Results 41 to 50 of about 2,926,392 (292)

Human psychophysiological responses to visceral and somatic pain – the development of integrated, reproducible human pain phenotypes [PDF]

, 2011
PhDBackground Pain is the ubiquitous human experience, yet displays considerable inter- and intraindividual variability in health and disease. Many factors have been proposed to account for these differences.
Farmer, Adam Donald
core   +2 more sources

Association between serotonin transporter gene polymorphism and obsessive–compulsive disorder in the Egyptian population

Middle East Current Psychiatry
Background Obsessive–compulsive disorder (OCD) is a debilitating disorder that has multifactorial etiology including genetic, neurobiological, cognitive, and environmental influences.
Sara Mehrez, Mustafa Ahmed Neamatallah, Zeinab Gomaa, Abdel-Hady El-Gilany, Mohammed Shahda, Hiam F Elsaied   +5 more
doaj   +1 more source

Serotonin control of thermotaxis memory behavior in nematode Caenorhabditis elegans. [PDF]

PLoS ONE, 2013
Caenorhabditis elegans is as an ideal model system for the study of mechanisms underlying learning and memory. In the present study, we employed C. elegans assay system of thermotaxis memory to investigate the possible role of serotonin neurotransmitter ...
Yinxia Li, Yunli Zhao, Xu Huang, Xingfeng Lin, Yuling Guo, Daoyong Wang, Chaojun Li, Dayong Wang   +7 more
doaj   +1 more source

Gonadotropin‐Inhibitory Hormone (GnIH) and Its Receptor GPR147 Mediates Acute Stress‐Induced Activation of the Locus Coeruleus‐SAM Axis

Advanced Science, EarlyView.
ABSTRACT Gonadotropin‐inhibitory hormone (GnIH, also known as RFamide‐related peptide‐3, RFRP‐3) is a hypothalamic neuropeptide that regulates vertebrate reproduction via its receptor GPR147. Although GnIH is known to mediate stress‐induced reproductive suppression, its role in broader stress responses remains unclear.
Jiani Zhang, Hongyu Zhu, Wenqi Wang, Bingqian Shen, Yuanyuan Xin, Xingxing Song, Xuanyi Lu, Lixuan Li, Siting Chen, Xiaochen Zhang, Jialing Zeng, Haodong Zheng, Jianlong Lao, Ke Peng, Yixian Wei, Jiaming Zheng, Chuanhuo Hu, Xiaoye Wang, Xun Li   +18 more
wiley   +1 more source

Affective neural responses modulated by serotonin transporter genotype in clinical anxiety and depression. [PDF]

PLoS ONE, 2015
Serotonin transporter gene variants are known to interact with stressful life experiences to increase chances of developing affective symptoms, and these same variants have been shown to influence amygdala reactivity to affective stimuli in non ...
Desmond J Oathes, Lori M Hilt, Jack B Nitschke   +2 more
doaj   +1 more source

Charting Endocrine Progenitors Across Species and Organs

Advanced Science, EarlyView.
Endocrine progenitors give rise to the hormone‐producing cells of the pancreas and intestine. Using single‐cell multiomics and proteomics, this study compares these progenitors across species, systems, and organs, mapping the conserved and species‐specific gene regulatory networks that guide their formation.
Changying Jing, Michael Sterr, Özüm Sehnaz Caliskan, Lama Saber, Nicole Katarina Rogers, Samuel Ogden, Kei Kozawa, Christos Karampelias, Jessica Jaki, Aimée Bastidas‐Ponce, Falk Janos Farkas, Oliver Czarnecki, Osvaldo Rodrigues Pereira, Perla Cota, Valerie Vandenbempt, Diego Balboa, Anika Böttcher, Natalie Krahmer, Mohammad Lotfollahi, Julie B. Sneddon, Heiko Lickert, Mostafa Bakhti   +21 more
wiley   +1 more source

Serotonin Transporter Gene Polymorphisms and Bone Mineral Density in North Indian Postmenopausal Women

Türk Osteoporoz Dergisi
Objective: Osteoporosis is a serious metabolic bone disease worldwide, with genetic factors contributing significantly. We investigated the 5-HTT variable number tandem repeats (5HTTVNTR) & serotonin transporter gene 5-hydroxy tryptamine transporter ...
Priya Dixit, Israr Ahmad, Shah Waliullah, Tabrez Jafar   +3 more
doaj   +1 more source

Neonatal Tactile Stimulation Alters Behaviors in Heterozygous Serotonin Transporter Male Rats: Role of the Amygdala

Frontiers in Behavioral Neuroscience, 2020
The serotonin transporter (SERT) gene, especially the short allele of the human serotonin transporter linked polymorphic region (5-HTTLPR), has been associated with the development of stress-related neuropsychiatric disorders.
Karine Roversi, Carolina Buizza, Paola Brivio, Francesca Calabrese, Michel M. M. Verheij, Caren T. D. Antoniazzi, Marilise E. Burger, Marco A. Riva, Judith R. Homberg   +8 more
doaj   +1 more source

Disrupted TFEB/GDNF–cAMP/ATP Coupling Underlies Astrocytic Dysfunction and Depression in LRRK2 G2019S Parkinson's Mice

Advanced Science, EarlyView.
ABSTRACT The LRRK2 G2019S mutation, a Parkinson's disease–linked variant, has been associated with depression‐like phenotypes, but mechanisms remain unclear. We chart age‐dependent behavioral changes and astrocyte reactivity in G2019S mice and define a pathway connecting LRRK2 to TFEB/GDNF signaling, cellular energetics, and inflammation.
Longping Yao, Maryam Hatami, Sumeyye Koc, Qing Jiang, Thomas Skutella, Yuanfeng Zhang   +5 more
wiley   +1 more source

Genes, Economics and Happiness [PDF]

A major finding from research into the sources of subjective well-being is that individuals exhibit a "baseline" level of happiness. We explore the influence of genetic variation by employing a twin design and genetic association study.
Jan-Emmanuel De Neve, Nicholas A. Christakis, Bruno S. Frey, James H. Fowler   +3 more
core   +2 more sources