Results 21 to 30 of about 2,926,392 (292)

Brain hyperserotonemia causes autism-relevant social deficits in mice

Molecular Autism, 2018
Background Hyperserotonemia in the brain is suspected to be an endophenotype of autism spectrum disorder (ASD). Reducing serotonin levels in the brain through modulation of serotonin transporter function may improve ASD symptoms.
Miho Tanaka, Atsushi Sato, Shinya Kasai, Yoko Hagino, Hiroko Kotajima-Murakami, Hirofumi Kashii, Yukio Takamatsu, Yasumasa Nishito, Masumi Inagaki, Masashi Mizuguchi, F. Scott Hall, George R. Uhl, Dennis Murphy, Ichiro Sora, Kazutaka Ikeda   +14 more
doaj   +1 more source

Moderation of antidepressant response by the serotonin transporter gene [PDF]

British Journal of Psychiatry, 2009
BackgroundThere have been conflicting reports on whether the length polymorphism in the promoter of the serotonin transporter gene (5-HTTLPR) moderates the antidepressant effects of selective serotonin reuptake inhibitors (SSRIs). We hypothesised that the pharmacogenetic effect of 5-HTTLPR is modulated by gender, age and other variants in the serotonin
Huezo-Diaz, Patricia, Uher, Rudolf, Smith, Robert Peter, Rietschel, Marcella, Henigsberg, Neven, Marusic, Andrej, Mors, Ole, Maier, W., Hauser, Joanna Wiktoria, Souery, Daniel, Placentino, Anna, Zobel, Astrid, Larsen, Erik Roj, Czerski, Piotr M.Piotr, Gupta, Bhanu, Hoda, Farzana, Perroud, Nader, Farmer, Anne, Craig, Ian, Aitchison, Katherine, McGuffin, Peter   +20 more
openaire   +5 more sources

Serotonin and Dopamine Gene Variation and Theory of Mind Decoding Accuracy in Major Depression: A Preliminary Investigation.

PLoS ONE, 2016
Theory of mind-the ability to decode and reason about others' mental states-is a universal human skill and forms the basis of social cognition. Theory of mind accuracy is impaired in clinical conditions evidencing social impairment, including major ...
Arielle Y Zahavi, Mark A Sabbagh, Dustin Washburn, Raegan Mazurka, R Michael Bagby, John Strauss, James L Kennedy, Arun Ravindran, Kate L Harkness   +8 more
doaj   +1 more source

Serotonin gene polymorphisms and bipolar I disorder: Focus on the serotonin transporter

Annals of Medicine, 2005
The pathogenesis of bipolar disorder may involve, at least in part, aberrations in serotonergic neurotransmission. Hence, serotonergic genes are attractive targets for association studies of bipolar disorder. We have reviewed the literature in this field. It is difficult to synthesize results as only one polymorphism per gene was typically investigated
MANSOUR, H., TALKOWSKI, M. E., WOOD, J., PLESS, L., BAMNE, M., CHOWDARI, K., ALLEN, M., BOWDEN, C. L., CALABRESE, J., EL-MALLAKH, R., FAGIOLINI, A., FARAONE, S. V., FOSSEY, M., FRIEDMAN, E., GYULAI, L., HAUSER, P., KETTER, T., LOFTIS, J., MARANGELL, L., MIKLOWITZ, D., NIERENBERG, A., PATEL, G., SACHS, G., SKLAR, P., SMOLLER, J., THASE, M., FRANK, E., KUPFER, D., NIMGAONKAR, V.   +28 more
openaire   +3 more sources

Genetic and pharmacological manipulations of the serotonergic system in early life: Neurodevelopmental underpinnings of autism-related behaviour

Frontiers in Cellular Neuroscience, 2013
Serotonin, in its function as neurotransmitter, is well-known for its role in depression, autism and other neuropsychiatric disorders, however less known as a neurodevelopmental factor.
Karsten eKinast, Deborah ePeeters, Sharon Margriet Kolk, Dirk eSchubert, Judith Regina Homberg   +4 more
doaj   +1 more source

Functional reorganization of monoamine transport systems during villous trophoblast differentiation: evidence of distinct differences between primary human trophoblasts and BeWo cells

Reproductive Biology and Endocrinology, 2022
Background Three primary monoamines—serotonin, norepinephrine, and dopamine—play major roles in the placenta-fetal brain axis. Analogously to the brain, the placenta has transport mechanisms that actively take up these monoamines into trophoblast cells ...
Veronika Vachalova, Rona Karahoda, Martina Ottaviani, Kasin Yadunandam Anandam, Cilia Abad, Christiane Albrecht, Frantisek Staud   +6 more
doaj   +1 more source

Significance of serotonin transporter gene polymorphism in migraine

Journal of the Neurological Sciences, 2001
To elucidate significance of the serotonin transporter gene (STG) polymorphism in migraine, and to address the polymorphic patterns of STG, both in the migraineurs and healthy people in this country.A PCR study of STG in 52 migraineurs and 80 healthy controls.Using the PCR technique, STG polymorphism was studied in the DNA obtained from leukocytes of ...
Erdal, Mehmet Emin, Barlas, İbrahim Ömer, YILMAZ, MUSTAFA, HERKEN, HASAN, ÇATALOLUK, OSMAN, Bayazıt, Yıldırım A.   +5 more
openaire   +3 more sources

Serotonin transporter gene-linked polymorphism affects detection of facial expressions. [PDF]

PLoS ONE, 2013
Previous studies have demonstrated that the serotonin transporter gene-linked polymorphic region (5-HTTLPR) affects the recognition of facial expressions and attention to them.
Ai Koizumi, Norimichi Kitagawa, Hirohito M Kondo, Miho S Kitamura, Takao Sato, Makio Kashino   +5 more
doaj   +1 more source

5-hydroxytryptamine (5-HT) cellular sequestration during chronic exposure delays 5-HT₃ receptor resensitization due to Its subsequent release [PDF]

, 2014
The serotonergic synapse is dynamically regulated by serotonin (5-hydroxytryptamine (5-HT)) with elevated levels leading to the down-regulation of the serotonin transporter and a variety of 5-HT receptors, including the 5-HT type-3 (5-HT3) receptors.
Moffat, Christopher, Bollan, Karen A., Connolly, Christopher N., Samson, Andrew J., Alexander, Amy, Hothersall, J. Daniel   +5 more
core   +1 more source

Antidepressant discontinuation in treatment resistant depression

Contemporary Clinical Trials Communications, 2019
Treatment-resistant depression (TRD) is a growing problem in psychiatric practice with some 15–20% of depressed patients becoming chronically depressed and perhaps as many as 40% in tertiary settings.
Ziad A. Ali, Sharon Nuss, Rif S. El-Mallakh   +2 more
doaj   +1 more source