Results 171 to 180 of about 267,093 (291)

QSAR-Guided Design of Serotonin Transporter Inhibitors Supported by Molecular Docking and Biased Molecular Dynamics. [PDF]

Pharmaceuticals (Basel)
Veselinović AM, Culletta G, Živković JV, Sunarić S, Mitić Ž, Roomi MS, Tutone M.   +6 more
europepmc   +1 more source

Cholinergic inputs to motoneurons in the spinal cord augment focal muscle spasticity in rodents

British Journal of Pharmacology, EarlyView.
Background and Purpose Cholinergic premotor inputs to motoneurons support high levels of motor output when required. However, the possible role of these inputs in pathologically elevated muscle tone has not been characterised. To address this, we examined the modulatory effect of spinal acetylcholine (ACh) on experimental spastic paralysis ...
Patrik Meglić, Petra Šoštarić, Eirini Tsape, Melpomeni Galani, Ana Knezović, Laura Restani, Marco Pirazzini, Ornella Rossetto, Gareth B. Miles, Laskaro Zagoraiou, Ivica Matak   +10 more
wiley   +1 more source

Serotonin transporter SERT: a novel immune checkpoint for CD8⁺ T cell antitumor therapy. [PDF]

J Immunother Cancer
Xiao Q, Zhang X, Liang X, Yu G, Li Y, Du R, Xiang H, Yang Z, Liu Y.   +8 more
europepmc   +1 more source

Iloperidone treatment mitigates the Juvenile Huntington's Disease phenotype possibly via Sigma‐1 Receptor Modulation

The FEBS Journal, EarlyView.
We investigated the potential of iloperidone as an activator of Sigma‐1 receptor (S1R) neuroprotective function in juvenile Huntington's disease (jHD). We tested iloperidone on cortical neurons differentiated from patient‐derived iPSCs, demonstrating that it acts as a S1R agonist, decreasing apoptosis, huntingtin aggregation, and oxidative stress ...
Ersilia Fornetti, Gaia Galluzzi, Mario Frezzini, Cécile Exertier, Vittorio Brufani, Gianni Colotti, Giancarlo Ruocco, Jessica Rosati, Angelo Luigi Vescovi, Daniele Narzi, Ilaria Genovese, Andrea Ilari   +11 more
wiley   +1 more source

Maternal serum serotonin, serotonin transporter, and umbilical cord arterial serotonin levels in obese versus non-obese pregnancies. [PDF]

North Clin Istanb
Rahman SA, Yusrawati.
europepmc   +1 more source

CD36‐mediated lipid rewiring in the metabolic adaptation of tumour ecosystems

The FEBS Journal, EarlyView.
Nutrient deprivation drives a lipid‐centric shift in tumour metabolic symbiosis and signalling network. CD36 functions as a bidirectional bridge, transferring fatty acids from stromal donors (adipocytes, CAFs) to the ecosystem tumour‐ and microenvironment‐dependently.
Anna Sebestyén, Viktória Varga, Fatime Szalai, Risa Miyaura, Nóra Förhécz, Bálint Csikós, Rebeka Gelencsér, Zsófia Gábriel, Timea Komlódi, Katalin Dezső, Ildikó Krencz, Dorottya Moldvai   +11 more
wiley   +1 more source

Pharmacological Evaluation of Tropane Analogues at the Serotonin Transporter. [PDF]

ACS Chem Neurosci
Avanes AA, Warren HT, Senthil A, Olson DE.   +3 more
europepmc   +1 more source

Nutrient‐specific combinatorial secretion of GLP‐1 and neurotransmitters in the enteroendocrine L‐cell line GLUTag

The FEBS Journal, EarlyView.
Enteroendocrine L cells function as chemosensors in the intestine. Using the L‐cell line GLUTag, we show that distinct nutrients trigger different combinations of co‐secretion of GLP‐1 and neurotransmitters: D‐glucose evokes GLP‐1, glutamate, and ATP; L‐glutamine evokes GLP‐1 and glutamate; sucralose and butyrate evoke only GLP‐1.
Yo Ito, Kazuki Harada, Yuri Osuga‐Yoshiike, Masami Yokota Hirai, Tetsuya Kitaguchi, Takashi Tsuboi   +5 more
wiley   +1 more source

Structural basis of vilazodone dual binding mode to the serotonin transporter. [PDF]

Nat Commun
Kalenderoglou IE, Nygaard A, Vogt CD, Turaev A, Pape T, Adams NBP, Newman AH, Loland CJ.   +7 more
europepmc   +1 more source

Pharmacological Evaluation of Plant Alkaloid Analogs at the Serotonin Transporter

Serotonin transporter (SERT) modulators have played a critical role as therapeutic agents for the treatment of depression, anxiety, addiction, and post-traumatic stress disorder (PTSD), among many other conditions.
Avanes, Arabo Andre
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