Results 221 to 230 of about 2,926,392 (292)

Plasma Lipidomic Features of Adolescent Major Depressive Disorder and Lipid Changes After Fluoxetine Treatment

CNS Neuroscience &Therapeutics, Volume 32, Issue 11, November 2026.
Dysregulated plasma lipid homeostasis with aberrant triglycerides, lysophospholipids, and membrane sphingolipids represents a core pathological feature of adolescent major depressive disorder. Eight‐week fluoxetine treatment remodels lipid profiles including bile acid metabolites and modulates key signaling pathways, supporting novel lipid‐based ...
Chenxi Liu, Yao Li, Hanchen Hou, Jiamei Guo, Bingjie Qin, Xiaoxia Xu, Yuqian He, Tingting Lei, Fei Chen, Lige Zhang, Quanbing Liu, Li Gao, Jiaqi Shi, Haoran Xing, Teng Teng, Tian Qiu, Xinyu Zhou   +16 more
wiley   +1 more source

Association between polymorphisms in the serotonin transporter gene-linked polymorphic region and risk for irritable bowel syndrome in China: evidence based on a meta-analysis. [PDF]

J Int Med Res, 2019
Jia Z, Wang L, Yu B, Li Q, Dong X.
europepmc   +1 more source

Advances in Multidimensional Molecular Mechanisms of Epilepsy and Precision Therapy Strategies

CNS Neuroscience &Therapeutics, Volume 32, Issue 11, November 2026.
Epilepsy arises from a multidimensional network imbalance, integrating genetic, inflammatory, and metabolic disruptions. This complexity drives neuronal hyperexcitability and underpins therapeutic challenges. Our review highlights how emerging precision strategies, from targeted molecular therapies to neuromodulation, offer a transformative path toward
Yimin Han, Jingxuan Xu, Yuntian Shen, Jitai Zhang, Xia Li, Xinlei Yao, Lei Qi, Hualin Sun   +7 more
wiley   +1 more source

Pediatric Developmental Safety Assessment and New Approach Methodologies: US FDA/Triangle CERSI Workshop Report

Clinical Pharmacology &Therapeutics, Volume 120, Issue 5, Page 1240-1249, November 2026.
Pediatric developmental safety assessment presents distinct challenges in drug development. Children undergo dynamic changes in organ systems and drug disposition pathways during development, and drug‐related effects may be delayed or manifested differently than in adults.
Gilbert J. Burckart, Gelareh Abulwerdi, Christin L. Daniels, Calib Choi, Rebecca Racz, Jean‐Pierre Valentin, Kristin Ardlie, Nicholas Tatonetti, Susan Laffan, Marjory Moreau, Will Redfern, Lang Li, James J. Hickman, Rajanikanth Madabushi, Bhagwat Prasad, Lynne Yao, Paul B. Watkins   +16 more
wiley   +1 more source

Beneficial Role of Natural Polyphenols Against Epilepsy: Greasing the Wheels of Pharmacotherapy Research for Epilepsy

Food Frontiers, Volume 7, Issue 6, November 2026.
ABSTRACT Epilepsy is the most disabling neurological disease that affects all economic classes, age groups, regions, and races. Although many antiseizure drugs are approved for epilepsy treatment, they fail to work in about 30%–40% of patients. Thus, there is a great need to identify better pharmacological agents to treat epilepsy.
Janakiraman Pillai Udaiyappan, Rengasamy Balakrishnan, Manivasagam Muthukumaran Tamilarasan, Subasri Pandian   +3 more
wiley   +1 more source

Effects of Serotonin Transporter Gene Variation on Impulsivity Mediated by Default Mode Network: A Family Study of Depression. [PDF]

Cereb Cortex, 2018
Cha J, Guffanti G, Gingrich J, Talati A, Wickramaratne P, Weissman M, Posner J.   +6 more
europepmc   +1 more source

Brain‐Derived Neurotrophic Factor (BDNF), Estrogen Receptors, and Mossy Cells

Hippocampus, Volume 36, Issue 6, November 2026.
ABSTRACT Dentate gyrus (DG) function depends on the neurotrophin brain‐derived neurotrophic factor (BDNF) which shows robust synthesis in the principal cells, the granule cells (GCs). However, BDNF protein is present in the inner molecular layer (IML), where most afferents to GCs are from hilar mossy cells (MCs). Therefore, we asked whether MCs express
Chiara Criscuolo, Monarchsinh Rathod, Fang Jie, Helen E. Scharfman   +3 more
wiley   +1 more source

Obsessive–Compulsive Disorder: Comorbidity, Biomarkers, Circuits, and Treatment Strategies

MedComm, Volume 7, Issue 11, November 2026.
OCD has a high comorbidity with other psychiatric conditions, among which anxiety is the most frequent one. The shared genetic biomarkers and common neural circuits underlying the co‐occurrence of OCD and anxiety pave a new path for understanding the pathogenic mechanism of OCD and suggest tailored and integrative treatment therapies for OCD from the ...
Xiao‐Yang Zhang, Zi‐Hao Li, Li‐Ping Shen, Bing‐Qing Kong, Qi‐Peng Zhang, Ya Ke, Juan Tu, Fei Wang, Wing‐Ho Yung, Jing‐Ning Zhu   +9 more
wiley   +1 more source

Neurodegenerative Diseases: Epidemiology, Risk Factors, Classification, Pathophysiology, Clinical Features, Diagnosis, and Therapeutic Strategies

MedComm, Volume 7, Issue 11, November 2026.
Neurodegenerative diseases share convergent risk architectures and pathological mechanisms, yet diverge in selective vulnerability, clinical presentation, and therapeutic responsiveness. This review integrates cross‐disease epidemiology, pathophysiology, diagnosis, and treatment, highlighting the transition from symptomatic care toward biomarker‐guided
Zimeng He, Jingjing Zeng, Guoqing Wang, Yuxin Li, Feng Zhang   +4 more
wiley   +1 more source

Atherosclerosis: From Pathogenesis to Therapeutic Interventions

MedComm, Volume 7, Issue 11, November 2026.
The diagram outlines the core mechanisms driving atherosclerosis, including endothelial dysfunction, inflammatory responses, phenotypic switching of smooth muscle cells, and the gut–vascular axis. It also presents the corresponding therapeutic approaches now under development, such as gene therapies, immunotherapies, and nanotechnology platforms ...
Enge Zhou, Chenxi Zhan, Yuting Li, Yi Zeng, Renfei Luo, Xin Ouyang, Shixing Liu, Renqiang Yang, Nianlong Yan, Long Jiang   +9 more
wiley   +1 more source