Results 151 to 160 of about 2,926,392 (292)

Time‐Resolved Multi‐Omics Identify Biomarkers of Immediate Reactions to mRNA Vaccination

Allergy, EarlyView.
We compared early vaccine‐induced immune and metabolic signatures and downstream immunity after second and booster BNT162b2 doses in participants with sARs, ISSRs, or no reactions. Neutrophil mobilization, antiviral programs, and robust anti‐S‐antibody responses occurred across reaction groups.
Ana Olivera, Benjamin Schwarz, Brittany Dulek, Ian S. LaCroix, Min Li, Lindsay Chatman, Muhammad B. Khalid, Ellen Zektser, Karen Laky, Stella Hartono, Eric Bohrnsen, Cole D. Kimzey, Eric Chu, Roa Harb, Pamela A. Frischmeyer‐Guerrerio   +14 more
wiley   +1 more source

The Origins of Allergy: An Outside‐In, Bioenergetic Hypothesis

Allergy, EarlyView.
ABSTRACT Allergic disease has risen too rapidly for inherited susceptibility to explain it, and the risk variants so far reported lie in the epithelial barrier and in type‐2 immunity. We propose a five‐layer model in which epithelial barrier and bioenergetic dysfunction may precede and promote type‐2 immune deviation rather than arise solely as its ...
Peter K. Smith, Nicholas P. West, Stanley Du Preez, Hugh A. Sampson, Peter W. Hellings, David Price, Liam O'Mahony, Carina Venter, Cezmi A. Akdis, Gil Yosipovitch   +9 more
wiley   +1 more source

Serotonin Transporter Gene Polymorphism and its Relationship to Plasma Serotonin in Irritable Bowel Syndrome [PDF]

, 2004
Background/Aims: Serotonin is an important mediator of intestinal peristalsis and it undergoes reuptake by a transporter protein (SERT). It has been reported that polymorphisms in the promoter for synthesis of SERT (SERT-P) influence the response to a ...
지상원, 김영균, 박효진, 이상인   +3 more
core  

Effect of Testosterone Treatment on Leucocyte Telomere Length in Men: Results From a Randomised Placebo‐Controlled Trial

Andrology, EarlyView.
ABSTRACT Background Lower testosterone concentrations in older men are associated with poorer health outcomes. Objective We examined whether, on a background of lifestyle intervention, testosterone treatment modulates leucocyte telomere length, a postulated marker of biological ageing, in overweight men with impaired glucose tolerance (IGT) or newly ...
Bu B. Yeap, Jennie Hui, Kristy P. Robledo, Gillian Arscott, Mathis Grossmann, David J. Handelsman, Warrick J. Inder, Bronwyn G. A. Stuckey, Alicia J. Jenkins, Karen Bracken, John P. Beilby, Gary A. Wittert   +11 more
wiley   +1 more source

Developmental roles of the serotonin transporter

, 2010
From invertebrates to humans, serotonin (5-HT) exerts structural effects especially during development. The 5-HT transporter (SERT) directly regulates these effects by maintaining extracellular 5-HT concentrations within a physiological range and ...
Persico A. M.
core  

Effects of Immediate Skin‐to‐Skin Contact in Preterm Infants in High‐Resource Settings: A Systematic Review

Acta Paediatrica, EarlyView.
ABSTRACT Aim A landmark trial published in 2021 demonstrated a 25% reduction in neonatal mortality when comparing immediate skin‐to‐skin contact (iSSC) to conventional care in infants with birthweight 1–1.8 kg in low‐ and middle‐resource settings.
Victoria Rettedal, Siren Rettedal, Maren Johanne Heilskov Rytter, Linea Grothe Larsen, Frederikke Buskov, Evalotte Mörelius, Katrin Mehler, Karoline Lode‐Kolz   +7 more
wiley   +1 more source

Serotonin transporter gene polymorphisms and platelet [3H] paroxetine binding in premenstrual dysphoria

, 2003
The purpose of this study was to investigate if women with premenstrual dysphoria differ from controls with respect to the number of platelet serotonin transporters, and with respect to three polymorphisms in the gene coding for the serotonin transporter:
Westberg, Lars,, Landén, Mikael,, Rosmond, Roland,, Sundblad-Elverfors, Charlotta,, Ekman, Agneta,, Baghaei, Fariba,, Melke, Jonas,, Eriksson, O, Eriksson, Elias,   +8 more
core  

Cancer pain: current practice and emerging targets

British Journal of Pharmacology, EarlyView.
Cancer pain (CP) arises from a complex interplay between the tumour and its microenvironment. Many patients experience a mixed pain phenotype that encompasses nociceptive, neuropathic and neuroinflammatory mechanisms, and vary across tumour type and disease stage. Despite decades of intensive research, the mainstay of cancer pain treatment is still non‐
Yi Ye, Marcin Chwistek, Zhiting Gong, Vanessa Uzonwanne, Xiaojie Shi, Arpad Szallasi   +5 more
wiley   +1 more source

In silico prediction of novel effective combinational treatment of chronic pain in individual patients: A joint white paper of the H2020 QSPainRelief consortium

British Journal of Pharmacology, EarlyView.
Abstract Opioids are prescribed widely for chronic pain despite well‐recognised risks and variable long‐term benefit, reflecting the lack of effective alternatives for many patients. Combination therapies offer a promising strategy to enhance efficacy whilst reducing side effects.
André Mouraux, Solenn Gousset, Beltrán Alvarez, Monica Baiula, Wouter Bakker, Andrea Bedini, Monir Bertayli, Divakar Budda, Robert Carr, Elisabetta Cuna, Óscar Díaz, Nina Donner, Jesús Giraldo, Geert‐Jan Groeneveld, Berfin Gülave, David Guydan, Hemme Hijma, Rafael Maldonado, Pedro Renault, Carlos Rinaudo, Jeroen Elaissaiss‐Schaap, Athan Spiros, Sara Stoeber, Petri Takkala, Daan van Valkengoed, Coen van Hasselt, Elizabeth (Liesbeth) C.M. de Lange   +26 more
wiley   +1 more source

Childhood maltreatment, serotonin transporter gene, and risk for callous and unemotional traits: A prospective investigation. [PDF]

Psychiatry Res, 2020
Widom CS, Miller D, Li X, Gordon D, Brzustowicz L.   +4 more
europepmc   +1 more source