Results 21 to 30 of about 1,525,501 (301)

Impact of 5-HT₆ Receptor Subcellular Localization on Its Signaling and Its Pathophysiological Roles

Cells, 2023
The serotonin (5-HT)6 receptor still raises particular interest given its unique spatio-temporal pattern of expression among the serotonin receptor subtypes. It is the only serotonin receptor specifically expressed in the central nervous system, where it
Séverine Chaumont-Dubel, Sonya Galant, Matthieu Prieur, Tristan Bouschet, Joël Bockaert, Philippe Marin   +5 more
doaj   +1 more source

Region specific differential regulation of 5HT-5A and 5B receptor is associated with the difference in stress level between male and female rats

Heliyon, 2022
Stress-related neuropsychiatric disorders affect nearly all people worldwide irrespective of the age and sex of the person. Females are supposed to experience a higher stress and anxiety as compared to the male individuals. The role of serotonin receptor
Sarfraj Ahmad Siddiqui, Sanjay Singh, Atul Rawat, Md Arshad, Sudhir Kumar   +4 more
doaj   +1 more source

Modulation of anxiety by cortical serotonin 1A receptors

Frontiers in Behavioral Neuroscience, 2015
Serotonin (5-HT) plays an important role in the modulation of behavior across animal species. The serotonin 1A receptor (Htr1a) is an inhibitory G-protein coupled receptor that is expressed both on serotonin and non-serotonin neurons in mammals.
Lukasz ePiszczek, Agnieszka ePiszczek, Joanna eKuczmanska, Enrica eAudero, Cornelius T. Gross   +4 more
doaj   +1 more source

Role of serotonin via 5-HT2B receptors in the reinforcing effects of MDMA in mice. [PDF]

PLoS ONE, 2009
The amphetamine derivative 3,4-methylenedioxymethamphetamine (MDMA, ecstasy) reverses dopamine and serotonin transporters to produce efflux of dopamine and serotonin, respectively, in regions of the brain that have been implicated in reward. However, the
Stéphane Doly, Jesus Bertran-Gonzalez, Jacques Callebert, Alexandra Bruneau, Sophie Marie Banas, Arnauld Belmer, Katia Boutourlinsky, Denis Hervé, Jean-Marie Launay, Luc Maroteaux   +9 more
doaj   +1 more source

Expression of Serotonin Receptors in Bone [PDF]

Journal of Biological Chemistry, 2001
The 5-hydroxytryptamine (5-HT) receptors 5-HT(2A), 5-HT(2B), and 5-HT(2C) belong to a subfamily of serotonin receptors. Amino acid and mRNA sequences of these receptors have been published for several species including man. The 5-HT(2) receptors have been reported to act on nervous, muscle, and endothelial tissues.
Westbroek, I., van der Plas, A., de Rooij, K., Klein Nulend, J., Nijweide, P.J.   +4 more
openaire   +5 more sources

Serotonin Receptors: Genetic insights into serotonin function [PDF]

Current Biology, 1995
Targeted disruption of the genes for the 5-HT1B and 5-HT2C serotonin receptors and monoamine oxidase A have confirmed pharmacological experiments and revealed unexpected behavioral roles for serotonin.
Heath, Mark J.S., Hen, René
openaire   +2 more sources

5-hydroxytryptamine (5-HT) cellular sequestration during chronic exposure delays 5-HT₃ receptor resensitization due to Its subsequent release [PDF]

, 2014
The serotonergic synapse is dynamically regulated by serotonin (5-hydroxytryptamine (5-HT)) with elevated levels leading to the down-regulation of the serotonin transporter and a variety of 5-HT receptors, including the 5-HT type-3 (5-HT3) receptors.
Moffat, Christopher, Bollan, Karen A., Connolly, Christopher N., Samson, Andrew J., Alexander, Amy, Hothersall, J. Daniel   +5 more
core   +1 more source

Identification, functional characterization and pharmacological profile of a serotonin type-2b receptor in the medically important insect, Rhodnius prolixus

Frontiers in Neuroscience, 2015
In the Chagas disease vector, Rhodnius prolixus, two diuretic hormones act synergistically to dramatically increase fluid secretion by the Malpighian tubules (MTs) during the rapid diuresis that is initiated upon engorgement of vertebrate blood.
Jean-Paul V Paluzzi, Garima eBhatt, Garima eBhatt, Garima eBhatt, Chang-Hui Jenny Wang, Meet eZandawala, Meet eZandawala, Angela eLange, Angela eLange, Ian eOrchard, Ian eOrchard   +10 more
doaj   +1 more source

Serotonin Receptor and Transporter Endocytosis Is an Important Factor in the Cellular Basis of Depression and Anxiety

Frontiers in Cellular Neuroscience, 2022
Depression and anxiety are common, debilitating psychiatric conditions affecting millions of people throughout the world. Current treatments revolve around selective serotonin reuptake inhibitors (SSRIs), yet these drugs are only moderately effective at ...
Nikita Deo, Gregory Redpath
doaj   +1 more source

Serotonin mediation of early memory formation via 5HT2B receptor-induced glycogenolysis in the day-old chick

Frontiers in Pharmacology, 2014
Investigation of the effects of serotonin on memory formation in the chick revealed an action on at least two 5HT receptors. Serotonin injected intracerebrally produced a biphasic effect on memory consolidation with enhancement at low doses and ...
Marie Elizabeth Gibbs, Leif eHertz
doaj   +1 more source