Results 111 to 120 of about 59,691 (267)

Psilocybin in alcohol use disorder and comorbid depressive symptoms: Results from a feasibility randomized clinical trial

Addiction, EarlyView.
Abstract Background and Aims Psilocybin has emerged as a potential treatment for alcohol use disorder (AUD), but early efficacy data are inconsistent. Depression following alcohol detoxification significantly increases the risk of relapse. This pilot study aimed to evaluate the feasibility, acceptability, and preliminary efficacy of psilocybin‐assisted
Amandine Luquiens, Dahbia Belahda, Carine Graux, Noe Igounenc, Chris Serrand, Paul Rochefort, Thibault Mura, Felix Sergent   +7 more
wiley   +1 more source

Pharmacological Intensification Strategies in Highly Refractory Obsessive-Compulsive Disorder: Evidence Synthesis and a Tertiary-Care Case Series. [PDF]

J Clin Med
Pinzi M, Cuomo A, Carmellini P, Libri C, Rescalli MB, Pierini C, Santangelo A, Patrizio B, Fagiolini A.   +8 more
europepmc   +1 more source

The psychoactive effects of repeated ketamine infusions and their mechanistic role in the treatment of alcohol use disorder: Secondary analysis of a randomised controlled trial

Addiction, EarlyView.
Abstract Background and aims Ketamine assisted psychotherapy is a promising new treatment for alcohol use disorder (AUD). The psychoactive effects of repeated intravenous (IV) ketamine infusions in people with AUD and their mechanistic role in treating AUD are largely unknown.
Cassie Bloy, Ananya Sarma, Bethan Marsh, Lorna Hardy, Meryem Grabski, Merve Mollaahmetoglu, Joshua Shotton, Shamhethan Bhaskaran, Anne Lingford‐Hughes, H. Val Curran, Celia Morgan, Will Lawn   +11 more
wiley   +1 more source

Serotonin syndrome associated with concomitant tramadol and linezolid therapy: a case report and literature review. [PDF]

Front Pharmacol
Zhao H, Liu K, Zheng Y, Ni L.
europepmc   +1 more source

Comparative effectiveness, safety and acceptability of pharmacological and psychosocial interventions for the treatment of cannabis use disorder: A network meta‐analysis

Addiction, EarlyView.
Abstract Aim Our primary aim was to conduct a network meta‐analysis (NMA) for the effectiveness, safety and acceptability of all psychosocial interventions and all pharmacotherapies for cannabis use disorder (CUD). Methods We conducted a NMA of studies identified from two completed systematic reviews examining the effectiveness, safety and ...
Monika Halicka, Francesca Spiga, Tom P. Freeman, Suzanne Nielsen, Jelena Savović, Julian P. T. Higgins, Deborah M. Caldwell   +6 more
wiley   +1 more source

Sex-dependent serotonergic signaling across development: molecular mechanisms shaping vulnerability to neurodevelopmental and mental disorders. [PDF]

Front Pharmacol
Palacios-Avendaño N, Rojas PS, Alarcón-Mardones M, Fiedler JL.   +3 more
europepmc   +1 more source

Efficacy and safety of pharmacological interventions for the treatment of cocaine use disorder: A systematic review and network meta‐analysis

Addiction, EarlyView.
Abstract Background and aims Cocaine use disorder (CUD) is an increasingly widespread concern worldwide. Various pharmacological treatments have been investigated for CUD, but their efficacy remains unclear, and none have been licensed for treatment.
Craig Paterson, Thomas Parkhouse, Chloe Burke, Monika Halicka, Jennifer C. Palmer, Hend Gabr, Rebecca Wilson, Katie E. Webster, Francesca Spiga, Sarah Dawson, Deborah M. Caldwell, Jennifer Scott, Julian P. T. Higgins, Jelena Savović   +13 more
wiley   +1 more source

Isothiocyanate-Rich Essential Oil of <i>Morisonia flexuosa</i> L. Exhibits Anxiolytic-like Effects That May Involve Serotonergic Pathways in Zebrafish. [PDF]

Plants (Basel)
Rodrigues FFG, Carvalho NKG, Souza GGO, Santos HSD, de Menezes IRA, Barros Alves AM, Menezes JESA, Rodrigues FFG, Costa JGMD.   +8 more
europepmc   +1 more source

Time‐Resolved Multi‐Omics Identify Biomarkers of Immediate Reactions to mRNA Vaccination

Allergy, EarlyView.
We compared early vaccine‐induced immune and metabolic signatures and downstream immunity after second and booster BNT162b2 doses in participants with sARs, ISSRs, or no reactions. Neutrophil mobilization, antiviral programs, and robust anti‐S‐antibody responses occurred across reaction groups.
Ana Olivera, Benjamin Schwarz, Brittany Dulek, Ian S. LaCroix, Min Li, Lindsay Chatman, Muhammad B. Khalid, Ellen Zektser, Karen Laky, Stella Hartono, Eric Bohrnsen, Cole D. Kimzey, Eric Chu, Roa Harb, Pamela A. Frischmeyer‐Guerrerio   +14 more
wiley   +1 more source

A Serotoninomic Framework for Reproductive and Integrative Toxicology: Molecular, Neurochemical, and Behavioural Perspectives on Permethrin Exposure. [PDF]

Toxics
Jiménez-Trejo F, Carmona-Aparicio L, Coballase-Urrutia E, Jiménez-García KL, Arriaga-Canon C, Herrera LA.   +5 more
europepmc   +1 more source