Results 91 to 100 of about 307,503 (301)

Serotonin: Multiphoton imaging and relevant spectral data

, 2008
Coupling three-photon microscopy with automated stage movement can now produce a live high resolution map of the neurotransmitter serotonin in a single cross section of the whole rat brain.
Kaushalya, S. K., Nag, Suman, Balaji, J., Maiti, S.   +3 more
core   +1 more source

SCTR–Expressing Astrocyte–Serotonergic Neuron Signaling Drives Sexual Dimorphism in Depression Through KAT7/H4ac–Foxc2 Epigenetic Axis in an AMPK‐Dependent Manner

Advanced Science, EarlyView.
Astrocytic SCTR modulates depressive‐related phenotypes via AMPKα1, whereas lowered Mt1 blunts Megalin‐dependent AMPKα2 signaling in serotonergic neurons. Diminished AMPKα2 hinders KAT7 nuclear translocation, curtails KAT7 occupancy and H4K8ac at the Foxc2 promoter, and represses Foxc2 transcription, revealing cell‐type‐specific AMPK‐linked epigenetic ...
Fantao Meng, Jing Liu, Juanjuan Dai, Min Wu, Wentao Wang, Mengdi Zhang, Shujun Jiang, Yifan Cao, Lihong Xu, Lin Du, Dan Wang, Di Zhao, Gaofeng Qin, Dong Wang, Wei Li, Chen Li   +15 more
wiley   +1 more source

Contribution of gene-modified mice and rats to our understanding of the cardiovascular pharmacology of serotonin

, 2010
International audienceThis review focuses on new insights provided by gene-modified animals into the cardiovascular pharmacology of serotonin. During their development, mice mutant for tryptophan hydroxylase 1 and lacking peripheral serotonin, or mutant ...
Tarak Ayadi, Laurent Monassier, Luc Maroteaux, Monassier, Laurent, Ayadi, Tarak, Maroteaux, Luc, Marc André Laplante, Stéphane Doly, Laplante, Marc André, Doly, Stéphane   +9 more
core   +1 more source

EphB1 Receptor Blockade Augments Morphine Antinociception via Inhibiting GRK2‐Mediated µ‐Opioid Receptor Internalization

Advanced Science, EarlyView.
Administration of opioids activates ephrinB2‐EphB1 receptor signaling. Activated EphB1 receptors induce GRK2‐mediated phosphorylation of MOR at Ser375, which initiates the internalization of MOR and reduces opioid antinociception at the behavioral level. ABSTRACT Opioids are the primary treatment for severe pain in clinical practice.
Bo Peng, Xiaqing Lin, Hongyu Yao, Cheng Li, Huabao Liao, Yuexin Liu, Boxu Cao, Xue‑Jun Song   +7 more
wiley   +1 more source

Correlation Between Blood Serotonin Level with Consciousness Level and Depression Symptoms in moderate Brain Injury Patients [PDF]

, 2010
To analyze a correlation between blood serotonin level, level of consciousness after resuscitation, and depression symptoms to reveal pathological neurobiochemistry level on moderate brain injury patients.
Parenrengi, M Arifin, Maria Maramis, Margarita, Kusuma, Andre   +2 more
core   +1 more source

Serotonin Enhances Beta-Endorphin Secretion to Lower Plasma Glucose in Streptozotocin-Induced Diabetic Rats

, 2008
Although serotonin, serotonin uptake inhibitors and serotonin precursors (including tryptophan or 5- hydroxytryptophan) are known to have hypoglycemic action in rodents or human, it is not clear whether serotonin has hypoglycemic effect in streptozotocin-
紀宗呈;何宜錦;李水盛;鄭瑞棠;蘇銘嘉, CHI, TZONG-CHERNG;HO, YI-JIN;LEE, SHOEI -SHENG;CHENG, JUEI-TANG;SU, MING-JAI   +1 more
core  

Gut Microbiota‐Derived Indole‐3‐Acetaldehyde Contributes to the Disease‐Alleviating Effects of Kurarinone in Experimental Autoimmune Encephalomyelitis

Advanced Science, EarlyView.
Kurarinone ameliorates EAE via the gut microbiota‐indole‐3‐acetaldehyde‐AhR axis. Kurarinone reshapes gut microbiota and increases Akkermansia muciniphila, which promotes intestinal indole‐3‐acetaldehyde production. Indole‐3‐acetaldehyde crosses the intestinal barrier, activates AhR in CD4+ T cells, upregulates SOCS1/3, inhibits JAK2 and STAT3/4 ...
Xinyan Han, Jiaqi Ding, Zonghao Pan, Weitai He, Xue Kang, Cong Zhao, Yi Li, Di Wu, Hongzeng Li, Kaixi Ren, Jiaji Lin, Jun Guo   +11 more
wiley   +1 more source

Blocking Honeybee Preference for Neonicotinoids by Interfering With Dopamine Signaling

Advanced Science, EarlyView.
Honeybees (Apis mellifera) paradoxically prefer nectar containing the harmful neonicotinoid thiamethoxam. This preference is associated with transient brain dopamine elevation during proboscis extension reflex (PER) responses and active feeding, and is reduced by the dopamine receptor antagonist fluphenazine.
Jing Li, Yuan Ge, Wangjiang Feng, David C. Lyon, Pingli Dai, Yong‐Jun Liu   +5 more
wiley   +1 more source

ADNP‐Related Helsmoortel–Van der Aa Syndrome: A Review of the Literature and Clinical Recommendations for Assessment and Monitoring

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT ADNP‐related Helsmoortel–Van der Aa syndrome (ADNP‐related HVDAS) is a single gene form of autism spectrum disorder (ASD) caused by pathogenic sequence variants in the activity‐dependent neuroprotective protein (ADNP) gene. In addition to ASD, ADNP‐related HVDAS is associated with a wide range of cognitive, behavioral, and physical health ...
Jarrett Fastman, Ana Kolevzon, Paige Siper, Tess Levy, Jeffrey M. Saland, Yitzchak Frank, Robert Rapaport, Kayla Kupietzky, William E. Bennett Jr, Bruce Gelb, Sandra Bedrosian Sermone, Alexander Kolevzon   +11 more
wiley   +1 more source

Psychobiological studies showing the serotonin involvement in cognition-related behavioral performance

, 2013
Serotonin most often acts as an inhibitory neurotransmitter which also modulates post-synaptic activity within other neurotransmitter systems. Serotonin is synthesized from the essential amino acid tryptophan in Raphe complex neurons which innervate ...
Gonzalez-Burgos, I., Feria-Velasco, A.
core   +1 more source