Results 121 to 130 of about 7,760 (160)

Targeting the 5-HT_2A Receptor for Developing Psychedelic Drugs and Beyond. [PDF]

J Med Chem
Ali S, Tian X, Cunningham KA, Zhou J.
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Potentiation of 3,4-methylenedioxymethamphetamine-induced dopamine release and serotonin neurotoxicity by 5-HT2 receptor agonists

European Journal of Pharmacology, 1994
The effects of the 5-HT2 receptor agonists 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI) and 5-methoxy-N,N-dimethyltryptamine (5-MeODMT) on 3,4-methylenedioxymethamphetamine (MDMA)-induced dopamine release and 5-HT depletion in the striatum were studied.
G A, Gudelsky, B K, Yamamoto, J F, Nash
openaire   +4 more sources

Selective Serotonin Reuptake Inhibitors and 5-HT2 Receptor Agonists Have Distinct, Sleep-state Dependent Effects on Postictal Breathing in Amygdala Kindled Mice

Neuroscience, 2023
Seizures can cause profound breathing disruptions. Seizures arising from sleep cause greater breathing impairment than those emerging from wakefulness and more often result in sudden unexpected death in epilepsy (SUDEP). The neurotransmitter serotonin (5-HT) plays a major role in respiration and sleep-wake regulation.
Katelyn G. Joyal, Alexandra N. Petrucci, Mydirah V. Littlepage-Saunders, Nicole A. Boodhoo, Linder H. Wendt, Gordon F. Buchanan   +5 more
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Hypothalamic paraventricular nucleus lesions differentially affect serotonin-1A (5-HT1A) and 5-HT2 receptor agonist-induced oxytocin, prolactin, and corticosterone responses

Endocrinology, 1994
A number of receptor subtypes mediate hormonal responses to serotonin (5-HT). To test the hypothesis that the hypothalamic paraventricular nucleus (PVN) mediates 5-HT1A and 5-HT2 receptor-mediated oxytocin, PRL, and corticosterone responses, we studied the effects of the 5-HT1A agonist ipsapirone and the 5-HT2A/2C agonist 1-(2,5-dimethoxy-4-iodophenyl ...
G, Bagdy, G B, Makara
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Evidence that the serotonin agonist, DOI, increases renin secretion and blood pressure through both central and peripheral 5-HT2 receptors.

The Journal of Pharmacology and Experimental Therapeutics, 1991
DOI [(+/-)-1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane HCI] is a serotonin (5-HT1C/5-HT2) agonist, with potent cardiovascular effects. The purpose of the present studies was to determine the identity and location of the 5-HT receptor subtype(s) mediating the renin and blood pressure responses to DOI.
P A, Rittenhouse, E A, Bakkum, L D, Van de Kar   +2 more
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Rapid desensitization and resensitization of 5-HT2 receptor mediated phosphatidyl inositol hydrolysis by serotonin agonists in quiescent calf aortic smooth muscle cells

Life Sciences, 1990
Agonist regulation of 5-hydroxytryptamine2 (5-HT2) receptors was studied in calf aortic smooth muscle cultures incubated in a quiescent, defined synthetic medium that does not stimulate cell proliferation, but that provides cells with supplements that maintain cell viability.
P J, Pauwels, P, Van Gompel, J E, Leysen
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Effect of antagonists and agonists of 5-HT1 and 5-HT2 serotonin receptors on the predator aggressiveness of wild norway rats

Bulletin of Experimental Biology and Medicine, 1996
The effect of agonists of serotonin receptors on predator aggressiveness (the “mouse killing” test) is studied on Norway rats. Ipsapirone and eltoprazine are found to have no effect on predator aggressiveness. 1-[3-(Trifluoromethyl)phenyl]piperazine×HCl (TFMPP) considerably reduces aggressiveness.
N. K. Popova, E. M. Nikulina, S. N. Shigantsov, I. F. Plyusnina, T. G. Amstislavskaya   +4 more
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1-(2-Aminoethyl)-3-methyl-8,9-dihydropyrano[3,2-e]indole: a rotationally restricted phenolic analog of the neurotransmitter serotonin and agonist selective for serotonin (5-HT2-type) receptors

Journal of Medicinal Chemistry, 1992
A series of rotationally restricted phenolic analogs of the neurotransmitter serotonin has been synthesized with the 5-hydroxyindole portion of serotonin replaced by a dihydropyrano[3,2-e]-indole (1, 3, 4, and 5) and a dihydropyrano[2,3-f]indole (2). The receptor binding profile of these compounds has been studied and compared to the natural substrate ...
J E, Macor, C B, Fox, C, Johnson, B K, Koe, L A, Lebel, S H, Zorn   +5 more
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The role of serotonin-2 (5-HT2) and dopamine receptors in the behavioral actions of the 5-HT2A/2C agonist, DOI, and putative 5-HT2C inverse agonist, SR46349B

Psychopharmacology, 2010
Atypical antipsychotic efficacy is often attributed to actions at serotonin-2 (5-HT(2)) and dopamine receptors, indicating a potential benefit of understanding the interplay between these systems. Currently, it is known that 5-HT(2) receptors modulate dopamine release, although the role of specific dopamine receptors in 5-HT(2)-mediated behavior is not
Laura C, Scarlota, John A, Harvey, Vincent J, Aloyo   +2 more
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Serotonin Agonist Induced Corticosterone and Prolactin Secretion: Role of 5-HT2 and 5-HT1A Receptors

1990
Serum concentrations of corticosterone were increased following activation of 5-HT1A receptors with 8-OH-DPAT or activation of 5-HT2 receptors with MK-212 or DOI. The repeated administration of a 5-HT1A agonist, 5-MeODMT, selectively diminished the corticosterone response to 8-OH-DPAT, whereas the repeated administration of a 5-HT2 agonist, DOI ...
G. A. Gudelsky, J. F. Nash, J. I. Koenig, H. Y. Meltzer   +3 more
openaire   +1 more source