Results 131 to 140 of about 275,194 (312)

Exploring new avenues: Psychedelic‐assisted therapy for young people

British Journal of Clinical Pharmacology, EarlyView.
Rates of mental illness in young people are increasing, whereas the development of novel mental health treatments has not significantly progressed. Psychedelic‐assisted therapy, using substances such as psilocybin and 3,4‐methylenedioxymethamphetamine (MDMA), has shown potential in the treatment of mental illnesses in the adult population, including ...
Ioanna Artemis Vamvakopoulou, Dasha Nicholls, David J. Nutt, Martina Di Simplicio   +3 more
wiley   +1 more source

Selective serotonin reuptake inhibitors in treatment of depression [PDF]

, 2017
Depression is a mental disorder, providing a major cause of morbidity worldwide. Several factors contribute to the development of depression. Regarding to the development of depression, many theories exist explaining the mechanisms from different point ...
Ghamary Gilvaei, Aryadokht
core  

Genes, Economics, and Happiness [PDF]

We explore the influence of genetic variation on subjective well-being by employing a twin design and genetic association study. In a nationally-representative twin sample, we first show that about 33% of the variation in life satisfaction is explained ...
Jan-Emmanuel De Neve, Nicholas A. Christakis, Bruno S. Frey, James H. Fowler   +3 more
core   +3 more sources

Applying machine learning to pharmacovigilance data: A proof‐of‐concept study

British Journal of Clinical Pharmacology, EarlyView.
Aim Machine learning (ML) applications in pharmacovigilance remain limited and underexplored. Using data from the French National pharmacovigilance database (FNPV), this proof‐of‐concept study aimed to assess the feasibility of using a ML algorithm—eXtreme Gradient Boosting (XGBoost)—combined with SHapley Additive exPlanations (SHAP) analysis, to ...
Romain Barus, Pauline Schiro, Jean‐Luc Faillie, Romane Freppel, Johana Béné, Claire de Canecaude, François Montastruc   +6 more
wiley   +1 more source

Drug-associated serotonin syndrome in elderly patients: a comprehensive disproportionality analysis based on the FAERS database

Frontiers in Pharmacology
BackgroundThis study aims to identify drugs associated with serotonin syndrome in elderly patients by utilizing the FDA Adverse Event Reporting System (FAERS), to provide evidence-based references for safe clinical medication practices.MethodsThis study ...
Xiaozhi Li, Xiaofen Wen, Hongbo Fu, Xiaobing Hong, Danxia Lin, Xiaoyan Li, Zhikun Liang, Mengna Wang, Mengna Wang, Xihui Yu, Yanqiong Zhou, Xiajiong Luo   +11 more
doaj   +1 more source

Gabapentinoids‐duloxetine combination therapy for chronic pain: A mechanism oriented rational to bridge theoretical knowledge and real life setting

British Journal of Clinical Pharmacology, EarlyView.
Chronic pain represents a complex debilitating condition that extends beyond the protective function of physiological pain, often persisting as an independent disease entity. Chronic primary and secondary pain syndromes reflect a multifaceted continuum involving nociceptive, neuropathic and nociplastic mechanisms.
Stefania Nobili, Maurizio Evangelista, Elena Lucarini, Elena G. Giugliano, Carla Ghelardini, Laura Micheli, Lorenzo Di Cesare Mannelli   +6 more
wiley   +1 more source

Antagonista do receptor da serotonina reverte a hipotensão e a hiporeatividade vascular no choque endotoxêmico em ratos [PDF]

, 2015
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências Biológicas, Programa de Pós-Graduação em Farmacologia, Florianópolis, 2015.O choque séptico é caracterizado principalmente por vasodilatação excessiva, hipotensão e ...
Metzker, Kiuanne Lino Lobo
core  

Clozapine:norclozapine ratio as a marker of metabolic risk and therapeutic response and effect of valproate on clozapine levels

British Journal of Clinical Pharmacology, EarlyView.
Aims Clozapine is the most effective antipsychotic in treatment‐resistant schizophrenia. Clozapine causes weight gain and increased diabetes risk. The role of its metabolite norclozapine and clozapine:norclozapine ratio (CLZ/NCLZ) in metabolic effects has been debated.
Susanna Maria Rask, Miina Lamminmäki, Olli Kampman, Mari Hämäläinen, Eeva Moilanen, Niko Seppälä, Anssi Solismaa   +6 more
wiley   +1 more source

Psychiatric and cognitive function in patients with serotonin producing neuroendocrine tumors

Translational Psychiatry
Cognitive and psychiatric problems are common in cancer patients, but literature on patients with neuroendocrine tumors (NET) is scarce. In a subset of these patients, the tumor produces serotonin, causing physical symptoms known as carcinoid syndrome ...
Maryse J. Luijendijk, Margot E. T. Tesselaar, Huub H. van Rossum, Martijn van Faassen, Catharina M. Korse, Wieke H. M. Verbeek, Jocelyn R. Spruit, Pernilla C. Scheelings, Eva H. Hooghiemstra, Ido P. Kema, Henricus G. Ruhé, Sanne B. Schagen, Froukje E. de Vries   +12 more
doaj   +1 more source

Exposure to CYP2C19‐metabolized drugs following acute stroke: A longitudinal cohort study to inform implementation of CYP2C19 genotype testing

British Journal of Clinical Pharmacology, EarlyView.
Aims Cytochrome P450 2C19 (CYP2C19) genotype testing is recommended to guide antiplatelet selection after ischaemic stroke and transient ischaemic attack. CYP2C19 also metabolizes several commonly prescribed non‐antiplatelet drugs. We aimed to quantify exposure to CYP2C19‐metabolized drugs in stroke patients at hospital discharge and during ...
Cleodie C. Swire, Andrew T. Lambarth, Ayesha Saleem, Daniel R. Burrage   +3 more
wiley   +1 more source