Results 71 to 80 of about 274,362 (314)

Cyproheptadine in serotonin syndrome: A retrospective study

Journal of Family Medicine and Primary Care
Objective: Serotonin syndrome (SS) is an iatrogenic life-threatening condition caused by serotonergic agents. The treatment for SS involves the administration of a serotonin antagonist (cyproheptadine).
Sanjay Prakash, Harsh Patel, Sunil Kumar, Chetsi S. Shah   +3 more
doaj   +1 more source

The Role of Serotonin in the Influence of Intense Locomotion on the Behavior Under Uncertainty in the Mollusk Lymnaea stagnalis

Frontiers in Physiology, 2020
The role of serotonin in the immediate and delayed influence of physical exercise on brain functions has been intensively studied in mammals. Recently, immediate effects of intense locomotion on the decision-making under uncertainty were reported in the ...
Hitoshi Aonuma, Hitoshi Aonuma, Maxim Mezheritskiy, Boris Boldyshev, Yuki Totani, Dmitry Vorontsov, Igor Zakharov, Etsuro Ito, Varvara Dyakonova   +8 more
doaj   +1 more source

Functional Analysis of Ligand‐Gated Chloride Channels in a Cnidarian Sheds Light on the Evolution of Inhibitory Signaling

Advanced Science, EarlyView.
We uncover a large variety of putative inhibitory ligand‐gated ion channels (LGICs) in the phylum Cnidaria, the sister group to all bilaterian animals. Phylogenetic analysis suggests a complex evolutionary history of inhibitory LGICs with diverse neurotransmitter ligands.
Abhilasha Ojha, Linda Kloss, Juan D. Montenegro, Simone Albani, Audrey Ortega‐Ramírez, Mihaela Raycheva, Sylvia Joussen, Sabrina Kaul, Michèle Bachmann, Lisa Huf, Günther Schmalzing, Alison G. Cole, Ulrich Technau, Stefan Gründer   +13 more
wiley   +1 more source

The emerging role of serotonin in liver regeneration

Swiss Medical Weekly, 2012
Serotonin has a multifunctional role in many different organs serving either as a neurotransmitter in the central nervous system or a paracrine factor in the gastrointestinal tract.
George K Papadimas, Konstantinos N Tzirogiannis, Michael G Mykoniatis, Agni D Grypioti, Georgia A Manta, Georgios I Panoutsopoulos   +5 more
doaj   +1 more source

Table_1_Platelet, Plasma, Urinary Tryptophan-Serotonin-Kynurenine Axis Markers in Hyperacute Brain Ischemia Patients: A Prospective Study.DOCX

, 2022
Background and Purpose: Ischemic stroke is one of the most common causes of morbidity and mortality and has numerous clinical mimics. Previous studies have suggested a potential role of the tryptophan-serotonin (5-HT)-kynurenine (TSK) axis in ischemic ...
Olivier Richard (1466629), Odile Spreux-Varoquaux (360951), Vincent Feuga (11931209), Brigitte Bastenaire (11931203), Marie-Laure Chadenat (7313339), Yves Lambert (8270817), Jacques Callebert (257104), Fernando Pico (307596), Maryline Macquet (11931212), Philippe Jullien (360954), Jerôme Lambert (11931206), Luigi F. Saccaro (11931200), Jean-Marie Launay (161583)   +12 more
core   +1 more source

mGluR5 in ECCCK to BLA Circuit Modulates Depressive‐Like Phenotypes through CCK Signaling

Advanced Science, EarlyView.
Dysregulation of mGluR5 and CCK signaling contributes to major depressive disorder, yet circuit‐level mechanisms remain unclear. Here, the ECCCK→BLA pathway is identified as a critical regulator of affective behavior. mGluR5 modulates synaptic function and CCK signaling within this circuit, controlling stress susceptibility and depressive‐like states ...
Muhammad Asim, Huajie Wang, Gao Qianqian, Abdul Waris, Jufang He   +4 more
wiley   +1 more source

5-HT_FAsTR: a versatile, label-free, high-throughput, fluorescence-based microplate assay to quantify serotonin transport and release

Scientific Reports
The neurotransmitter serotonin plays a pivotal role in mood and depression. It also acts as a vasoconstrictor within blood vessels and is the main neurotransmitter in the gastrointestinal system.
Lina Bukowski, Markus Emanuel Strøm, Jens Lindengren Andersen, Jannick Bang Maesen, Lin Tian, Steffen Sinning   +5 more
doaj   +1 more source

Astrocytic Phenotypic Switching in Posterior Piriform Cortex Orchestrates Bone Cancer Pain–Depression Comorbidity via Purinergic–Noradrenergic Signaling

Advanced Science, EarlyView.
Bone cancer pain and depression share a common origin: astrocytic A2‐to‐A1 transition in the posterior piriform cortex. This phenotypic shift disrupts the ATP–adenosine–A2AR–norepinephrine axis, simultaneously driving nociceptive and affective dysfunction.
Jiang‐Ping Liu, Jun‐Han Zhang, Zhi‐Xuan Tan, Wei‐Bing Yan, Ya‐Ru Yuan, Yao Liu, Bing‐Di Wei, Meng‐Qi Ding, Zhuo‐Min Fu, Ying Liu, An‐Qi Wang, Lin Ma, Yong‐Hong Li, Er‐Qing Chai, Chao‐Jun Wei   +14 more
wiley   +1 more source

Addressing the serotonin hypothesis of depression through analyses of genetics, methylation and metabolite variations in glioma patients

Scientific Reports
Serotonin and serotonin metabolism has for decades been understood as playing a critical role in mood disorders and has more recently also been implicated in brain tumour biology.
Wendy Yi-Ying Wu, Beatrice Melin, Benny Björkblom, Rickard L. Sjöberg   +3 more
doaj   +1 more source

Serotonin and the gut microbiome: Pathways, functions, and health implications

The Microbe
Serotonin, an evolutionarily conserved molecule produced in the gut, plays a multifaceted role in host physiology. Several organs within the host can directly synthesize serotonin, yet its activity and secretion are intricately linked to the gut ...
Sarah Abubaker, Saba Miri, Riadh Hammami
doaj   +1 more source