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Epigenetics of generalized internet use disorder including data on overuse of social media: a closer look at the SLC6A4, NR3C1 and OXT genes. [PDF]

BMC Psychiatry
Montag C, Kiefer M, Connemann BJ, Kammer T, Sanwald S.   +4 more
europepmc   +1 more source

The Serotonin Transporter Gene and Parkinson’s Disease

European Neurology, 2000
Dysfunction in the serotonin (5-hydroxytryptamine) system and reduced serotonin concentrations have been reported in patients with Parkinson’s disease (PD). Serotonin concentrations in neural tissue are controlled by a presynaptic serotonin transporter protein that is encoded by a single gene.
McCann, Sally J., McManus, Michael E., Johnson, Anthony G., Mellick, George D., Le Couteur, David G., Pond, Susan M.   +5 more
openaire   +6 more sources

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Organization of the Human Serotonin Transporter Gene

Journal of Neural Transmission, 1994
The gene encoding the human serotonin transporter (5-HTT) has been isolated and characterized. The human 5-HTT gene is composed of 14 exons spanning approximately 31 kb. The sequence of all exons including adjacent intronic sequences and a tandem repeat DNA polymorphism (VNTR) has been determined and deposited in the EMBL/GenBank data base with the ...
Klaus-Peter Lesch, B L Wolozin, D L Murphy   +2 more
exaly   +3 more sources

No Evidence for in Vivo Regulation of Midbrain Serotonin Transporter Availability by Serotonin Transporter Promoter Gene Polymorphism

Biological Psychiatry, 2001
A polymorphism in the serotonin transporter promoter gene region (5-HTTLPR) has been shown to influence the quantity of serotonin transporter expressed in human cell lines: the 5-HTTLPR short allele (s) has been associated with reduced 5-HTT expression when compared to cells carrying the 5-HTTLPR long allele (l).
Nicole Praschak-Rieder, Siegfried Kasper, Matthäus Willeit   +2 more
exaly   +3 more sources

Serotonin transporter gene polymorphisms: Effect on serotonin transporter availability in the brain of suicide attempters

Psychiatry Research: Neuroimaging, 2008
The efficacy of serotonin reuptake inhibitors in depression and anxiety disorders suggests the gene coding for the serotonin transporter (5-HTT), SLC6A4, as a candidate of importance for these conditions. Positive findings regarding associations between polymorphisms in SLC6A4 have been reported, indicating that these polymorphisms may influence ...
Jessica, Bah, Mats, Lindström, Lars, Westberg, Louise, Mannerås, Erik, Ryding, Susanne, Henningsson, Jonas, Melke, Ingmar, Rosén, Lil, Träskman-Bendz, Elias, Eriksson   +9 more
openaire   +3 more sources

Serotonin Transporter Gene

Psychosomatic Medicine, 2013
The serotonin transporter gene has been hypothesized to influence, possibly in interaction with environmental factors, the vulnerability for depression. So far, genetic studies have tested the association of the repeat polymorphism (5-HTTLPR) with depression and whether it is moderated by exposure to stressful events.
Anett Mueller, Turhan Canli
openaire   +6 more sources

Platelet Serotonin Transporters and the Transporter Gene in Control Subjects, Unipolar Patients and Bipolar Patients

Acta Psychiatrica Scandinavica, 2001
depression, platelet, serotonin transporter, serotonin transporter ...
Martin Balslev Jørgensen, Lis Hasholt, E Mellerup   +2 more
exaly   +2 more sources

Schizophrenia and the Serotonin Transporter Gene

Psychiatric Genetics, 1998
A case control study was conducted among cases with schizophrenia (DSM IV criteria) and screened adult controls from three cohorts. Bi-allelic polymorphisms in the promoter region of the serotonin transporter gene (5-HTT) were examined in conjunction with those of the serotonin 5-HT2a receptor (HTR2).
D, Rao, E G, Jönsson, S, Paus, R, Ganguli, M, Nöthen, V L, Nimgaonkar   +5 more
openaire   +2 more sources

The serotonin transporter gene as a QTL for ADHD

American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 2005
AbstractMolecular studies of attention deficit hyperactivity disorder (ADHD) have identified susceptibility genes for the categorically diagnosed disorder using operational diagnostic criteria. Here, we take a QTL approach to mapping genes for ADHD using a composite continuous index of ADHD behavior in a large epidemiological sample.
Craig, I, Sham, P, Curran, S, Purcell, S, Asherson, P   +4 more
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THE SEROTONIN TRANSPORTER GENE AND DEPRESSION

Depression and Anxiety, 2012
Psychiatric disorders such as depression are known to be under a degree of genetic influence, but the specific variants contributing to this heritability remain largely unknown.
Munafò, Marcus R
openaire   +2 more sources