Results 51 to 60 of about 235,344 (293)

Cholestatic Pruritus in Children: Conventional Therapies and Beyond

Biology, 2023
Pruritus in the setting of cholestatic liver disease is difficult to treat and occurs in patients ranging in age from infancy to adulthood. Likely multifactorial in etiology, this symptom often involves multimodal therapy targeting several pathways and ...
Minna Rodrigo, Xinzhong Dong, Daphne Chien, Wikrom Karnsakul   +3 more
doaj   +1 more source

Charting Endocrine Progenitors Across Species and Organs

Advanced Science, EarlyView.
Endocrine progenitors give rise to the hormone‐producing cells of the pancreas and intestine. Using single‐cell multiomics and proteomics, this study compares these progenitors across species, systems, and organs, mapping the conserved and species‐specific gene regulatory networks that guide their formation.
Changying Jing, Michael Sterr, Özüm Sehnaz Caliskan, Lama Saber, Nicole Katarina Rogers, Samuel Ogden, Kei Kozawa, Christos Karampelias, Jessica Jaki, Aimée Bastidas‐Ponce, Falk Janos Farkas, Oliver Czarnecki, Osvaldo Rodrigues Pereira, Perla Cota, Valerie Vandenbempt, Diego Balboa, Anika Böttcher, Natalie Krahmer, Mohammad Lotfollahi, Julie B. Sneddon, Heiko Lickert, Mostafa Bakhti   +21 more
wiley   +1 more source

Lactiplantibacillus Plantarum GUANKE Alleviates Allergic Asthma by Restricting Monocyte‐to‐DC Differentiation Via Microbiota‐Associated IAA

Advanced Science, EarlyView.
Lactiplantibacillus plantarum GUANKE remodels the indigenous gut microbiota and is associated with microbiota‐dependent restoration of circulating IAA. IAA treatment attenuates JAK3‐STAT3 and Jag1‐Notch4‐Hey1 signaling and reduces CX3CR1+Ly6C− monocytic precursor generation and pulmonary CD11b+ DC accumulation, together with reduced Th2 inflammation ...
Yujia He, Jielan Mi, Zhiping Zhao, Xiao Zhang, Zhihan Yang, Kun Yue, Yuanming Huang, Liqiong Song, Xiaoting Wen, Jianguo Xu, Zhihong Ren   +10 more
wiley   +1 more source

Pulmonary Vascular Responses to Serotonin and Effects of Certain Serotonin Antagonists [PDF]

Circulation Research, 1958
Serotonin was the most potent pulmonary vasoconstrictor studied in an experimental preparation in which drugs injected into the pulmonary artery are temporarily excluded from the systemic circulation. Alterations in bronchomotor tone did not approach those produced by acetylcholine.
J C, ROSE, E J, LAZARO
openaire   +2 more sources

Smart Nanotechnologies for Multimodal Neuromodulation and Brain Interfacing

Advanced Science, EarlyView.
Recent advances in smart nanotechnologies are expanding the toolbox for brain interfacing, from wireless neuromodulation and high‐resolution sensing to targeted delivery within the central nervous system. By combining responsive nanomaterials with bioinspired design, these platforms enable multimodal interactions with neurons and glia, while also ...
Tommaso Curiale, Marie Celine Lefevre, Alessio Carmignani, Maria Cristina Ceccarelli, Matteo Battaglini, Attilio Marino, Gianni Ciofani   +6 more
wiley   +1 more source

5-Hydroxytryptamine Receptors and Tardive Dyskinesia in Schizophrenia

Frontiers in Molecular Neuroscience, 2020
BackgroundTardive dyskinesia (TD) is a common side effect of antipsychotic treatment. This movement disorder consists of orofacial and limb-truncal components.
Ivan V. Pozhidaev, Ivan V. Pozhidaev, Diana Z. Paderina, Diana Z. Paderina, Olga Yu. Fedorenko, Olga Yu. Fedorenko, Elena G. Kornetova, Elena G. Kornetova, Arkadiy V. Semke, Anton J. M. Loonen, Anton J. M. Loonen, Nikolay A. Bokhan, Nikolay A. Bokhan, Nikolay A. Bokhan, Bob Wilffert, Bob Wilffert, Svetlana A. Ivanova, Svetlana A. Ivanova, Svetlana A. Ivanova   +18 more
doaj   +1 more source

Review of Gastrointestinal Capsule Robots: Materials, Actuation, Diagnostics, and Therapeutics

Advanced Science, EarlyView.
This review examines gastrointestinal capsule robots through a systems engineering lens, covering shell materials, actuation and localization strategies, diagnostic modalities, therapeutic interventions, and commercialization status. By mapping the complete technological chain from fabrication to clinical deployment, this work identifies critical gaps ...
Zengsheng Li, Zhongguo Ren, Yiliang Lin, Xianfeng Xia, Tianlong Li, Kai Fung Chan, Philip Wai Yan Chiu, Wei Peng Yong, Mengmeng Sun   +8 more
wiley   +1 more source

Effect of a Serotonin Antagonist on Radiation Lethality.

Experimental Biology and Medicine, 1963
SummaryThe serotonin antagonist 1-(N-methyl-piperidyl-4′)-3-phenyl-4-benzyl-pyrazolone-5 (KB-95) shows mildly protective effects against 600 r whole-body X-irradiation in mice, if administered prior to irradiation. The compound exhibits a dose-reduction factor of approximately 1.1 in both rats and mice.
R N, FEINSTEIN, J E, SEAHOLM
openaire   +2 more sources

Vascular effects of serotonin and ischemia

, 1990
Circulating 5-hydroxytryptamine originates in the gastrointestinal tract, where it overflows to the blood; part of that serotonin is taken up and stored by the platelets.
Vanhoutte, PM
core   +1 more source

Neuromorphic Devices and Computing for Sensing, Memory, and Control

Advanced Science, EarlyView.
This review introduces neuromorphic devices made from diverse materials. These devices mimic neuronal functions and architectures and, when integrated with artificial or biological computing, can form closed loops with neurons for pressure, optical, acoustic, and biochemical sensing and modulation.
Zhengguang Zhu, Nicholas Schaffer, Xiao Yang   +2 more
wiley   +1 more source