubacar Coulibaly, Amidou Diarra, Amidou Diarra, Takahiro Tougan, Amidou Z. Ouedraogo, Amidou Z. Ouedraogo, Issiaka Soulama, Nobuko Arisue, Jean Baptiste Yaro, Flavia D’Alessio, Odile Leroy, Simon Cousens, Toshihiro Horii, Sodiomon B. Sirima, Sodiomon B. Sirima   +25 more
doaj   +1 more source

Immunogenicity of the Plasmodium falciparum serine repeat antigen (p126) expressed by vaccinia virus [PDF]

Infection and Immunity, 1993
cDNA encoding the serine repeat antigen (SERA) (also called p126) of Plasmodium falciparum has been isolated from the FCR3 strain and inserted into a recombinant vaccinia virus designated vP870. Expression analysis of vP870-infected Vero cells by immunoprecipitation has demonstrated several intracellular forms of SERA and a single secreted SERA peptide.
J A, Tine, V, Conseil, P, Delplace, C, De Taisne, D, Camus, E, Paoletti   +5 more
openaire   +2 more sources

Characteristic features of the SERA multigene family in the malaria parasite

Parasites & Vectors, 2020
Serine repeat antigen (SERA) is conserved among species of the genus Plasmodium. Sera genes form a multigene family and are generally tandemly clustered on a single chromosome. Although all Plasmodium species encode multiple sera genes, the number varies
Nobuko Arisue, Nirianne M. Q. Palacpac, Takahiro Tougan, Toshihiro Horii   +3 more
doaj   +1 more source

A structural model for binding of the serine-rich repeat adhesin GspB to host carbohydrate receptors. [PDF]

PLoS Pathogens, 2011
GspB is a serine-rich repeat (SRR) adhesin of Streptococcus gordonii that mediates binding of this organism to human platelets via its interaction with sialyl-T antigen on the receptor GPIbα.
Tasia M Pyburn, Barbara A Bensing, Yan Q Xiong, Bruce J Melancon, Thomas M Tomasiak, Nicholas J Ward, Victoria Yankovskaya, Kevin M Oliver, Gary Cecchini, Gary A Sulikowski, Matthew J Tyska, Paul M Sullam, T M Iverson   +12 more
doaj   +1 more source

Antigen Discovery in Circulating Extracellular Vesicles From Plasmodium vivax Patients

Frontiers in Cellular and Infection Microbiology, 2022
Plasmodium vivax is the most widely distributed human malaria parasite with 7 million annual clinical cases and 2.5 billion people living under risk of infection.
Iris Aparici-Herraiz, Melisa Gualdrón-López, Carlos J. Castro-Cavadía, Jaime Carmona-Fonseca, María Fernanda Yasnot, Carmen Fernandez-Becerra, Carmen Fernandez-Becerra, Carmen Fernandez-Becerra, Hernando A. del Portillo, Hernando A. del Portillo, Hernando A. del Portillo   +10 more
doaj   +1 more source

Evidence for a Common Role for the Serine-Type Plasmodium falciparum Serine Repeat Antigen Proteases: Implications for Vaccine and Drug Design [PDF]

Infection and Immunity, 2007
ABSTRACT Serine repeat antigens (SERAs) are a family of secreted “cysteine-like” proteases of Plasmodium parasites. Several SERAs possess an atypical active-site serine residue in place of the canonical cysteine. The human malaria parasite Plasmodium falciparum possesses six “serine-
Joanne E, McCoubrie, Susanne K, Miller, Tobias, Sargeant, Robert T, Good, Anthony N, Hodder, Terence P, Speed, Tania F, de Koning-Ward, Brendan S, Crabb   +7 more
openaire   +2 more sources