Results 81 to 90 of about 234,379 (321)

The emerging role of serotonin in liver regeneration

Swiss Medical Weekly, 2012
Serotonin has a multifunctional role in many different organs serving either as a neurotransmitter in the central nervous system or a paracrine factor in the gastrointestinal tract.
George K Papadimas, Konstantinos N Tzirogiannis, Michael G Mykoniatis, Agni D Grypioti, Georgia A Manta, Georgios I Panoutsopoulos   +5 more
doaj   +1 more source

Item-Level Heterogeneous Treatment Effects of Selective Serotonin Reuptake Inhibitors (SSRIs) on Depression: Implications for Inference, Generalizability, and Identification [PDF]

Epidemiol. Methods 2024; 13(1): 20240006
In analysis of randomized controlled trials (RCTs) with patient-reported outcome measures (PROMs), Item Response Theory (IRT) models that allow for heterogeneity in the treatment effect at the item level merit consideration. These models for ``item-level heterogeneous treatment effects'' (IL-HTE) can provide more accurate statistical inference, allow ...
arxiv   +1 more source

Advanced Microfluidic‐Based Wearable Electrochemical Sensors for Continuous Biochemical Monitoring

Advanced Electronic Materials, EarlyView.
Microfluidic‐based wearable electrochemical sensors are transforming non‐invasive health monitoring through real‐time biochemical analysis of sweat, saliva, and interstitial fluid. This review explores advances in microfluidic design, fabrication, and sensor integration while addressing biofluid variability, material compatibility, and scalability.
Sehyun Park, Seongyeop Kim, Soojin Lee, Vladimir V. Tsukruk, SeungHyun Park, Hyo‐Ryoung Lim   +5 more
wiley   +1 more source

Serotonin modulates Campylobacter jejuni physiology and in vitro interaction with the gut epithelium

Poultry Science, 2021
Microbial endocrinology, which is the study of neurochemical-based host–microbe interaction, has demonstrated that neurochemicals affect bacterial pathogenicity.
Joshua M. Lyte, Sandip Shrestha, Basanta R. Wagle, Rohana Liyanage, Diego A. Martinez, Annie M. Donoghue, Karrie M. Daniels, Mark Lyte   +7 more
doaj  

Theoretical frameworks for neuroeconomics of intertemporal choice [PDF]

Journal of Neuroscience, Psychology, and Economics, Vol 2(2), Nov 2009, 75-90, 2011
Intertemporal choice has drawn attention in behavioral economics, econophysics, and neuroeconomics. Recent studies in mainstream economics have mainly focused on inconsistency in intertemporal choice (dynamic inconsistency); while impulsivity/impatience in intertemporal choice has been extensively studied in behavioral economics of addiction.
arxiv  

Designed Biomaterial‐Enhanced Cell Transplantation for Neural Tissue Engineering

Aggregate, EarlyView.
Biomaterials offer a promising solution for cell transplantation in the central nervous system by creating a protective environment that enhances cell survival, integration, and functional recovery in preclinical models of neurological disorders. ABSTRACT Cell transplantation therapy in the central nervous system is hindered by limited survival and ...
Yun Tang, Alice Le Friec, Menglin Chen, Di Sun   +3 more
wiley   +1 more source

Pain‐autonomic measures reveal nociceptive sensitization in complex regional pain syndrome

European Journal of Pain, Volume 27, Issue 1, Page 72-85, January 2023., 2023
Abstract Background Allodynia and hyperalgesia are common signs in individuals with complex regional pain syndrome (CRPS), mainly attributed to sensitization of the nociceptive system. Appropriate diagnostic tools for the objective assessment of such hypersensitivities are still lacking, which are essential for the development of mechanism‐based ...
Paulina S. Scheuren, Iara De Schoenmacker, Jan Rosner, Florian Brunner, Armin Curt, Michèle Hubli   +5 more
wiley   +1 more source

Enantioselective CE–MS analysis of ketamine metabolites in urine

ELECTROPHORESIS, Volume 44, Issue 1-2, Page 125-134, January 2023., 2023
Abstract The chiral drug ketamine has long‐lasting antidepressant effects with a fast onset and is also suitable to treat patients with therapy‐resistant depression. The metabolite hydroxynorketamine (HNK) plays an important role in the antidepressant mechanism of action.
Friederike A. Sandbaumhüter, Jordan T. Aerts, Regula Theurillat, Per E. Andrén, Wolfgang Thormann, Erik T. Jansson   +5 more
wiley   +1 more source

Misplaced Confidence in Observed Power [PDF]

arXiv, 2019
A recently published randomized controlled trial in JAMA investigated the impact of the selective serotonin reuptake inhibitor, escitalopram, on the risk of major adverse events (MACE). The authors estimated a hazard ratio (HR) of 0.69 (95% CI: 0.49, 0.96; $p$ = 0.03) and then attempted to calculate how much statistical power their study (test) had ...
arxiv  

The cumulative analgesic effect of repeated electroacupuncture is modulated by Adora3 in the SCDH of mice with neuropathic pain

Animal Models and Experimental Medicine, EarlyView.
Neuropathic pain management via repeated electroacupuncture. Abstract Background Existing remedial approaches for relieving neuropathic pain (NPP) are challenging and open the way for alternative therapeutic measures such as electroacupuncture (EA). The mechanism underlying the antinociceptive effects of repeated EA sessions, particularly concerning ...
Faisal Ayub Kiani, Hao Li, Panpan Guo, Qiulin Zhang, Mahmoud M. Abouelfetouh, Mingxing Ding, Yi Ding   +6 more
wiley   +1 more source