Results 251 to 260 of about 2,926,392 (292)

The serotonin transporter gene and effectiveness of SSRIs

Expert Review of Neurotherapeutics, 2008
The definition of a genetic liability profile for specific antidepressant treatment will soon be available, offering considerable help in early detection of effective therapy in mood disorders. The search for genetic factors predisposing to drug response or side effects in mood disorders started only in the last few years.
SERRETTI, ALESSANDRO, Kato M.
openaire   +2 more sources

How the Serotonin Story Is Being Rewritten by New Gene-Based Discoveries Principally Related to SLC6A4, the Serotonin Transporter Gene, Which Functions to Influence All Cellular Serotonin Systems

Neuropharmacology, 2008
Discovered and crystallized over sixty years ago, serotonin's important functions in the brain and body were identified over the ensuing years by neurochemical, physiological and pharmacological investigations. This 2008 M.
Jens R Wendland, Pablo R Moya, Klaus-Peter Lesch   +2 more
exaly   +2 more sources

The serotonin transporter gene and peer-rated neuroticism

NeuroReport, 1997
Polymorphisms in the serotonin transporter gene (5HTT) have been reported to be associated with neuroticism (emotionality) and with depression. A recent report of an association between 5HTT and neuroticism involved unselected samples and self-report questionnaires. We attempted to extend these findings using a selected extremes design and peer ratings.
Ball, D, Hill, L, Freeman, B, Eley, TC, Strelau, J, Riemann, Rainer, Spinath, FM, Angleitner, Alois, Plomin, R   +8 more
openaire   +3 more sources

Serotonin transporter gene polymorphism and antidepressant response

NeuroReport, 2000
We examined allelic polymorphisms of the serotonin transporter (5-HTT) gene and antidepressant response to 6 weeks' treatment with the selective serotonin reuptake inhibitor (SSRI) drugs fluoxetine or paroxetine. We genotyped 120 patients and 252 normal controls, using polymerase chain reaction of genomic DNA with primers flanking the second intron and
D K, Kim, S W, Lim, S, Lee, S E, Sohn, S, Kim, C G, Hahn, B J, Carroll   +6 more
openaire   +2 more sources

Pleiotropy of the serotonin transporter gene for seasonality and neuroticism

Psychiatric Genetics, 2000
Pleiotropy refers to the ability of a single gene to influence multiple traits. A polymorphism in the regulatory region of the serotonin transporter gene (5-HTTLPR) has previously been found to be associated both with the personality trait of neuroticism and with seasonal changes in mood and behavior, or seasonality. Hypothesizing that the contribution
L, Sher, B D, Greenberg, D L, Murphy, N E, Rosenthal, L A, Sirota, D H, Hamer   +5 more
openaire   +2 more sources

Serotonin Transporter Gene Promoter Polymorphism and Alexithymia

Neuropsychobiology, 2012
<i>Background:</i> Recent neurobiological studies have reported that alexithymia may result from altered brain function related to emotional processing. Serotonin (5-hydroxytryptamine, 5-HT) has been shown to regulate central nervous system development associated with psychological processing.
Michiko, Kano, Tomoko, Mizuno, Yuko, Kawano, Masashi, Aoki, Motoyori, Kanazawa, Shin, Fukudo   +5 more
openaire   +2 more sources

Serotonin Transporter: Gene, Genetic Disorders, and Pharmacogenetics

Molecular Interventions, 2004
The highly evolutionarily conserved serotonin transporter (SERT) regulates the entire serotoninergic system and its receptors via modulation of extracellular fluid serotonin concentrations. Differences in SERT expression and function produced by three SERT genes and their variants show associations with multiple human disorders.
Dennis L, Murphy, Alicja, Lerner, Gary, Rudnick, Klaus-Peter, Lesch   +3 more
openaire   +2 more sources

Alternative Splicing of the Human Serotonin Transporter Gene

Journal of Neurochemistry, 1997
Abstract: To explore the structural basis for regulation of human serotonin transporter (hSERT) gene expression, we used primer extension and 5′ rapid amplification of cDNA ends (5′RACE) techniques to estimate levels of and identify 5′‐noncoding elements of hSERT mRNAs and genomic cloning to place these elements within the overall map of the hSERT gene.
C C, Bradley, R D, Blakely
openaire   +2 more sources

Serotonin transporter gene polymorphisms in alcohol dependence

Alcohol, 2000
The serotonin transporter (5-HTT) gene is a candidate gene in alcohol dependence because serotonin reuptake inhibitors (SRIs) can alleviate alcohol withdrawal. Studies of the 5-HTT gene in alcohol dependence have not resulted in a consensus. Recent studies have examined the transcriptionally active promoter polymorphism, a 44-bp deletion resulting in ...
M D, Thompson, N, Gonzalez, T, Nguyen, D E, Comings, S R, George, B F, O'Dowd   +5 more
openaire   +2 more sources

Role of the Serotonin Transporter Gene in Temperament and Character

Journal of Personality Disorders, 1999
The biosocial model postulates that personality is comprised of two broad domains: temperament, which is largely due to inherited variations in specific monoamine neurotransmitter systems; and character, which arises from socioculturally learned differences in values, goals, and self-concepts and is the strongest predictor of personality disorders. The
D H, Hamer, B D, Greenberg, S Z, Sabol, D L, Murphy   +3 more
openaire   +2 more sources