Results 61 to 70 of about 235,344 (293)

Is the combination of domperidone and metoclopramide increasing the risk of developing serotonin syndrome?: a case report [PDF]

Pediatric Emergency Medicine Journal
Metoclopramide and domperidone are dopamine antagonists that can cause an acute dystonic reaction. Metoclopramide is a rare but major contributor to serotonin syndrome, particularly when used with other serotonergic agents.
Abdullah Nasser Aldosari, Abdullah Alzahrani, Mohammed Alghamdi, Abdulaziz Alzahrani, Abdulraheem Alghamdi   +4 more
doaj   +1 more source

Antagonists of the serotonin receptor 5A target human breast tumor initiating cells

BMC Cancer, 2020
Background Breast tumor initiating cells (BTIC) are stem-like cells that initiate and sustain tumor growth, and drive disease recurrence. Identifying therapies targeting BTIC has been hindered due primarily to their scarcity in tumors.
William D. Gwynne, Mirza S. Shakeel, Adele Girgis-Gabardo, Kwang H. Kim, Emily Ford, Anna Dvorkin-Gheva, Craig Aarts, Methvin Isaac, Rima Al-awar, John A. Hassell   +9 more
doaj   +1 more source

Conformationally Flexible Dimeric-Serotonin-Based Sensitive and Selective Electrochemical Biosensing Strategy for Serotonin Recognition

, 2022
A novel electrochemical sensor was constructed based on an enzyme-mediated physiological reaction between neurotransmitter serotonin per-oxidation to reconstruct dual-molecule 4,4′-dimeric-serotonin self-assembled derivative, and the potential biomedical
Min-Ho Lee (1567513), Sachin Ganpat Chavan (6576569), Ajay Kumar Yagati (1561576), Sangho Yeon (14161108), Taek Lee (1561579), Anna Go (14161105), Aneesh Koyappayil (14161102)   +6 more
core   +1 more source

Carbohydrate‐Mediated Cellular Uptake of Boronic Acid Hybrids In Cellulo and Insulin‐Deficient Zebrafish: Live Imaging and Application of Multiphoton FLIM

Advanced Science, EarlyView.
Boronic acid‐based fluorescent hybrids have been used as part of a versatile platform for real‐time metabolic bioimaging across cellular and organismal scales. Including glucose‐responsive imaging in living cells and in an insulin‐deficient vertebrate model, this work opens new opportunities for the development of precision diagnostics, metabolic ...
Haobo Ge, John S. Fossey, David Gonzalez Calatayud, Stephen E. Flower, Sabrina Wang, Hanna Aitessaid, Melita Tvardauskaite, Julia Dudzic, Max Jewell, Charareh Pourzand, Stanley W. Botchway, David Gurevich, Tony D. James, Sofia I. Pascu   +13 more
wiley   +1 more source

Organic Electrochemical Transistors for Neuromorphic Bioelectronics: Materials and Manufacturing Technologies

Advanced Science, EarlyView.
Organic electrochemical transistors bridge biological ionic signaling and neuromorphic computation through volumetric electrochemical gating. This review connects Organic mixed ionic–electronic conductor materials, device architectures, and manufacturing technologies to show how geometry, ion transport, and fabrication strategies program plasticity ...
Hyunjin Lee, Jihyang Park, Xinyi Wang, Yueqi Deng, Jiashu Ren, Tao Zhou   +5 more
wiley   +1 more source

Serotonergic antagonists and vascular disease

, 1990
5-Hydroxytryptamine (serotonin) can evoke both contraction and relaxation of vascular smooth muscle. In disease, the constrictor component of the response to the monoamine appears to dominate.
Vanhoutte, PM
core   +1 more source

Molecular and pharmacological characterization of serotonin 5-HT2α and 5-HT7 receptors in the salivary glands of the blowfly calliphora vicina [PDF]

, 2012
Secretion in blowfly (Calliphora vicina) salivary glands is stimulated by the biogenic amine serotonin (5-hydroxytryptamine, 5-HT), which activates both inositol 1,4,5-trisphosphate (InsP3)/Ca2+ and cyclic adenosine 3′,5′-monophosphate (cAMP) signalling ...
Walz, Bernd, Bernd Walz, Baumann, Otto, Claudia Röser, Nadine Jordan (120821), Röser,C., Bernd Walz (48845), Wolfgang Blenau, Balfanz, Sabine, Otto Baumann (48844), Blenau, Wolfgang, Baumann, A., Sabine Balfanz (120824), Jordan, Nadine, Baumann, Arnd, Sabine Balfanz, Arnd Baumann, Blenau, Wolfgang (Dr.), Claudia Röser (120818), Wolfgang Blenau (120829), Nadine Jordan, Otto Baumann, Röser, Claudia, Arnd Baumann (120826), Balfanz Sabine, Walz, Bernd (Prof. Dr.), Baumann Otto, Baumann, Otto (PD Dr.), Blenau Wolfgang, Baumann Arnd, Röser Claudia, Jordan Nadine, Walz Bernd   +32 more
core   +1 more source

A Gut‐Brain Axis Underlying Succinate‐Associated Compulsive‐Like Behavior

Advanced Science, EarlyView.
Gut‐derived succinate is associated with an excitatory‐inhibitory imbalance in dmPFC glutamatergic neurons, involving microglial SUCNR1 activation and vagal afferent signaling via upregulated gut 5‐HT4 receptors along the DVC‐CeA‐dmPFC circuit, changes that are linked to excessive compulsive‐like behavior.
Yi Li, Ying‐Dan Zhang, Wei Wang, Xin‐Yi Wu, Di Li, Xin Gong, Fei Tian, Meng‐Yu Dai, Jian Gao, Zi‐Feng Zheng, Zi‐Yang Bi, Dong‐Dong Shi, Zhen Wang   +12 more
wiley   +1 more source

Influence of the descending pain-inhibiting serotonergic pathway on the antihyperalgesic effect of gabapentin in neuropathic pain model rats

Neuroscience Research
Gabapentinoids are used worldwide as first-line agents for the treatment of neuropathic pain. Accumulating evidence indicates that one of the antihyperalgesic mechanisms of gabapentinoids is through activation of the noradrenergic pathway of the ...
Harue Yanagimura, Mika Sasaki, Hiroshi Baba, Yoshinori Kamiya   +3 more
doaj   +1 more source

Serotonin 5-HT6 receptor antagonists for the treatment of cognitive deficiency in Alzheimer's disease

, 2014
Alzheimer’s disease (AD) is one of the most frequent causes of death and disability worldwide and has a significant clinical and socioeconomic impact. In the search for novel therapeutic strategies, serotonin 5-HT6 receptor (5-HT6R) has been proposed as ...
Pardo, Leonardo, Martín-Fontecha Corrales, María Del Mar, López Rodríguez, María Luz, Benhamú Salama, Bellinda, Vázquez Villa, María Del Henar   +4 more
core   +1 more source