Results 131 to 140 of about 7,760 (160)

Selectivity of serotonergic drugs for multiple brain serotonin receptors. Role of [3H]-4-bromo-2,5-dimethoxyphenylisopropylamine ([3H]DOB), a 5-HT2 agonist radioligand.

Biochemical pharmacology, 1987
The affinities of putative serotonin receptor agonists and antagonists for 5-HT1A, 5-HT1B, 5-HT1C, and 5-HT2 receptors were assayed using radioligand binding assays. The 5-HT1 sites were labeled with the agonist radioligands [3H]-8-hydroxy-2-(di-n-propylamino)-tetralin [3H]-8-OH-DPAT, [3H]-5-HT, and [3H]mesulergine.
M, Titeler, R A, Lyon, K H, Davis, R A, Glennon   +3 more
openaire   +2 more sources

Effects of serotonin and the 5-HT2/1C receptor agonist DOI on neurons of the cerebellar dentate/interpositus nuclei: possible involvement of a GABAergic interneuron

European Journal of Pharmacology, 1993
The present study was designed to examine the effects of iontophoretically applied serotonin (5-HT) on neurons of the cerebellar dentate/interpositus nuclei in an in vitro slice preparation and to determine if the 5-HT2/1C receptor subtype could be responsible for mediating any effects noted with 5-HT.
P A, Cumming-Hood, H K, Strahlendorf, J C, Strahlendorf   +2 more
openaire   +2 more sources

Effects of serotonin 5-HT1 and 5-HT2 Receptor Agonists in a Conditioned Taste Aversion Paradigm in the Rat

Pharmacology Biochemistry and Behavior, 2000
Although 5-HT(1/2) receptor agonists can inhibit ingestive behavior, it remains unclear whether this effect is confounded by drug-induced "malaise." The present study assessed the potential of such compounds to induce conditioned taste aversion (CTA), a possible correlate of aversive stimulus properties.
J, De Vry, G, Eckel, E, Kuhl, R, Schreiber   +3 more
openaire   +2 more sources

Serotonin and its 5-HT2 receptor agonist DOI hydrochloride inhibit the oxidative burst in total leukocytes but not in isolated neutrophils

Life Sciences, 2010
Serotonin (5-HT) is capable of reducing the oxidative burst of professional phagocytes. In this study, we investigated whether 5-HT mediates this modulation via 5-HT receptors (5-HTR) or whether this is due instead to 5-HT antioxidative properties.The leukocytes or polymorphonuclear leukocytes (PMNL) were isolated from human blood, and their ability to
Lucie, Pracharová, Katerina, Okénková, Antonín, Lojek, Milan, Cíz   +3 more
openaire   +2 more sources

Differential Actions of Antiparkinson Agents at Multiple Classes of Monoaminergic Receptor. III. Agonist and Antagonist Properties at Serotonin, 5-HT1 and 5-HT2, Receptor Subtypes

The Journal of Pharmacology and Experimental Therapeutics, 2002
Although certain antiparkinson agents interact with serotonin (5-HT) receptors, little information is available concerning functional actions. Herein, we characterized efficacies of apomorphine, bromocriptine, cabergoline, lisuride, piribedil, pergolide, roxindole, and terguride at human (h)5-HT(1A), h5-HT(1B), and h5-HT(1D) receptors [guanosine 5'-O ...
Adrian, Newman-Tancredi, Didier, Cussac, Yann, Quentric, Manuelle, Touzard, Laurence, Verrièle, Nathalie, Carpentier, Mark J, Millan   +6 more
openaire   +2 more sources

Serotonin, dopamine, noradrenaline and their metabolites: Levels in the brain of the house cricket (Acheta domesticus L.) during a 24-hour period and after administration of quipazine—a 5-HT2 receptor agonist

Comparative Biochemistry and Physiology Part C: Comparative Pharmacology, 1991
1. The levels of 5-HT, DA, NA and DA metabolites (NADA, DOPAC) measured by HPLC (with electrochemical detection) in the brain of the house cricket did not change over a 24-hr period. The level of 5-HIAA, a 5-HT metabolite, was below the limit of detection. 2. The 5-HT and DOPAC levels decreased and NADA increased after quipazine injection but DA and NA
E, Pyza, K, Gołembiowska, L, Antkiewicz-Michaluk   +2 more
openaire   +2 more sources

Uniform pattern of immunohistochemical localization of serotonin 5-HT2 receptors in human aortic, mitral, pulmonary and tricuspid heart valves: Implication for the pathomechanism of valvular heart disease following treatment with dopamine agonists

Basal Ganglia, 2012
Abstract It has been suggested that the activation of the serotonin (5-hydroxytryptamine, 5-HT) receptor family 5-HT 2 , in particular the subtype 5-HT 2B , is a key step in the progression of drug-induced valvular heart disease (VHD). However, the localisation of 5-HT 2 receptors in human valves have not been reported.
Camelia-Maria Monoranu, Stefan Kircher, Angelika Schmitt, Peter Riederer, Manfred Gerlach   +4 more
openaire   +1 more source

Synthesis and Structure–Activity Relationships of 2,5-Dimethoxy-4-Substituted Phenethylamines and the Discovery of CYB210010: A Potent, Orally Bioavailable and Long-Acting Serotonin 5-HT₂ Receptor Agonist

Journal of Medicinal Chemistry
Structure-activity studies of 4-substituted-2,5-dimethoxyphenethylamines led to the discovery of 2,5-dimethoxy-4-thiotrifluoromethylphenethylamines, including CYB210010, a potent and long-acting serotonin 5-HT2 receptor agonist. CYB210010 exhibited high agonist potency at 5-HT2A and 5-HT2C receptors, modest selectivity over 5-HT2B, 5-HT1A, 5-HT6, and ...
Geoffrey B. Varty, Clinton E. Canal, Tina A. Mueller, Joshua A. Hartsel, Richa Tyagi, Ken Avery, Michael E. Morgan, Amy C. Reichelt, Pradip Pathare, Erik Stang, Michael G. Palfreyman, Alex Nivorozhkin   +11 more
openaire   +2 more sources

THE ROLE OF AN AGONIST OF 5-HT2 SEROTONIN RECEPTORS IN THE LABILITY OF THE HEART RATE

Scientific Notes Kazan Bauman State Academy of Veterinary Medicine, 2022
R.R. Abzalov, N.I. Abzalov, R.A. Abzalov
openaire   +1 more source

[3H]DOB: A specific agonist radioligand for 5-HT2 serotonin receptors

European Journal of Pharmacology, 1985
M, Titeler, K, Herrick, R A, Lyon, J D, McKenney, R A, Glennon   +4 more
openaire   +2 more sources