Results 141 to 150 of about 59,691 (267)
Gut microbiota as a novel therapeutic target for eating disorders and obesity
British Journal of Pharmacology, EarlyView.The graphical abstract highlights the bidirectional interaction between the gut microbiota and central homeostatic and hedonic mechanisms regulating food intake, which contributes to overweight and obesity. It also illustrates emerging microbiota‐based biomarkers and therapeutic strategies (including prebiotics, probiotics, postbiotics, synbiotics and ...
Solveiga Samulėnaitė +5 more
wiley +1 more source
Activation of 5-HT1A autoreceptors causes actin depolymerization in <i>Drosophila</i> serotonergic neurons. [PDF]
MicroPubl BiolKinser A, Rhodes JK, Roossien DH.
europepmc +1 more source
British Journal of Pharmacology, EarlyView.Serotonin differentially modulates layer 5 mPFC microcircuits through cell type‐specific pre‐ and postsynaptic receptor pathways. Presynaptic 5‐HT1BRs suppress glutamate and GABA release, whereas presynaptic and postsynaptic 5‐HT3ARs enhance fast‐spiking interneuron activity, whilst distinct pyramidal neuron subtypes exhibit divergent 5‐HT1AR‐ and 5 ...
Ramya Rama +4 more
wiley +1 more source
Neuropsychiatric-pharmacologic synergy: interaction between psychiatric polypharmacy and cancer treatment-related neurotoxicity. [PDF]
Oxf Med Case ReportsWoytowitz SP, Manchee C.
europepmc +1 more source
Muscarinic agonists for schizophrenia: Bridging preclinical evidence and clinical enthusiasm
British Journal of Pharmacology, EarlyView.Abstract Antipsychotic drugs targeting dopamine receptors have been used to treat schizophrenia for decades, primarily alleviating positive symptoms such as hallucinations and delusions. However, they provide limited benefit for cognitive and negative symptoms—major contributors to poor outcomes—and are frequently associated with significant side ...
Brian J. Morris, Judith A. Pratt
wiley +1 more source
Editorial: Responses to chronic stress in vertebrate animals: from molecules to behavior. [PDF]
Front Endocrinol (Lausanne)Samaras A, Raftogianni A, Gorissen M.
europepmc +1 more source
Current Approaches to Support Patients to Withdraw From Image and Performance Enhancing Drugs
Clinical Endocrinology, EarlyView.ABSTRACT Image and performance‐enhancing drugs (IPEDs) include agents such as androgens, growth hormone, and erythropoietin, which are used to enhance appearance and physical performance. Androgens, also known as anabolic‐androgenic steroids (AAS), are the most used IPEDs worldwide.
Elizabeth Hyams +3 more
wiley +1 more source
The FEBS Journal, EarlyView.We investigated the potential of iloperidone as an activator of Sigma‐1 receptor (S1R) neuroprotective function in juvenile Huntington's disease (jHD). We tested iloperidone on cortical neurons differentiated from patient‐derived iPSCs, demonstrating that it acts as a S1R agonist, decreasing apoptosis, huntingtin aggregation, and oxidative stress ...
Ersilia Fornetti +11 more
wiley +1 more source
Hemodialysis International, EarlyView.ABSTRACT Introduction End stage kidney disease (ESKD) is associated with a high prevalence of depression and anxiety, arising from both biological factors and the psychosocial burden of chronic dialysis care. Approximately 25%–30% of dialysis patients experience clinically significant depressive symptoms when assessed by structured clinical interview ...
Kunal Malhotra +2 more
wiley +1 more source
Chronic tramadol abuse as a cause of serotonin syndrome. [PDF]
Toxicol Repvan Gemert RLA, Wansink L, Gresnigt FMJ.
europepmc +1 more source