Results 21 to 30 of about 64,650 (212)

Genetic polymorphism of the serine rich antigen N-terminal region in Plasmodium falciparum field isolates from Brazil

Memorias do Instituto Oswaldo Cruz, 2005
In this work we investigated the frequency of polymorphism in exon II of the gene encoding most of the amino-terminal region of the serine rich antigen (SERA) in Plasmodium falciparum field samples. The blood samples were colleted from P.
Evelyn Kety Pratt Riccio, Mariano Gustavo Zalis, Helena Cristina Balthazar Guedes, Dalma Maria Banic, José Maria de Souza, Wilson Alecrim, Daniel Camus, Cláudio Tadeu Daniel-Ribeiro, Maria de Fátima Ferreira-da-Cruz   +8 more
doaj   +1 more source

Protective immunity induced in squirrel monkeys with recombinant serine repeat antigen (SERA) of Plasmodium falciparum [PDF]

Parasitology International, 1997
Abstract We examined the immunogenicity and the protection by a recombinant blood stage antigen derived from the malaria parasite Plasmodium falciparum SERA (serine-repeat antigen) in squirrel monkeys ( Saimiro sciureus ). The monkeys were immunized with recombinant SE47' protein produced using a synthetic gene expressing amino acids 17-382 (SE47')
Kazutomo Suzue, Mamoru Ito, Yoshitsugu Matsumoto, Yoshikuni Tanioka, Toshihiro Horii   +4 more
openaire   +4 more sources

Phase 1b randomized trial and follow-up study in Uganda of the blood-stage malaria vaccine candidate BK-SE36. [PDF]

PLoS ONE, 2013
BACKGROUND: Up to now a malaria vaccine remains elusive. The Plasmodium falciparum serine repeat antigen-5 formulated with aluminum hydroxyl gel (BK-SE36) is a blood-stage malaria vaccine candidate that has undergone phase 1a trial in malaria-naive ...
Nirianne Marie Q Palacpac, Edward Ntege, Adoke Yeka, Betty Balikagala, Nahoko Suzuki, Hiroki Shirai, Masanori Yagi, Kazuya Ito, Wakaba Fukushima, Yoshio Hirota, Christopher Nsereko, Takuya Okada, Bernard N Kanoi, Kohhei Tetsutani, Nobuko Arisue, Sawako Itagaki, Takahiro Tougan, Ken J Ishii, Shigeharu Ueda, Thomas G Egwang, Toshihiro Horii   +20 more
doaj   +1 more source

Erythrocyte binding peptides: a story in the search for a malaria vaccine [PDF]

Exploration of Drug Science
Merozoite invasion of erythrocytes relies on molecular interactions between parasite and host proteins, making these proteins potential therapeutic targets.
Mauricio Urquiza-Martinez, Daniela Benavides-Rubio, Fanny Guzmán-Quimbayo   +2 more
doaj   +1 more source

Age-dependent carriage of alleles and haplotypes of Plasmodium falciparum sera5, eba-175, and csp in a region of intense malaria transmission in Uganda

Malaria Journal, 2020
Background The development of malaria vaccines is constrained by genetic polymorphisms exhibited by Plasmodium falciparum antigens. The project the age-dependent distribution of alleles or haplotypes of three P.
Constance Agwang, Joseph Erume, Brenda Okech, Joseph Olobo, Thomas G. Egwang   +4 more
doaj   +1 more source

A Plasmodium cysteine protease required for efficient transition from the liver infection stage.

PLoS Pathogens, 2020
The transitions between developmental stages are critical points in the Plasmodium life cycle. The development of Plasmodium in the livers of their mammalian hosts bridges malaria transmission and the onset of clinical symptoms elicited by red blood cell
Elyzana Dewi Putrianti, Anja Schmidt-Christensen, Volker Heussler, Kai Matuschewski, Alyssa Ingmundson   +4 more
doaj   +1 more source

Biofilm and planktonic pneumococci demonstrate disparate immunoreactivity to human convalescent sera

BMC Microbiology, 2011
Background Streptococcus pneumoniae (the pneumococcus) is the leading cause of otitis media, community-acquired pneumonia (CAP), sepsis, and meningitis. It is now evident that S.
Shivshankar Pooja, Lizcano Anel, Hurtgen Brady J, Sanchez Carlos J, Cole Garry T, Orihuela Carlos J   +5 more
doaj   +1 more source

The Serine Repeat Antigen (SERA) Gene Family Phylogeny in Plasmodium: The Impact of GC Content and Reconciliation of Gene and Species Trees [PDF]

Molecular Biology and Evolution, 2004
Plasmodium falciparum is the parasite responsible for the most acute form of malaria in humans. Recently, the serine repeat antigen (SERA) in P. falciparum has attracted attention as a potential vaccine and drug target, and it has been shown to be a member of a large gene family. To clarify the relationships among the numerous P.
Richard, Bourgon, Mauro, Delorenzi, Tobias, Sargeant, Anthony N, Hodder, Brendan S, Crabb, Terence P, Speed   +5 more
openaire   +2 more sources

Pooled-DNA sequencing identifies genomic regions of selection in Nigerian isolates of Plasmodium falciparum

Parasites & Vectors, 2017
Background The burden of falciparum malaria is especially high in sub-Saharan Africa. Differences in pressure from host immunity and antimalarial drugs lead to adaptive changes responsible for high level of genetic variations within and between the ...
Kolapo M. Oyebola, Emmanuel T. Idowu, Yetunde A. Olukosi, Taiwo S. Awolola, Alfred Amambua-Ngwa   +4 more
doaj   +1 more source

A unique serine-rich repeat protein (Srr-2) and novel surface antigen (ε) associated with a virulent lineage of serotype III Streptococcus agalactiae [PDF]

Microbiology, 2006
Group B streptococci (GBS) are pathogens of both neonates and adults, with serotype III strains in particular being associated with invasive disease and meningitis. In this study, a novel GBS surface antigen, ε, was found to be co-expressed with the previously reported δ antigen on an identical subset of serotype III GBS.
Kyle N, Seifert, Elisabeth E, Adderson, April A, Whiting, John F, Bohnsack, Paula J, Crowley, L Jeannine, Brady   +5 more
openaire   +2 more sources