Results 61 to 70 of about 234,379 (321)

A Hydrophobic Gate in an Ion Channel: The Closed State of the Nicotinic Acetylcholine Receptor [PDF]

Physical Biology, 3(2):147-159, 2006, 2005
The nicotinic acetylcholine receptor (nAChR) is the prototypic member of the `Cys-loop' superfamily of ligand-gated ion channels which mediate synaptic neurotransmission, and whose other members include receptors for glycine, gamma-aminobutyric acid, and serotonin.
arxiv   +1 more source

Microneedles at the Forefront of Next Generation Theranostics

Advanced Science, EarlyView.
The TOC figure illustrates the revolutionary role of microneedles in modern medicine, showcasing their dual diagnostic and therapeutic functions. On the left, microneedles access interstitial fluid for real‐time monitoring of biomarkers like glucose and hormones.
Chan Wang, Yuan Yang, Jiaqi Zhang, Hanrui Zhang, Qian Wang, Shengmei Ma, Pengfei Zhao, Zhou Li, Yuxin Liu   +8 more
wiley   +1 more source

Affective and cognitive prefrontal cortex projections to the lateral habenula in humans [PDF]

, 2014
Anterior insula (AI) and dACC are known to process information about pain, loss, adversities, bad, harmful or suboptimal choices and consequences that threaten survival or well-being. Pain and loss activate also pregenual ACC (pgACC), linked to sad thoughts, hurt and regrets.
arxiv   +1 more source

A Compound Screen Based on Isogenic hESC‐Derived β Cell Reveals an Inhibitor Targeting ZnT8‐Mediated Zinc Transportation to Protect Pancreatic β Cell from Stress‐Induced Cell Death

Advanced Science, EarlyView.
Pancreatic β cell loss by cellular stress contributes to diabetes pathogenesis. The study demonstrates that WFS1–ZnT8–zinc axis regulates vicious cycle of zinc transportation and cellular stress in pancreatic β cell. Based on that, the study applies a strategy for compound screening targeting ZnT8 based on human models, and identifies anisomycin, as a ...
Rui Hu, Qing Ma, Yunhui Kong, Zhaoyue Wang, Minglu Xu, Xiangyi Chen, Yajuan Su, Tinghui Xiao, Qing He, Xuan Wang, Wenjun Xu, Yiling Yang, Xushu Wang, Xiaobo Li, Yanfang Liu, Shuangshuang Chen, Rui Zhao, Meng Guo, Gaowei Wang, Weida Li   +19 more
wiley   +1 more source

Within‐day bidirectional associations between physical activity and affect: A real‐time ambulatory study in persons with and without depressive and anxiety disorders

Depression and Anxiety, Volume 39, Issue 12, Page 922-931, December 2022., 2022
Abstract Background Ambulatory assessments offer opportunities to study physical activity level (PAL) and affect at the group and person‐level. We examined bidirectional associations between PAL and affect in a 3‐h timeframe and evaluated whether associations differ between people with and without current or remitted depression/anxiety.
Sonia Difrancesco, Brenda W. J. H. Penninx, Kathleen R. Merikangas, Albert M. van Hemert, Harriëtte Riese, Femke Lamers   +5 more
wiley   +1 more source

Sustained Exposure to 3,4-Methylenedioxymethamphetamine Induces the Augmentation of Exocytotic Serotonin Release in Rat Organotypic Raphe Slice Cultures

Journal of Pharmacological Sciences, 2010
3,4-Methylenedioxymethamphetamine (MDMA) causes serotonin efflux via serotonin transporter. Recently, we have reported that sustained exposure to MDMA induced an augmentation of serotonin release in rat raphe serotonergic slice cultures.
Kazuki Nagayasu, Maiko Kitaichi, Hisashi Shirakawa, Takayuki Nakagawa, Shuji Kaneko   +4 more
doaj  

Direct serotonin release in humans shapes aversive learning and inhibition

Nature Communications
The role of serotonin in human behaviour is informed by approaches which allow in vivo modification of synaptic serotonin. However, characterising the effects of increased serotonin signalling in human models of behaviour is challenging given the ...
Michael J. Colwell, Hosana Tagomori, Fei Shang, Hoi Iao Cheng, Chloe E. Wigg, Michael Browning, Philip J. Cowen, Susannah E. Murphy, Catherine J. Harmer   +8 more
doaj   +1 more source

Decoding Blastocystis‐Driven Mechanisms in Gut Microbiota and Host Metabolism

Advanced Science, EarlyView.
Blastocystis, a prevalent gut microbe, interacts with the host through metabolic and immune pathways, influencing cardiometabolic health. This perspective explores its role in modulating short‐chain fatty acid production, tryptophan metabolism, and immune signaling, potentially impacting cholesterol absorption, glucose metabolism, and vascular health ...
Lei Deng, Kevin SW Tan
wiley   +1 more source

L-Dopa and Brain Serotonin System Dysfunction

Toxics, 2015
L-dopa is used to treat the motor symptoms associated with Parkinson’s disease, a neurodegenerative movement disorder characterized by a loss of dopamine neurons.
Branden J. Stansley, Bryan K. Yamamoto
doaj   +1 more source

The Role of Serotonin in the Influence of Intense Locomotion on the Behavior Under Uncertainty in the Mollusk Lymnaea stagnalis

Frontiers in Physiology, 2020
The role of serotonin in the immediate and delayed influence of physical exercise on brain functions has been intensively studied in mammals. Recently, immediate effects of intense locomotion on the decision-making under uncertainty were reported in the ...
Hitoshi Aonuma, Hitoshi Aonuma, Maxim Mezheritskiy, Boris Boldyshev, Yuki Totani, Dmitry Vorontsov, Igor Zakharov, Etsuro Ito, Varvara Dyakonova   +8 more
doaj   +1 more source