Results 11 to 20 of about 143,694 (316)

Role of serotonin via 5-HT2B receptors in the reinforcing effects of MDMA in mice. [PDF]

PLoS ONE, 2009
The amphetamine derivative 3,4-methylenedioxymethamphetamine (MDMA, ecstasy) reverses dopamine and serotonin transporters to produce efflux of dopamine and serotonin, respectively, in regions of the brain that have been implicated in reward. However, the
Stéphane Doly, Jesus Bertran-Gonzalez, Jacques Callebert, Alexandra Bruneau, Sophie Marie Banas, Arnauld Belmer, Katia Boutourlinsky, Denis Hervé, Jean-Marie Launay, Luc Maroteaux   +9 more
doaj   +1 more source

Serotonin Receptors: Genetic insights into serotonin function [PDF]

Current Biology, 1995
Targeted disruption of the genes for the 5-HT1B and 5-HT2C serotonin receptors and monoamine oxidase A have confirmed pharmacological experiments and revealed unexpected behavioral roles for serotonin.
Heath, Mark J.S., Hen, René
openaire   +2 more sources

Modulation of anxiety by cortical serotonin 1A receptors

Frontiers in Behavioral Neuroscience, 2015
Serotonin (5-HT) plays an important role in the modulation of behavior across animal species. The serotonin 1A receptor (Htr1a) is an inhibitory G-protein coupled receptor that is expressed both on serotonin and non-serotonin neurons in mammals.
Lukasz ePiszczek, Agnieszka ePiszczek, Joanna eKuczmanska, Enrica eAudero, Cornelius T. Gross   +4 more
doaj   +1 more source

5-hydroxytryptamine (5-HT) cellular sequestration during chronic exposure delays 5-HT₃ receptor resensitization due to Its subsequent release [PDF]

, 2014
The serotonergic synapse is dynamically regulated by serotonin (5-hydroxytryptamine (5-HT)) with elevated levels leading to the down-regulation of the serotonin transporter and a variety of 5-HT receptors, including the 5-HT type-3 (5-HT3) receptors.
Moffat, Christopher, Bollan, Karen A., Connolly, Christopher N., Samson, Andrew J., Alexander, Amy, Hothersall, J. Daniel   +5 more
core   +1 more source

Serotonin Receptor and Transporter Endocytosis Is an Important Factor in the Cellular Basis of Depression and Anxiety

Frontiers in Cellular Neuroscience, 2022
Depression and anxiety are common, debilitating psychiatric conditions affecting millions of people throughout the world. Current treatments revolve around selective serotonin reuptake inhibitors (SSRIs), yet these drugs are only moderately effective at ...
Nikita Deo, Gregory Redpath
doaj   +1 more source

Identification, functional characterization and pharmacological profile of a serotonin type-2b receptor in the medically important insect, Rhodnius prolixus

Frontiers in Neuroscience, 2015
In the Chagas disease vector, Rhodnius prolixus, two diuretic hormones act synergistically to dramatically increase fluid secretion by the Malpighian tubules (MTs) during the rapid diuresis that is initiated upon engorgement of vertebrate blood.
Jean-Paul V Paluzzi, Garima eBhatt, Garima eBhatt, Garima eBhatt, Chang-Hui Jenny Wang, Meet eZandawala, Meet eZandawala, Angela eLange, Angela eLange, Ian eOrchard, Ian eOrchard   +10 more
doaj   +1 more source

Enhanced sensitivity of postsynaptic serotonin-1A receptors in rats and mice with high trait aggression [PDF]

, 2001
Individual differences in aggressive behaviour have been linked to variability in central serotonergic activity, both in humans and animals. A previous experiment in mice, selectively bred for high or low levels of aggression, showed an up-regulation of ...
Buwalda, Bauke, Vegt, Bea J. van der,, van der Vegt, BJ, Ruiter, Anne J.H. de,, Jong, Jelly G. de,, Koolhaas, J.M., de Ruiter, Anne J.H., Bauke Buwalda, Sietse F de Boer, Koolhaas, Jaap M.,, van der Vegt, Bea J., de Jong, Jelly G., Koolhaas, JM, de Boer, SF, de Jong, JG, Buwalda, Bauke,, Buwalda, B, Bea J van der Vegt, Boer, Sietse F. de,, Anne J.H de Ruiter, Jelly G de Jong, de Boer, Sietse F., Jaap M Koolhaas, de Ruiter, AJH   +23 more
core   +1 more source

A physiologic role for serotonergic transmission in adult rat taste buds. [PDF]

PLoS ONE, 2014
Of the multiple neurotransmitters and neuropeptides expressed in the mammalian taste bud, serotonin remains both the most studied and least understood.
Luc Jaber, Fang-li Zhao, Tamara Kolli, Scott Herness   +3 more
doaj   +1 more source

Serotonin mediation of early memory formation via 5HT2B receptor-induced glycogenolysis in the day-old chick

Frontiers in Pharmacology, 2014
Investigation of the effects of serotonin on memory formation in the chick revealed an action on at least two 5HT receptors. Serotonin injected intracerebrally produced a biphasic effect on memory consolidation with enhancement at low doses and ...
Marie Elizabeth Gibbs, Leif eHertz
doaj   +1 more source

The effects of glycogen synthase kinase-3beta in serotonin neurons. [PDF]

PLoS ONE, 2012
Glycogen synthase kinase-3 (GSK3) is a constitutively active protein kinase in brain. Increasing evidence has shown that GSK3 acts as a modulator in the serotonin neurotransmission system, including direct interaction with serotonin 1B (5-HT1B) receptors
Wenjun Zhou, Ligong Chen, Jodi Paul, Sufen Yang, Fuzeng Li, Karen Sampson, Jim R Woodgett, Jean Martin Beaulieu, Karen L Gamble, Xiaohua Li   +9 more
doaj   +1 more source