Results 121 to 130 of about 307,503 (301)

Susceptibility of frogs to chytridiomycosis correlates with increased levels of immunomodulatory serotonin in the skin

, 2019
Chytridiomycosis, caused by the fungus Batrachochytrium dendrobatidis (Bd), is a skin disease responsible for the global decline of amphibians. Frog species and populations can vary in susceptibility, but this phenomenon remains poorly understood.
Grogan, Laura F., Joel P.A. Gummer, Laura F. Grogan, Gummer, Joel PA, Sieara C. Claytor, Berger, Lee, Brannelly, Laura A, Skerratt, Lee F., Webb, Rebecca J, Gummer, Joel P.A., Skerratt, Lee F, Roberts, Alexandra A., Laura A. Brannelly, Claytor, Sieara C., Brannelly, Laura A., Webb, Rebecca J., Lee Berger, Roberts, Alexandra A, Claytor, Sieara C, Lee F. Skerratt, Alexandra A. Roberts, Grogan, Laura F, Rebecca J. Webb   +22 more
core   +1 more source

Acute toxicity of ADB‐CHMINACA ‐ a case series of patients with pronounced central nervous symptoms including the posterior reversible encephalopathic syndrome

British Journal of Clinical Pharmacology, EarlyView.
Aim This report presents a series of 16 patients who were admitted to the emergency department following confirmed intake of the potent synthetic cannabinoid ADB‐CHMINACA. Methods The cases are drawn from a prospective observational study following the recreational use of synthetic cannabinoids.
Maren Hermanns‐Clausen, Michaela Sommer, Annette Zschiesche, Verena Angerer, Martin Scheu, Florian Eyer, Johannes Nadler, Volker Auwärter   +7 more
wiley   +1 more source

Boosting Serotonin Synthesis Is Not Sufficient to Improve Motor Coordination of Mecp2 Heterozygous Mouse Model of Rett Syndrome

Biomolecules
Motor deficit is a core symptom of Rett syndrome, a rare neurological disease caused in most cases by mutations of the methyl-CpG-binding protein2 (MECP2) gene. Serotonin reuptake inhibitors improve motor coordination in Mecp2 heterozygous (Het) mice and
Claudia Villani, Giuseppina Sacchetti, Roberto W. Invernizzi   +2 more
doaj   +1 more source

Long COVID-19 and Peripheral Serotonin: A Commentary and Reconsideration [PDF]

George M Anderson,1,2 Edwin H Cook,3 Randy D Blakely,4 James S Sutcliffe,5,6 Jeremy Veenstra-VanderWeele7,8 1Yale Child Study Center, Yale University School of Medicine, New Haven, CT, USA; 2Department of Laboratory Medicine, Yale University School of ...
Sutcliffe JS, Cook EH, Veenstra-VanderWeele J, Blakely RD, Anderson GM   +4 more
core  

Pulmonary inactivation of serotonin and site of serotonin pulmonary vasoconstriction

, 1980
To determine whether the site of serotonin-induced pulmonary vasoconstriction is influenced by serotonin uptake and inactivation within the lung, we utilized an isolated perfused left lower lobe of the dog lung, which could be perfused with flow in the ...
D. A. Rickaby, M. B. Maron, C. A. Dawson
core   +1 more source

Exploring new avenues: Psychedelic‐assisted therapy for young people

British Journal of Clinical Pharmacology, EarlyView.
Rates of mental illness in young people are increasing, whereas the development of novel mental health treatments has not significantly progressed. Psychedelic‐assisted therapy, using substances such as psilocybin and 3,4‐methylenedioxymethamphetamine (MDMA), has shown potential in the treatment of mental illnesses in the adult population, including ...
Ioanna Artemis Vamvakopoulou, Dasha Nicholls, David J. Nutt, Martina Di Simplicio   +3 more
wiley   +1 more source

Serotonin Toxicity

, 2017
Serotonin toxicity is a potentially life-threatening and severe illness that results from excess serotonin activity. It can be due to prescription medications, drug interactions, and sometimes intentional poisonings.
Patrick E. Britell, Charles M. Andrews
core   +1 more source

Clozapine:norclozapine ratio as a marker of metabolic risk and therapeutic response and effect of valproate on clozapine levels

British Journal of Clinical Pharmacology, EarlyView.
Aims Clozapine is the most effective antipsychotic in treatment‐resistant schizophrenia. Clozapine causes weight gain and increased diabetes risk. The role of its metabolite norclozapine and clozapine:norclozapine ratio (CLZ/NCLZ) in metabolic effects has been debated.
Susanna Maria Rask, Miina Lamminmäki, Olli Kampman, Mari Hämäläinen, Eeva Moilanen, Niko Seppälä, Anssi Solismaa   +6 more
wiley   +1 more source

Drug-associated serotonin syndrome in elderly patients: a comprehensive disproportionality analysis based on the FAERS database

Frontiers in Pharmacology
BackgroundThis study aims to identify drugs associated with serotonin syndrome in elderly patients by utilizing the FDA Adverse Event Reporting System (FAERS), to provide evidence-based references for safe clinical medication practices.MethodsThis study ...
Xiaozhi Li, Xiaofen Wen, Hongbo Fu, Xiaobing Hong, Danxia Lin, Xiaoyan Li, Zhikun Liang, Mengna Wang, Mengna Wang, Xihui Yu, Yanqiong Zhou, Xiajiong Luo   +11 more
doaj   +1 more source

Exposure to CYP2C19‐metabolized drugs following acute stroke: A longitudinal cohort study to inform implementation of CYP2C19 genotype testing

British Journal of Clinical Pharmacology, EarlyView.
Aims Cytochrome P450 2C19 (CYP2C19) genotype testing is recommended to guide antiplatelet selection after ischaemic stroke and transient ischaemic attack. CYP2C19 also metabolizes several commonly prescribed non‐antiplatelet drugs. We aimed to quantify exposure to CYP2C19‐metabolized drugs in stroke patients at hospital discharge and during ...
Cleodie C. Swire, Andrew T. Lambarth, Ayesha Saleem, Daniel R. Burrage   +3 more
wiley   +1 more source