Results 181 to 190 of about 207,072 (360)

Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for CYP2D6 Genotype and Use of 5‐HT3 Receptor Antagonists: 2026 Update

Clinical Pharmacology &Therapeutics, EarlyView.
5‐hydroxytryptamine type 3 (5‐HT3) receptor antagonists are used to treat nausea and vomiting and in the prevention of chemotherapy‐induced, radiation‐induced, and postoperative nausea and vomiting. Most of the 5‐HT3 receptor antagonists (i.e., ondansetron, tropisetron, dolasetron, palonosetron, and ramosetron) are metabolized by CYP2D6, but the extent
Claire Moore, Melissa S. Bourque, Andreas Halman, José A. G. Agúndez, Cynthia A. Prows, Keiko Hikino, Matthias Schwab, Carolyn J. Oxencis, Dharmisha Chauhan, Meta H.M. Diekstra, Susie E. Long, Gillian C. Bell, Andrea Gaedigk, Michelle Whirl‐Carrillo, Teri E. Klein, Kelly E. Caudle, Rachel Conyers   +16 more
wiley   +1 more source

Serotonin Receptors as Therapeutic Targets for Autism Spectrum Disorder Treatment. [PDF]

Int J Mol Sci, 2022
Lee A, Choo H, Jeon B.
europepmc   +1 more source

(3-Phenylsulfonylcycloalkano[eandd]pyrazolo[1,5-a]pyrimidin-2-yl)amines: Potent and Selective Antagonists of the Serotonin 5-HT₆Receptor

, 2010
Alexandre V. Ivachtchenko, Dmitri E. Dmitriev, Elena S. Golovina, M. Г. Кадиева, Angela G. Koryakova, Volodymyr Kysil, Oleg D. Mitkin, Ilya Okun, Sergey E. Tkachenko, Anton A. Vorobiev   +9 more
openalex   +1 more source

Registered Clinical Trials of Ayahuasca and DMT: A Scoping Review

Clinical Pharmacology &Therapeutics, EarlyView.
Interest in ayahuasca and its main component, N,N‐Dimethyltryptamine (DMT), has currently moved from historical and experimental use into modern clinical development. Yet, current evidence is fragmented, and systematic mapping of trial methods and design choices remains limited.
Tijana Stojanović, Kent W. Nilsson, Robert Fredriksson, Helgi B. Schiöth, Thiago C. Moulin   +4 more
wiley   +1 more source

Ergotamine Stimulates Human 5-HT₄-Serotonin Receptors and Human H₂-Histamine Receptors in the Heart. [PDF]

Int J Mol Sci, 2023
Jacob H, Braekow P, Schwarz R, Höhm C, Kirchhefer U, Hofmann B, Neumann J, Gergs U.   +7 more
europepmc   +1 more source

Neither the 5-HT1A- nor the 5-HT2-Receptor Subtype Mediates the Effect of Fluvoxamine, a Selective Serotonin Reuptake Inhibitor, on Forced-Swimming-Induced Immobility in Mice

, 1995
Takashi Egawa, Yasuyuki Ichimaru, Taiichiro Imanishi, Aiko Sawa   +3 more
openalex   +1 more source

Caveolin-1 interacts with 5-HT2A serotonin receptors and profoundly modulates the signaling of selected Gαq-coupled protein receptors

, 2020
B. Compton-Toth, B.L. Roth, A. Bhatnagar, D.J. Sheffler, W.K. Kroeze   +4 more
openalex   +1 more source

Identification of the 5-HT1A serotonin receptor as a novel therapeutic target in a C. elegans model of Machado-Joseph disease

, 2021
Joana Pereira‐Sousa, Bruna Ferreira-Lomba, Aina Bellver‐Sanchís, Daniela Vilasboas‐Campos, Jorge H. Fernandes, Marta D. Costa, Mark A. Varney, Adrian Newman‐Tancredi, Patrı́cia Maciel, Andreia Teixeira‐Castro   +9 more
openalex   +1 more source

The binding of palonosetron and other antiemetic drugs to the serotonin 5-HT3 receptor [PDF]

, 2020
Eleftherios Zarkadas, Hong Zhang, Wensheng Cai, Grégory Effantin, Jonathan Perot, Jacques Neyton, Christophe Chipot, Guy Schoehn, François Dehez, Hugues Nury   +9 more
openalex   +1 more source

Impact of CYP2C19 and CYP3A4 Inhibitor Use on Clopidogrel Clinical Effectiveness in CYP2C19 Genotyped Patients Undergoing Percutaneous Coronary Intervention

Clinical Pharmacology &Therapeutics, EarlyView.
CYP2C19 and CYP3A4 contribute to clopidogrel bioactivation. CYP2C19 no‐function alleles diminish clopidogrel's antiplatelet effects and clinical effectiveness. Coadministration of either a CYP2C19 or a CYP3A4 inhibitor may also reduce clopidogrel's antiplatelet effects and lead to phenoconversion in patients without a CYP2C19 no‐function allele (normal/
Danwei Shao, Jean G. Malavé, Joseph S. Rossi, Francesco Franchi, Ellen C. Keeley, Dominick J. Angiolillo, George A. Stouffer, Larisa H. Cavallari, Craig R. Lee   +8 more
wiley   +1 more source