Results 1 to 10 of about 40,822 (145)

Ergotamine enhances circadian amplitude and diurnally mitigates nitroglycerin-induced mechanical hypersensitivity [PDF]

open access: yesThe Journal of Headache and Pain
Background Cluster headache and migraine have a circadian timing of attacks and are linked to the trigeminovascular system. Recently the trigeminal ganglion was found to have a strong circadian rhythm, with the serotonin 2A receptor identified as a clock-
Chorong Han   +8 more
doaj   +2 more sources

The Role of Serotonin in Breast Cancer Stem Cells

open access: yesMolecules, 2021
Breast tumors were the first tumors of epithelial origin shown to follow the cancer stem cell model. The model proposes that cancer stem cells are uniquely endowed with tumorigenic capacity and that their aberrant differentiation yields non-tumorigenic ...
William D. Gwynne   +3 more
doaj   +1 more source

Effects of Ramosetron on Nausea and Vomiting Following Spinal Surgery: A Meta-Analysis

open access: yesCurrent Therapeutic Research, 2022
: Background: Spinal surgery is associated with severe pain within the first few days after surgery. Opioids are commonly used to control postoperative pain, but these can lead to postoperative nausea and vomiting (PONV).
Yiyun Lin, MD   +4 more
doaj   +1 more source

Progress in Investigational Agents Targeting Serotonin-6 Receptors for the Treatment of Brain Disorders

open access: yesBiomolecules, 2023
Serotonin (5-HT) plays an important role in the regulation of several basic functions of the central and peripheral nervous system. Among the 5-HT receptors, serotonin-6 (5-HT6) receptor has been an area of substantial research.
Ramakrishna Nirogi   +9 more
doaj   +1 more source

Management of chemotherapy induced emesis [PDF]

open access: yesArchive of Oncology, 2004
Important progress has been achieved in the last few years in the prevention of chemotherapy-induced nausea and vomiting thanks to the introduction in clinical practice first of the 5-HT3 antagonists and of the NK1 antagonists more recently.
Roila Fausto
doaj   +1 more source

The antidepressant 5-HT2A receptor antagonists pizotifen and cyproheptadine inhibit serotonin-enhanced platelet function. [PDF]

open access: yesPLoS ONE, 2014
There is considerable interest in defining new agents or targets for antithrombotic purposes. The 5-HT2A receptor is a G-protein coupled receptor (GPCR) expressed on many cell types, and a known therapeutic target for many disease states.
Olivia A Lin   +4 more
doaj   +1 more source

INVOLVEMENT OF MONOAMINERGIC SYSTEM IN THE ANTIDEPRESSANT-LIKE EFFECT OF Ocimum sanctum (LINN.) LEAVES EXTRACT IN TAIL SUSPENSION TEST IN MICE

open access: yesJIIS: Jurnal Ilmiah Ibnu Sina, 2021
Depression is a psychiatric disorder characterized by decreased mood and affects daily activities.The development of herbal ingredients as complementary therapy becomes increasing in line with the number of patients who avoid side effects in ...
Ridho Islamie   +4 more
doaj   +3 more sources

Combined Antagonism of 5-HT2 and NMDA Receptors Reduces the Aggression of Monoamine Oxidase a Knockout Mice

open access: yesPharmaceuticals, 2022
The enzyme monoamine oxidase A (MAOA) catalyzes the degradation of several neurotransmitters, including serotonin. A large body of evidence has shown that genetic MAOA deficiency predisposes humans and mice to aggression and antisocial behavior.
Roberto Frau   +4 more
doaj   +1 more source

Food Anticipatory Activity on Circadian Time Scales Is Not Dependent on Central Serotonin: Evidence From Tryptophan Hydroxylase-2 and Serotonin Transporter Knockout Mice

open access: yesFrontiers in Molecular Neuroscience, 2020
A number of studies implicate biogenic amines in regulating circadian rhythms. In particular, dopamine and serotonin influence the entrainment of circadian rhythms to daily food availability.
Christian M. Gallardo   +2 more
doaj   +1 more source

Identification, functional characterization and pharmacological profile of a serotonin type-2b receptor in the medically important insect, Rhodnius prolixus

open access: yesFrontiers in Neuroscience, 2015
In the Chagas disease vector, Rhodnius prolixus, two diuretic hormones act synergistically to dramatically increase fluid secretion by the Malpighian tubules (MTs) during the rapid diuresis that is initiated upon engorgement of vertebrate blood.
Jean-Paul V Paluzzi   +10 more
doaj   +1 more source

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