Results 181 to 190 of about 708,936 (290)

The gut microbiome and drug‐resistant epilepsy: Microbiome–antiseizure medication interactions and implications for pharmacoresistance

Epilepsia Open, EarlyView.
Abstract Drug‐resistant epilepsy (DRE) affects approximately one‐third of patients with epilepsy and represents a major unmet clinical need. While traditional hypotheses of pharmacoresistance have focused on alterations in drug targets, efflux transporter overexpression, and intrinsic disease severity, the gut microbiome has recently emerged as a ...
Khaled Zammar, Majd A. AbuAlrob, Musab Ali, Simona Lattanzi, Boulenouar Mesraoua   +4 more
wiley   +1 more source

Structure of serotonin receptors: molecular underpinning of receptor activation and modulation. [PDF]

Signal Transduct Target Ther, 2021
Zweckstetter M, Dityatev A, Ponimaskin E.   +2 more
europepmc   +1 more source

Efficacy and safety of fenfluramine in Dravet syndrome: The impact of patient clinical characteristics

Epilepsia Open, EarlyView.
This graphical abstract provides an overview of the content from this post hoc analysis evaluating the efficacy and safety of fenfluramine in patients with Dravet syndrome stratified by age, number of previously attempted antiseizure medications, and SCN1A pathogenic variant status using data pooled from the three pivotal randomized controlled trials ...
Rima Nabbout, Joseph Sullivan, Stéphane Auvin, J. Helen Cross, Orrin Devinsky, Antonio Gil‐Nagel, Renzo Guerrini, Kelly G. Knupp, M. Scott Perry, Rocío Sánchez‐Carpintero, An‐Sofie Schoonjans, Ingrid E. Scheffer, Nicola Specchio, Adam Strzelczyk, James Wheless, Elaine C. Wirrell, Diego Morita, Patrick Healy, Mélanie Langlois, Amélie Lothe, Lieven Lagae   +20 more
wiley   +1 more source

Tegaserod Stimulates 5-HT₄ Serotonin Receptors in the Isolated Human Atrium. [PDF]

Int J Mol Sci
Hesse C, Neumann J, Compan V, Ponimaskin E, Müller FE, Hofmann B, Gergs U.   +6 more
europepmc   +1 more source

Resumption of Menses and Normalisation of Body Weight in Adolescents Undergoing Specialised Treatment for Anorexia Nervosa Inpatient or Outpatient Treatment

European Eating Disorders Review, EarlyView.
ABSTRACT Objective To predict resumption of menses (ROM) in patients with anorexia nervosa (AN). Method Females aged 9–17 years with AN, receiving inpatient multimodal treatment (IMT) or family‐based treatment (FBT) underwent assessments at baseline, 6‐month and 12‐month follow‐up (12FU).
Annika Woltmann, Linus Imken, Vivien Kaiser, Johanna L. Keeler, Daniel Le Grange, Christoph U. Correll, Verena Haas   +6 more
wiley   +1 more source

Network control energy reductions under DMT relate to serotonin receptors, signal diversity, and subjective experience. [PDF]

Commun Biol
Singleton SP, Timmermann C, Luppi AI, Eckernäs E, Roseman L, Carhart-Harris RL, Kuceyeski A.   +6 more
europepmc   +1 more source

Psychopharmacological Prescribing Patterns Among Italian Adolescents With Anorexia Nervosa: Exploring Real‐World Treatment Practices

European Eating Disorders Review, EarlyView.
ABSTRACT Objective To investigate real‐world psychopharmacological prescribing patterns among Italian adolescents with anorexia nervosa (AN) compared with psychiatric controls without eating disorders, and to examine whether AN diagnosis independently predicts medication use after accounting for psychiatric comorbidities.
Marika Orlandi, Arianna Vecchio, Giulia Andorno, Maria Pia Riccio, Cinzia Crispino, Martina Maria Mensi   +5 more
wiley   +1 more source

Psilocybin Facilitates Fear Extinction: Importance of Dose, Context, and Serotonin Receptors. [PDF]

ACS Chem Neurosci
Woodburn SC, Levitt CM, Koester AM, Kwan AC.   +3 more
europepmc   +1 more source

Rewiring nutrition: Chemical insights into the physiological and microbiological roles of food's microconstituents

Food Biomacromolecules, EarlyView.
Bidirectional interactions between food‐derived sensory compounds, gut sensing and microbiota, host physiological feedback, and metabolite production within the food matrix collectively shape sensory perception, microbial dynamics, and metabolic health.
Mohammad Nazrul Islam Bhuiyan
wiley   +1 more source