The serotonin transporter promotes a pathological estrogen metabolic pathway in pulmonary hypertension via cytochrome P450 1B1 pulmonary circulation [PDF]
, 2016 Pulmonary arterial hypertension (PAH) is a devastating vasculopathy that predominates in women and has been associated with dysregulated estrogen and serotonin signaling. Overexpression of the serotonin transporter (SERT+) in mice results in an estrogen-
Anagnostopoulou, Aikaterini +9 more
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Biological clocks in the duodenum and the diurnal regulation of duodenal and plasma serotonin. [PDF]
PLoS ONE, 2013 Serotonin in blood plasma is primarily synthesized in the duodenum, as brain derived serotonin does not cross the blood-brain barrier. Because serotonin in the brain and retina is synthesized under the control of a circadian clock, we sought to determine
Elizabeth Ebert-Zavos +3 more
doaj +1 more source
Role of serotonin on pituitary-thyroid functions and antioxidants in diabetic male rats
Kufa Journal for Veterinary Medical Sciences, 2023 Diabetes mellitus causes an increase in oxidative stress. Serotonin is a hormone its level in circulation reduced in diabetes; recently, it has been found to possess antioxidant qualities.
Sumayah Faruq Kasim, Fouad Ziedan Hamzah
doaj +1 more source
Brain serotonin synthesis capacity in obsessive-compulsive disorder: effects of cognitive behavioral therapy and sertraline. [PDF]
, 2018 Cognitive behavioral therapy (CBT) and selective serotonin reuptake inhibitors (SSRIs) are both effective treatments for some patients with obsessive-compulsive disorder (OCD), yet little is known about the neurochemical changes related to these ...
Barsoum, Amir +11 more
core +2 more sources
The effects of glycogen synthase kinase-3beta in serotonin neurons. [PDF]
PLoS ONE, 2012 Glycogen synthase kinase-3 (GSK3) is a constitutively active protein kinase in brain. Increasing evidence has shown that GSK3 acts as a modulator in the serotonin neurotransmission system, including direct interaction with serotonin 1B (5-HT1B) receptors
Wenjun Zhou +9 more
doaj +1 more source
Emerging Roles for Serotonin in Regulating Metabolism: New Implications for an Ancient Molecule.
Endocrine reviews, 2019 Serotonin is a phylogenetically ancient biogenic amine that has played an integral role in maintaining energy homeostasis for billions of years. In mammals, serotonin produced within the central nervous system regulates behavior, suppresses appetite and ...
Julian M. Yabut +5 more
semanticscholar +1 more source
Neuron, 2003 Rhythmic whisker movements, called "whisking," are produced by a brainstem central pattern generator (CPG) that uses serotonin to induce periodic firing in facial motorneurons. During active touch, motor cortex could regulate whisking frequency by controlling the rate of firing of the serotonergic neurons.
openaire +3 more sources
Serotonin and Noradrenaline Reuptake Inhibitors Improve Micturition Control in Mice [PDF]
, 2015 Poor micturition control may cause profound distress, because proper voiding is mandatory for an active social life. Micturition results from the subtle interplay of central and peripheral components.
Antonio, Caretta +6 more
core +4 more sources
Organization of Monosynaptic Inputs to the Serotonin and Dopamine Neuromodulatory Systems
Cell Reports, 2014 Serotonin and dopamine are major neuromodulators. Here, we used a modified rabies virus to identify monosynaptic inputs to serotonin neurons in the dorsal and median raphe (DR and MR).
Sachie K. Ogawa +4 more
doaj +1 more source
Serotonin: an overlooked regulator of endocytosis and endosomal sorting?
Biology Open, 2022 Serotonin is a neurotransmitter and a hormone that is typically associated with regulating our mood. However, the serotonin transporter and receptors are expressed throughout the body, highlighting the much broader, systemic role of serotonin in ...
Gregory Redpath, Nikita Deo
doaj +1 more source