Results 131 to 140 of about 709,580 (281)

Linezolid induced Serotonin Syndrome in the absence of serotonergic agent

Asian Journal of Medical Sciences, 2018
Robin George Manappallil , Aryasree Kakkattil   +1 more
doaj   +1 more source

Effects of Glyphosate and Glyphosate‐Based Herbicides on the Mammalian Gut Microbiome: A Critical Review

Journal of Applied Toxicology, EarlyView.
ABSTRACT Glyphosate has long been considered to pose negligible direct risk to mammals on the grounds that its molecular target, 5‐enolpyruvylshikimate‐3‐phosphate synthase (EPSPS), of the shikimate pathway, is absent from animal cells. This rationale is inaccurate as a complete toxicological argument, because the shikimate pathway is present in some ...
Robin Mesnage
wiley   +1 more source

When Tics and Autism Meet: Phenomenology, Severity, and Treatment Patterns

Movement Disorders Clinical Practice, EarlyView.
ABSTRACT Background Tic disorders frequently co‐occur with neurodevelopmental conditions, including autism spectrum disorder (ASD). However, the impact of ASD on tic phenomenology, severity, and treatment patterns remains incompletely understood. Objectives To compare clinical characteristics, tic phenomenology, severity, and treatment patterns in ...
Fatimah Aldurayhim, Davide Martino, Justyna R. Sarna, Tamara Pringsheim   +3 more
wiley   +1 more source

Altered Cerebrospinal Fluid Tryptophan–Kynurenine Pathway Metabolism in Multiple System Atrophy

Movement Disorders, EarlyView.
Abstract Background Alterations in tryptophan–kynurenine (TRP‐KYN) metabolism, which is associated with neuroinflammation, remain unclear in multiple system atrophy (MSA). Objective The aim was to investigate cerebrospinal fluid (CSF) TRP metabolites in MSA and their associations with other biomarkers.
Ryunosuke Nagao, Kazuya Kawabata, Yasuaki Mizutani, Sayuri Shima, Akihiro Ueda, Mizuki Ito, Yasuhiro Maeda, Akihiro Mouri, Hirohisa Watanabe   +8 more
wiley   +1 more source

In Response to Borgsteede et al. About Bupropion and Serotonin Toxicity. [PDF]

J Med Toxicol, 2020
Murray BP, Carpenter J, Moran TP, Calello DP, Kazzi Z.   +4 more
europepmc   +1 more source

COVID‐19 Amplifies Sex‐Specific Dopamine and Glial Responses in a Parkinson's Disease Mouse Model

Movement Disorders, EarlyView.
Abstract Background Exposure to environmental agents, including viral infections, may increase Parkinson's disease (PD) susceptibility, especially in males, but the neurodegenerative risk extent of COVID‐19 remains uncertain. Objectives We investigated the plausible link between severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) infection and
Ifeoluwa Awogbindin, Mélanie Bourque, Marc Morissette, Marie‐Ève Hamelin, Chantal Rhéaume, Jared VanderZwaag, Antonia Landwehr, Disha Patel, Guy Boivin, Marie‐Ève Tremblay, Thérèse Di Paolo   +10 more
wiley   +1 more source

No Causal Relation Between Bupropion in Therapeutic Dose and Serotonin Toxicity. [PDF]

J Med Toxicol, 2020
Borgsteede SD, Birkenhager TK, Zaal RJ, Alsma J.   +3 more
europepmc   +1 more source

Artificial Intelligence‐Driven Natural Product Drug Discovery: From Computational Genome Mining to Clinical Translation

Medicinal Research Reviews, EarlyView.
ABSTRACT Natural products (NPs) have historically yielded numerous therapeutic agents, yet their integration into modern drug discovery has been constrained by chemical complexity, low abundance, laborious dereplication, and limited target annotation.
Antonio Lavecchia
wiley   +1 more source

Repurposing antimicrobial agents for neuroprotection: Mechanisms, clinical potential, and challenges

Neuroprotection, EarlyView.
Antimicrobial agents exert neuroprotective effects through modulation of interconnected pathways. Tetracyclines, macrolides, antimalarial agents, sulfones, and antiparasitic agents suppress neuroinflammation, oxidative stress, and apoptosis while preserving mitochondrial function and neurotransmission.
Mohammad Amin Manavi, Mohammadreza Salehi, Razieh Mohammad Jafari, Ramin Goudarzi, Saman Khosravi, Ahmad Reza Dehpour   +5 more
wiley   +1 more source

Single-Agent Bupropion Exposures: Clinical Characteristics and an Atypical Cause of Serotonin Toxicity. [PDF]

J Med Toxicol, 2020
Murray B, Carpenter J, Dunkley C, Moran TP, Kiernan EA, Rianprakaisang T, Alsukaiti WS, Calello DP, Kazzi Z, Toxicology Investigators Consortium (ToxIC).   +9 more
europepmc   +1 more source