Results 161 to 170 of about 2,926,392 (292)

Volume of Amygdala Subregions and Plasma Levels of Brain-Derived Neurotrophic Factor and Cortisol in Patients with s/s Genotype of Serotonin Transporter Gene Polymorphism of First-Episode and Drug-Naive Major Depressive Disorder: An Exploratory Study. [PDF]

Neurol Int, 2022
Okamoto N, Watanabe K, Tesen H, Ikenouchi A, Igata R, Konishi Y, Natsuyama T, Fujii R, Kakeda S, Kishi T, Iwata N, Yoshimura R.   +11 more
europepmc   +1 more source

Effects of lifelong sulforaphane intake on behavioural, neurochemical and biomolecular dysfunctions in the BTBR T+ Itpr3tf/J mouse model of autism spectrum disorders

British Journal of Pharmacology, EarlyView.
Created in BioRender. Schiavone, S. (2026). https://BioRender.com/cy0xq6z. Abstract Background and Purpose Autism spectrum disorders (ASD) are multifactorial neurodevelopmental conditions associated with oxidative stress and neuroinflammation across critical developmental periods.
Vladyslav Sikora, Maria Bove, Lisa Pia Agosti, Rossella Pia Palmieri, Mohsin Zafar, Paolo Tucci, Maria Grazia Morgese, Stefania Schiavone, Luigia Trabace   +8 more
wiley   +1 more source

Crossing subfamily borders: Mechanosensitive TREK‐1 and alkaline‐activated TASK‐4 form heterodimers with unique functional and pharmacological properties

British Journal of Pharmacology, EarlyView.
Background and Purpose The tandem of two‐pore‐domain potassium (K2P) channels TREK‐1 and TASK‐4 are expressed in the heart and pancreatic beta‐cells. As TREK‐1 and TASK‐4 belong to distinct subfamilies with different functional hallmarks, heteromerization of these two channels was highly unexpected.
Sven Schütte, Florian Schick, Emilia De Martino, Hannah Schmitz, Katharina E. S. Zander, Franziska Holz, Patrick Sauer, Luise Mildeberger, Moritz Linder, Axel Loewe, Aytug K. Kiper, Silke Kauferstein, Martin K.‐H. Schäfer, Susanne Rinné, Niels Decher   +14 more
wiley   +1 more source

Investigation of the mechanisms and modulation of irinotecan‐induced emesis in Suncus murinus

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Irinotecan is a widely used chemotherapeutic agent that frequently causes nausea and emesis. Its emetic mechanism of action is poorly understood and the choice of drugs to reduce nausea and emesis is largely empirical. Experimental Approach Using Suncus murinus, we examined (i) the dose–response and temporal profile of ...
Zengbing Lu, Julia Y. H. Liu, Yasuhiro Nakagami, Zitong Li, Xiaofei Huang, Man P. Ngan, Dexuan Cui, John A. Rudd   +7 more
wiley   +1 more source

Prenatal exposure to environmental air pollution and psychosocial stress jointly contribute to the epigenetic regulation of the serotonin transporter gene in newborns

, 2023
Provenzi L, Nazzari S, Cagliero L, Grumi S, Pisoni E, Mallucci G, Bergamaschi R, Maccarini J, Giorda R.   +8 more
europepmc   +1 more source

Emerging insights into amino acid metabolism in the heart: implications for cardiovascular diseases and therapeutic targeting

British Journal of Pharmacology, EarlyView.
As a metabolically versatile organ, the heart is capable of generating energy from a wide range of substrates. Although fatty acid and glucose metabolism in the heart have been extensively studied, the contribution of amino acid metabolism to cardiac physiology and disease is gaining increasing attention.
Tayyiba Azam, Hongyuan Zhang, Min Zi, Chen Chen, Junfang Wu, Andreas Papapetropoulos, Xin Wang   +6 more
wiley   +1 more source

Features of connectivity of default mode network depending on polymorphism of serotonin transporter gene (5-HTTLPR). [PDF]

Vavilovskii Zhurnal Genet Selektsii
Bocharov AV, Savostyanov AN, Tamozhnikov SS, Saprygin AE, Lebedkin DA, Merkulova EA, Knyazev GG.   +6 more
europepmc   +1 more source

Cholinergic inputs to motoneurons in the spinal cord augment focal muscle spasticity in rodents

British Journal of Pharmacology, EarlyView.
Background and Purpose Cholinergic premotor inputs to motoneurons support high levels of motor output when required. However, the possible role of these inputs in pathologically elevated muscle tone has not been characterised. To address this, we examined the modulatory effect of spinal acetylcholine (ACh) on experimental spastic paralysis ...
Patrik Meglić, Petra Šoštarić, Eirini Tsape, Melpomeni Galani, Ana Knezović, Laura Restani, Marco Pirazzini, Ornella Rossetto, Gareth B. Miles, Laskaro Zagoraiou, Ivica Matak   +10 more
wiley   +1 more source

Association Study on Multi-Timepoint DNA Methylation Levels of Serotonin Transporter Gene and Adolescent Psychological-Behavioral Development. [PDF]

Neuropsychopharmacol Rep
Ikegame T, Bundo M, Nagaoka D, Yanagida Y, Nakachi Y, Kiyota E, Okada N, Koike S, Yamasaki S, Ando S, Nishida A, Iwamoto K, Kasai K.   +12 more
europepmc   +1 more source

The serotonin transporter gene polymorphism (SLC6A4) and risk for psychiatric morbidity and comorbidity in the Baltimore ECA follow-up study. [PDF]

Compr Psychiatry, 2020
Miozzo R, Eaton WW, Joseph Bienvenu O, Samuels J, Nestadt G.   +4 more
europepmc   +1 more source